Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.14.99.3 (heme oxygenase)
 4,196 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Heme oxygenase (decyclizing) 12.9
HO-2 11.9
SNF1-like kinase 2 11.9
GLYCOLATE OXIDASE 1 11.9
a disintegrin and metalloprotease domain 33 11.9
5-aminolevulinate synthase 1 11.9
heme oxygenase-1 11.7
lipocalin-interacting membrane receptor 11.3
Sterol O-acyltransferase 1 11.3
biliverdin reductase 11.2
HMOX1 protein 11.1
HO-1 11.0
ST3GalV 10.9
glutathione S-transferase alpha 1 10.9
Signal-regulatory protein alpha 10.9
heme oxygenase (decycling) 1 10.9
HMOX2 10.9
COTE1 10.9
glutamate-cysteine ligase modifier subunit 10.7
collagen, type IV, alpha 1 10.6
4EBP2 10.6
HMX1 10.6
ATP6V1D 10.6
BTBD2 10.3
IFP1 10.3
MT1L 10.3
delta-aminolevulinate synthase 10.1
HMOX1 10.0
ALAS-E 9.9
interleukin 2 receptor gamma chain 9.9
neurofilament triplet L protein 9.9
HO2 9.8
HO3 9.7
mitogen-activated protein kinase kinase kinase 7 9.7
sestrin 1 9.7
TMOD3 9.7
BRLZ 9.6
101F6 9.6
RAI14 9.6
PAG608 9.6
glutamate-cysteine ligase 9.5
MRS3/4 9.5
Orosomucoid 1 9.4
HOX1 9.4
oxidation resistance 1 9.4
SOUL 9.4
SDR2 9.4
surfactant protein A1 9.4
glutathione peroxidase 6 9.4
nuclear factor (erythroid-derived 2)-like 2 9.4
ALAS 9.2
v-myc myelocytomatosis viral oncogene homolog 9.2
selectin P 9.2
fructose-bisphosphate aldolase C 9.2
P53-binding protein 9.2
cell division cycle 25B 9.2
KEAP1 protein 9.1
lysosomal protein transmembrane 4 beta 9.1
PCBP3 9.1
PAOh1 9.1
ALAS1 9.0
NF-E2-related factor 2 9.0
PCBP4 9.0
PTP36 8.9
FLVCR 8.9
phosphoenolpyruvate carboxykinase 2 8.9
Hemopexin 8.9
glutathione S-transferase A1 8.8
BTB and CNC homology 1 8.8
PSTK 8.7
RDH8 8.7
alpha-CP2 8.7
PIPK 8.7
SLC6A13 8.7
NFE2L2 8.7
Kelch-like ECH-associated protein 1 8.7
HEMO 8.7
GCLM 8.7
NQO1 8.7
glutathione S-transferase A2 8.6
more...
Disease
iron loading anemia 11.9
Centrilobular hepatic necrosis 10.9
Acute glaucoma 9.2
Hepatoerythropoietic porphyria 9.2
PORC 8.6
EA3 8.6
Neonatal hyperbilirubinemia 8.5
Chronic HIV infection 8.1
hemoglobinemia 7.6
crystal arthropathy 7.5
neonatal jaundice 7.4
hepatic porphyria 7.3
Toxicosis 7.0
hyperbilirubinemia 7.0
craniofrontonasal syndrome 7.0
X-linked sideroblastic anemia 7.0
cholestatic cirrhosis 6.8
HFE2 6.8
nodular malignant melanoma 6.8
kidney hypertrophy 6.8
placental disorders 6.7
ARP1 6.7
kernicterus 6.5
Placental insufficiency 6.5
Pulmonary veno-occlusive disease 6.4
Oxygen toxicity 6.4
DMT1 6.3
disorders of iron metabolism 6.3
Cardiovascular morbidity 6.2
vascular dilation 6.1
porphyria 6.1
myelinopathy 5.9
Chronic migraine 5.9
PLAT 5.9
hypochromic anemia 5.9
Strongyloides stercoralis infection 5.8
POH 5.8
CSE 5.6
hemoglobinuria 5.6
Carotid body 5.6
Carotid body 5.6
Carotid body 5.6
Estrogen deficiency 5.5
Hepatopulmonary syndrome 5.5
GSH 5.4
Diabetic neuropathy 5.4
CAPA 5.3
endotoxic shock 5.2
Krabbe disease 5.2
vitamin C deficiency 5.2
HSP 5.2
acute intermittent porphyria 5.1
NAME 5.1
Dubin-Johnson syndrome 5.1
vitamin B6 deficiency 5.1
Retinal degeneration 5.0
Crigler-Najjar syndrome 5.0
FIP 5.0
Hallervorden-Spatz disease 5.0
renal ischemia 4.9
Plasmodium falciparum infection 4.9
Enzyme inhibition 4.9
iron overload 4.9
pregnancy disorder 4.9
refractory cancer 4.8
diabetic cardiomyopathy 4.8
erythropoietic protoporphyria 4.8
hemangiomatosis 4.8
amelanotic melanoma 4.7
AOS 4.7
testicular dysfunction 4.7
EGC 4.7
tyrosinemia 4.6
Rocky Mountain spotted fever 4.6
Gilbert 4.6
Intestinal ischemia 4.6
Brain stem 4.6
genetic hypertension 4.6
GALT 4.5
pneumonic plague 4.5
more...
