EC:1.14.99.3 - FACTA Search

Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Target Concepts:

Query: EC:1.14.99.3 (heme oxygenase)
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Human Gene/Protein
Heme oxygenase (decyclizing)	12.9
HO-2	11.9
5-aminolevulinate synthase 1	11.9
GLYCOLATE OXIDASE 1	11.9
a disintegrin and metalloprotease domain 33	11.9
SNF1-like kinase 2	11.9
heme oxygenase-1	11.7
lipocalin-interacting membrane receptor	11.3
Sterol O-acyltransferase 1	11.3
biliverdin reductase	11.2
HMOX1 protein	11.1
HO-1	11.0
heme oxygenase (decycling) 1	10.9
glutathione S-transferase alpha 1	10.9
HMOX2	10.9
ST3GalV	10.9
COTE1	10.9
Signal-regulatory protein alpha	10.9
glutamate-cysteine ligase modifier subunit	10.7
collagen, type IV, alpha 1	10.6
4EBP2	10.6
HMX1	10.6
ATP6V1D	10.6
BTBD2	10.3
IFP1	10.3
MT1L	10.3
delta-aminolevulinate synthase	10.1
HMOX1	10.0
ALAS-E	9.9
neurofilament triplet L protein	9.9
interleukin 2 receptor gamma chain	9.9
HO2	9.8
sestrin 1	9.7
HO3	9.7
TMOD3	9.7
mitogen-activated protein kinase kinase kinase 7	9.7
BRLZ	9.6
PAG608	9.6
RAI14	9.6
101F6	9.6

Disease
iron loading anemia	11.9
Centrilobular hepatic necrosis	10.9
Acute glaucoma	9.2
Hepatoerythropoietic porphyria	9.2
PORC	8.6
EA3	8.6
Neonatal hyperbilirubinemia	8.5
Chronic HIV infection	8.1
hemoglobinemia	7.6
crystal arthropathy	7.5
neonatal jaundice	7.4
hepatic porphyria	7.3
Toxicosis	7.0
hyperbilirubinemia	7.0
craniofrontonasal syndrome	7.0
X-linked sideroblastic anemia	7.0
cholestatic cirrhosis	6.8
nodular malignant melanoma	6.8
HFE2	6.8
kidney hypertrophy	6.8
placental disorders	6.7
ARP1	6.7
kernicterus	6.5
Placental insufficiency	6.5
Pulmonary veno-occlusive disease	6.4
Oxygen toxicity	6.4
DMT1	6.3
disorders of iron metabolism	6.3
Cardiovascular morbidity	6.2
vascular dilation	6.1
porphyria	6.1
myelinopathy	5.9
Chronic migraine	5.9
PLAT	5.9
hypochromic anemia	5.9
Strongyloides stercoralis infection	5.8
POH	5.8
CSE	5.6
hemoglobinuria	5.6
Carotid body	5.6

Symptom
Peripheral neuropathic pain	7.9
hyperoxia	5.2
lassitude	4.7
prostration	4.4
tenesmus	4.0
skin damage	3.9
forgetfulness	3.5
bradykinesia	3.3
dry skin	2.9
memory loss	2.7
acute pain	2.5
hypercapnia	2.5
Neuropathic pain	2.4
acute stress	2.3
functional recovery	2.2
hypocapnia	2.2
sneezing	2.0
hypothermia	1.6
erythema	1.5
hepatomegaly	1.4
HSA	1.3
polyuria	1.3
starvation	1.3
respiratory distress	1.2
splenomegaly	1.2
seizures	0.8
hepatosplenomegaly	0.8
exhaustion	0.7
anorexia	0.7
tremor	0.7
syncope	0.7
shortness of breath	0.5
anesthesia	0.5
collapse	0.4
pain	0.4
spasticity	0.2
angina	0.1
acidity	0.0
vomiting	-0.1
weakness	-0.3

Drug
Asperlin	11.3
P-Nitrophenol	10.9
Mesoheme	10.6
Neotrofin	10.3
Heme	9.7
Stannous chloride	8.5
Pentaerythritol tetranitrate	8.4
Motexafin gadolinium	8.2
MCZ	7.8
Glutethimide	7.8
Bucillamine	7.6
Gly-Tyr-Gly	7.5
Mevastatin	7.5
Amlexanox	7.4
MCZ	7.4
CoCl2	7.4
CoCl2	7.4
Solon	7.2
Aluminum chloride	7.1
Levitra	7.0
ALA	7.0
Butaprost	6.9
Levitra	6.7
Gold sodium thiomalate	6.6
Vardenafil	6.4
Deuterium oxide	6.4
Glybenclamide	6.3
Safflower	5.9
Zevalin	5.9
Axitinib	5.8
Vinpocetine	5.7
ROX	5.7
Arsenic trioxide	5.6
Pentostam	5.5
3-Methyladenine	5.5
Auranofin	5.5
Agomelatine	5.4
Fenoldopam	5.3
Camphor	5.3
Camphor	5.3

Enzyme
heme oxygenase	12.9
biliverdin reductase	11.4
phycocyanobilin:ferredoxin oxidoreductase	11.1
PebB	10.3
PebA	10.3
ALA synthase	10.0
HY2	8.6
porphobilinogenase	8.6
ferrochelatase	8.3
gamma-glutamylcysteine synthetase	8.2
glycine N-acyltransferase	7.9
choline monooxygenase	7.8
NQO1	7.5
ECH	7.5
delta-aminolevulinic acid dehydratase	7.3
coproporphyrinogen oxidase	7.2
tyrosylprotein sulfotransferase	7.1
uroporphyrinogen decarboxylase	7.0
ferredoxin reductase	6.9
guanylate cyclase	6.8
porphobilinogen deaminase	6.7
carboxypeptidase S	6.7
TSO	6.7
threonine aldolase	6.7
squalene epoxidase	6.7
NADPH:quinone oxidoreductase	6.6
cystathionine gamma-lyase	6.4
nicotinamide N-methyltransferase	6.3
glutathione synthetase	6.3
adrenodoxin reductase	6.3
glutamyl-tRNA reductase	6.2
Mg-chelatase	6.2
protochlorophyllide oxidoreductase	6.2
glutaminyl cyclase	6.2
polyphosphatase	6.1
myrosinase	6.1
methionine sulfoxide reductase	6.0
demethylase	6.0
cysteine synthase	5.9
sulfiredoxin	5.9