Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.14.99.3 (heme oxygenase)
 4,196 document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
heme oxygenase-1 3778
HO-1 1052
erythroid 356
Mol 325
superoxide dismutase 304
Nrf2 275
HO-2 271
Sep 264
nitric oxide synthase 258
microsomal 253
catalase 240
inducible nitric oxide synthase 223
GSH 213
lipopolysaccharide 201
tumor necrosis factor 191
cytochrome P-450 180
hemoglobin 171
TNF 160
cytokine 155
glutathione peroxidase 147
ferritin 138
NADPH 133
caspase-3 127
IL-6 122
NQO1 120
cytochrome P450 113
p38 112
biliverdin reductase 109
guanylate cyclase 100
NAD 96
insulin 84
reductase 77
HO2 75
cyclooxygenase 73
quinone oxidoreductase 70
DT-diaphorase 69
heat shock protein 69
cyclooxygenase-2 68
LPS 64
antioxidant enzyme 63
cytochrome 61
HSP70 61
ATP 60
ROS 59
myeloperoxidase 59
Bcl-2 59
MAPK 59
endoplasmic reticulum 59
p65 58
IL-10 56
COX-2 55
soluble guanylyl cyclase 53
glutathione S-transferase 53
lactate dehydrogenase 52
myoglobin 51
HMOX1 50
glutathione reductase 50
vascular endothelial growth factor 49
P450 49
metallothionein 48
NF-E2-related factor 2 48
SOD 48
mitogen-activated protein 46
interleukin-6 45
glutamate-cysteine ligase 45
oxidoreductase 44
alanine aminotransferase 43
NMR 42
extracellular signal-regulated kinase 42
ERK1 42
ERK 41
p53 40
haptoglobin 40
collagen 40
IL-8 40
nuclear factor (erythroid-derived 2)-like 2 40
PI3K 39
cytochrome c 39
JNK 38
TLR4 37
NF-E2 37
AP-1 36
ALA 36
TNF-alpha 36
NADPH-cytochrome P-450 reductase 35
albumin 35
ferrochelatase 35
Pseudomonas 35
NRF2 35
c-Jun 34
transferrin 34
aspartate aminotransferase 34
superoxide dismutase 1 33
chemokine 33
endothelial nitric oxide synthase 32
inducible form 32
AKT 30
p38 mitogen-activated protein kinase 30
hemopexin 29
delta-aminolevulinate synthase 28
AMP-activated protein kinase 28
ferredoxin 27
guanylyl cyclase 27
Kelch-like ECH-associated protein 1 27
eNOS 27
adiponectin 26
NADH 26
peroxidase 26
cytochrome b5 26
tumor necrosis factor alpha 26
transferrin receptor 26
erythropoietin 25
interferon 25
phosphatidylinositol 3-kinase 25
protein kinase B 25
matrix metalloproteinase 25
polypeptide 24
glutathione peroxidase 1 24
thioredoxin 24
xanthine oxidase 24
CPR 23
ATPase 23
neuronal nitric oxide synthase 23
Ang II 23
p45 22
EPR 22
IL-1 22
vascular endothelium 22
serum albumin 21
cyclooxygenase 2 21
endothelin-1 20
angiotensin II 20
interleukin 6 20
LDH 20
peroxisome proliferator-activated receptor gamma 19
NFE2L2 19
manganese superoxide dismutase 19
xenobiotic 19
peroxisome proliferator-activated receptor 19
ICAM-1 19
CYP1A1 18
MnSOD 18
HIF-1alpha 18
CD11b 18
calmodulin 18
gut 18
MCP-1 17
alkaline phosphatase 17
THP 17
aryl hydrocarbon receptor 17
proteasome 17
SDS 16
amyloid precursor protein 16
adhesion molecule 16
fibronectin 16
IFN-gamma 16
c-fos 16
interferon-gamma 16
GST 16
p62 16
more...
Disease
GSH 213
ischemia 189
cancer 146
hypertension 116
diabetes 108
tumor 91
Alzheimer's disease 85
atherosclerosis 79
stroke 75
hyperbilirubinemia 64
NAME 60
sepsis 57
sepsis 57
hepatocellular carcinoma 56
depression 40
obesity 38
cardiovascular disease 38
hyperglycemia 36
carcinogenesis 36
Parkinson's disease 34
cold 32
cerebral ischemia 30
cognitive impairment 29
anemia 28
malaria 27
asthma 24
iron overload 24
myocardial ischemia 23
B-cell lymphoma 23
sickle cell disease 22
preeclampsia 21
type 2 diabetes 21
neuroblastoma 21
myocardial infarction 21
metabolic syndrome 21
neonatal jaundice 20
pulmonary hypertension 19
cirrhosis 19
heart failure 18
chronic obstructive pulmonary disease 18
multiple sclerosis 18
proteinuria 17
pheochromocytoma 17
renal disease 17
colitis 17
leukemia 17
SDS 16
adenocarcinoma 16
carcinoma 16
vascular disease 15
plaque 15
breast cancer 15
osteoarthritis 15
tumor growth 14
diabetic nephropathy 14
infectious diseases 14
acute renal failure 14