Symptom
Peripheral neuropathic pain 7.9
hyperoxia 5.2
lassitude 4.7
prostration 4.4
tenesmus 4.0
skin damage 3.9
forgetfulness 3.5
bradykinesia 3.3
dry skin 2.9
memory loss 2.7
acute pain 2.5
hypercapnia 2.5
Neuropathic pain 2.4
acute stress 2.3
functional recovery 2.2
hypocapnia 2.2
sneezing 2.0
hypothermia 1.6
erythema 1.5
hepatomegaly 1.4
HSA 1.3
polyuria 1.3
starvation 1.3
respiratory distress 1.2
splenomegaly 1.2
seizures 0.8
hepatosplenomegaly 0.8
exhaustion 0.7
anorexia 0.7
tremor 0.7
syncope 0.7
shortness of breath 0.5
anesthesia 0.5
collapse 0.4
pain 0.4
spasticity 0.2
angina 0.1
acidity 0.0
vomiting -0.1
weakness -0.3
low back pain -0.4
discomfort -0.6
nausea -0.6
discomfort -0.7
overweight -0.8
analgesia -0.9
abdominal pain -1.0
ataxia -1.1
diarrhea -1.3
fatigue -1.8
Drug
Asperlin 11.3
P-Nitrophenol 10.9
Mesoheme 10.6
Neotrofin 10.3
Heme 9.7
Stannous chloride 8.5
Pentaerythritol tetranitrate 8.4
Motexafin gadolinium 8.2
MCZ 7.8
Glutethimide 7.8
Bucillamine 7.6
Gly-Tyr-Gly 7.5
Mevastatin 7.5
Amlexanox 7.4
MCZ 7.4
CoCl2 7.4
CoCl2 7.4
Solon 7.2
Aluminum chloride 7.1
Levitra 7.0
ALA 7.0
Butaprost 6.9
Levitra 6.7
Gold sodium thiomalate 6.6
Vardenafil 6.4
Deuterium oxide 6.4
Glybenclamide 6.3
Safflower 5.9
Zevalin 5.9
Axitinib 5.8
Vinpocetine 5.7
ROX 5.7
Arsenic trioxide 5.6
Pentostam 5.5
3-Methyladenine 5.5
Auranofin 5.5
Agomelatine 5.4
Fenoldopam 5.3
Camphor 5.3
Camphor 5.3
Tranilast 5.2
Cilostazol 5.2
NOV 5.2
PE2 5.1
Glucantime 5.0
Ginger 5.0
Desferal 4.9
metformin hydrochloride 4.9
Photofrin II 4.9
KCL 4.8
Guanethidine 4.8
Desferal 4.8
Photofrin 4.6
Duloxetine 4.6
Kainic acid 4.6
Sodium nitroprusside 4.5
ROS 4.5
Flavin 4.5
DEL 4.5
HPMPC 4.4
Limonene 4.4
Nitric Oxide 4.4
Tao 4.3
CIA 4.3
Cimetidine 4.2
Pravastatin 4.2
Simvastatin 4.2
Cimetidine 4.2
CPR 4.2
ZnCl2 4.1
ZnCl2 4.1
Epigallocatechin 4.1
Rosuvastatin 4.1
FAD 4.0
Viagra 4.0
Glutathione 4.0
Glutamic acid 3.9
Angiotensin II 3.7
Viagra 3.7
ascorbate 3.6
more...
