Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.14.99.3 (
heme oxygenase
)
4,196
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
heme oxygenase-1
3778
HO-1
1052
erythroid
356
Mol
325
superoxide dismutase
304
Nrf2
275
HO-2
271
Sep
264
nitric oxide synthase
258
microsomal
253
catalase
240
inducible nitric oxide synthase
223
GSH
213
lipopolysaccharide
201
tumor necrosis factor
191
cytochrome P-450
180
hemoglobin
171
TNF
160
cytokine
155
glutathione peroxidase
147
more...
Disease
GSH
213
ischemia
189
cancer
146
hypertension
116
diabetes
108
tumor
91
Alzheimer's disease
85
atherosclerosis
79
stroke
75
hyperbilirubinemia
64
NAME
60
sepsis
57
sepsis
57
hepatocellular carcinoma
56
depression
40
obesity
38
cardiovascular disease
38
carcinogenesis
36
hyperglycemia
36
Parkinson's disease
34
more...
Symptom
pain
45
hyperoxia
25
anesthesia
21
seizures
19
starvation
8
functional recovery
8
hypothermia
7
respiratory distress
6
hypercapnia
6
erythema
5
collapse
5
vomiting
4
tremor
4
weakness
4
exhaustion
3
diarrhea
3
splenomegaly
3
acute stress
3
skin damage
3
acute pain
3
more...
Drug
Heme
332
ROS
59
ALA
47
ascorbate
38
CoCl2
27
CoCl2
27
NADH
25
vitamin E
19
IFN-gamma
16
Dermatol
13
lysine
13
FAD
12
Cardiovasc
12
Glutathione
11
MAP
10
CSF
9
Angiotensin II
9
Arsenic trioxide
8
ICI
7
Nitric Oxide
7
more...
Enzyme
heme oxygenase
4196
superoxide dismutase
340
catalase
247
mitogen-activated protein kinase
205
NQO1
152
glutathione peroxidase
150
ALA synthase
138
guanylate cyclase
126
NO synthase
116
biliverdin reductase
101
caspase-3
101
protein kinase
93
peroxidase
90
glutathione S-transferase
69
alanine aminotransferase
64
gamma-glutamylcysteine synthetase
57
NADPH oxidase
56
glutathione reductase
54
luciferase
54
lactate dehydrogenase
54
more...
Compound
CO2
831
oxygen
792
iron
612
nitric oxide
456
Heme
361
zinc
305
Dec
293
tin
283
DNA
239
GSH
218
GSH
218
hydrogen
181
sodium
174
water
172
TNF
160
cobalt
148
cGMP
145
arginine
137
NADPH
134
NADPH
133
more...