Enzyme
heme oxygenase 12.9
biliverdin reductase 11.4
phycocyanobilin:ferredoxin oxidoreductase 11.1
PebA 10.3
PebB 10.3
ALA synthase 10.0
HY2 8.6
porphobilinogenase 8.6
ferrochelatase 8.3
gamma-glutamylcysteine synthetase 8.2
glycine N-acyltransferase 7.9
choline monooxygenase 7.8
NQO1 7.5
ECH 7.5
delta-aminolevulinic acid dehydratase 7.3
coproporphyrinogen oxidase 7.2
tyrosylprotein sulfotransferase 7.1
uroporphyrinogen decarboxylase 7.0
ferredoxin reductase 6.9
guanylate cyclase 6.8
porphobilinogen deaminase 6.7
carboxypeptidase S 6.7
TSO 6.7
squalene epoxidase 6.7
threonine aldolase 6.7
NADPH:quinone oxidoreductase 6.6
cystathionine gamma-lyase 6.4
nicotinamide N-methyltransferase 6.3
glutathione synthetase 6.3
adrenodoxin reductase 6.3
glutamyl-tRNA reductase 6.2
Mg-chelatase 6.2
protochlorophyllide oxidoreductase 6.2
glutaminyl cyclase 6.2
polyphosphatase 6.1
myrosinase 6.1
methionine sulfoxide reductase 6.0
demethylase 6.0
cysteine synthase 5.9
sulfiredoxin 5.9
NADH-cytochrome b5 reductase 5.8
CPR 5.8
NO synthase 5.8
glycogenin 5.7
glutathione peroxidase 5.7
aryl hydrocarbon hydroxylase 5.7
AMP-activated kinase 5.6
protoporphyrinogen oxidase 5.6
betaine-homocysteine methyltransferase 5.6
thioredoxin reductase 5.5
tryptophan 2,3-dioxygenase 5.5
superoxide dismutase 5.5
UDP-glucuronosyltransferase 5.4
glutathione reductase 5.4
coproporphyrinogen III oxidase 5.4
cystathionine gamma-synthase 5.4
NOS 5.4
NADPH oxidase 5.4
CLK1 5.4
soluble epoxide hydrolase 5.4
kynurenine 3-monooxygenase 5.3
cystathionine beta-synthase 5.3
tyrosine decarboxylase 5.3
microsomal epoxide hydrolase 5.3
transaldolase 5.2
NADPH oxidase 5.2
peroxiredoxin 5.1
cysteine dioxygenase 5.1
catalase 5.1
ancrod 5.1
methylthioadenosine phosphorylase 5.0
3-mercaptopyruvate sulfurtransferase 5.0
indoleamine 2,3-dioxygenase 5.0
PRPP synthetase 5.0
DMT 5.0
pantothenate kinase 4.9
PKG 4.9
GalT 4.7
paraoxonase 4.7
S-adenosylmethionine decarboxylase 4.7
more...
Compound
C9H11N2O2 12.9
4,4-diphenyl-2-butanone 12.9
4,4-diphenyl-2-butanone 12.9
Asperlin 11.3
Zinc protoporphyrin 11.0
Aureusidin 10.9
Ethyl ferulate 10.6
C8H16O2 10.6
C8H16O2 10.6
Biliverdin 10.5
C15H20O3 10.3
C7H9N3O3 10.1
Mesoporphyrin IX 10.1
LNO2 10.0
Succinylacetone 9.8
Heme 9.6
Protoporphyrin IX 9.5
Indole-3-acetamide 9.4
L-Lysine monohydrochloride 9.4
Hemin 9.4
Hemin 9.4
Hemin 9.4
Hemin 9.4
Hemin 9.4
Caprin 9.3
Sulfuretin 9.2
Phorone 9.1
Phorone 9.1
4-Methylcatechol 9.1
Mesoporphyrin 8.9
hydroxymethylbilane 8.8
Spinasterol 8.6
Cobaltous chloride 8.6
Terconazole 8.6
Taraxasterol 8.6
Tin 8.5
Tryptanthrin 8.5
Terrein 8.4
Taurolithocholate 8.4
Saikosaponin A 8.4
delta-aminolevulinic acid 8.3
Aurothioglucose 8.3
Butein 8.2
Glutethimide 8.1
Ginkgolide A 8.0
N,N'-dimethylthiourea 8.0
LNFP III 8.0
Eriodictyol 7.9
Xanomeline 7.9
Bilirubin 7.9
Neohesperidin 7.9
Ophiobolin A 7.8
Bilobalide 7.7
PGJ2 7.6
Buthionine sulfoximine 7.6
tin 7.5
MK 571 7.5
Selenocystine 7.5
3'-UMP 7.5
Orientin 7.4
Protochlorophyllide 7.4
Aloin 7.3
1-tetradecene 7.3
Phenylhydrazine 7.2
Oxyresveratrol 7.2
Ginkgolide B 7.2
CBrCl3 7.2
Ziram 7.1
BMN 7.1
Alantolactone 7.1
DDMS 7.1
bromobenzene 7.0
Palmatine 7.0
Gadolinium chloride 7.0
Pelargonidin 7.0
Aloin 6.9
Galangin 6.9
Sinapic acid 6.9
Fisetin 6.9
beta-Naphthoflavone 6.9
more...