porphyria 13
Mycobacterium 13
subarachnoid hemorrhage 13
lung cancer 13
fatty liver 13
liver disease 12
HSP 12
iron deficiency 12
arthritis 12
tuberculosis 12
Infection 12
colon cancer 11
rheumatoid arthritis 11
cardiomyopathy 11
dementia 11
glioma 11
PCC 10
hepatitis 10
inflammatory bowel disease 10
renal ischemia 10
virus infection 10
liver fibrosis 10
autoimmune disease 10
MCF 10
tumorigenesis 9
melanoma 9
Placenta 9
cholera 9
kernicterus 8
amyotrophic lateral sclerosis 8
cystic fibrosis 8
osteoporosis 8
coronary artery disease 8
glomerulosclerosis 8
lymphoma 8
HIV 8
hemolytic anemia 8
prostate cancer 8
uterus 8
heart disease 8
epilepsy 8
Evans 8
renal failure 8
dyslipidemia 8
cholestasis 8
endotoxic shock 7
immunodeficiency 7
type 1 diabetes 7
DMT1 7
lung disease 7
ovarian cancer 6
chronic pain 6
bacterial infection 6
non-small cell lung cancer 6
Gilbert 6
diphtheria 6
Krabbe disease 6
Blocking 6
emphysema 6
tumor progression 6
pulmonary edema 6
macular degeneration 6
systemic lupus erythematosus 6
acute pancreatitis 6
adult respiratory distress syndrome 6
glomerulonephritis 6
vitiligo 6
erythroleukemia 6
diabetic cardiomyopathy 6
portal hypertension 6
brain edema 6
cytomegalovirus 6
hypercholesterolemia 5
glioblastoma 5
abortion 5
hepatitis C 5
skin disease 5
pneumonia 5
mole 5
salmonellosis 5
Endothelial dysfunction 5
gastric cancer 5
arteriosclerosis 5
chronic renal failure 5
hemochromatosis 5
hepatic porphyria 5
psoriasis 5
thalassemia 5
dermatitis 5
ATM 5
encephalomyelitis 5
erectile dysfunction 5
cervical cancer 5
hyperlipidemia 5
colorectal cancer 5
MIP 5
cornea 5
acute myeloid leukemia 5
lupus 4
glaucoma 4
endometriosis 4
glucose intolerance 4
ventricular hypertrophy 4
more...
Symptom
pain 45
hyperoxia 25
anesthesia 21
seizures 19
starvation 8
functional recovery 8
hypothermia 7
respiratory distress 6
hypercapnia 6
erythema 5
collapse 5
weakness 4
tremor 4
vomiting 4
diarrhea 3
splenomegaly 3
acute stress 3
memory loss 3
bradykinesia 3
anorexia 3
skin damage 3
exhaustion 3
angina 3
acute pain 3
syncope 2
nausea 2
hepatomegaly 2
overweight 2
fatigue 2
acidity 2
analgesia 2
discomfort 2
abdominal pain 2
discomfort 2
prostration 1
spasticity 1
lassitude 1
ataxia 1
Peripheral neuropathic pain 1
shortness of breath 1
HSA 1
polyuria 1
sneezing 1
hepatosplenomegaly 1
tenesmus 1
low back pain 1
forgetfulness 1
dry skin 1
Neuropathic pain 1
hypocapnia 1
Drug
Heme 332
ROS 59
ALA 47
ascorbate 38
CoCl2 27
CoCl2 27
NADH 25
vitamin E 19
IFN-gamma 16
lysine 13
Dermatol 13
FAD 12
Cardiovasc 12
Glutathione 11
MAP 10
CSF 9
Angiotensin II 9
Arsenic trioxide 8
Nitric Oxide 7
ICI 7
Indomethacin 6
Gel 6
Mutagen 6
IL-2 5
nitroglycerin 4
Simvastatin 4
Cimetidine 4
Nephron 4
CPR 4
ZnO 4
Ethanol 4
Cimetidine 4
DNase I 4
TiO2 4
ZnCl2 3
Portal 3
Nephron 3
Sodium nitroprusside 3
ZnCl2 3
Photofrin 3
Monit 3
EE2 3
Glucagon 3
caffeine 3
Vitamin E 2
CTX 2
Glycyrrhiza 2
Ginseng 2
Kainic acid 2
Stannous chloride 2
Scopolamine 2
Ginger 2
CIA 2
ampicillin 2
Methylene blue 2
Vardenafil 2
Auranofin 2
Albumin 2
Paraffin 2
Glycerol 2
Cilostazol 2
MRC 2
Pravastatin 2
Neotrofin 2
PCB 2
Viagra 1
Lovastatin 1
Mesoheme 1
Viagra 1
Glucantime 1
Axitinib 1
CTX 1
Mevastatin 1
9-THC 1
Asperlin 1
Amlexanox 1
Levitra 1
p75 1
Asn 1
Itraconazole 1
Retinoic acid 1
3-Methyladenine 1
DEL 1
Glutethimide 1
Photofrin II 1
Silica 1
Tranilast 1
Pentostam 1
CAM 1
Asthma 1
Zevalin 1
Camphor 1
BoNT/A 1
Clopidogrel 1
-deoxyadenosine 1
Alanine 1
Butaprost 1
niacin 1
lactose 1
ETS 1
Duloxetine 1
Pronase 1
pyridoxal phosphate 1
Propofol 1
Domperidone 1
Dial 1
Aprotinin 1
Sorafenib 1
Vinpocetine 1
Tao 1
Deuterium oxide 1
ROX 1
Ketoconazole 1
GEO 1
Hypaque 1
Rutin 1
Parkin 1
Limonene 1
Fenoldopam 1
Kenyan 1
Glybenclamide 1
FeCl3 1
Aluminum chloride 1
Rosiglitazone 1
THF 1
Glutamic acid 1
MCZ 1
PTC 1
Solon 1
Vitamin A 1
Agomelatine 1
P-Nitrophenol 1
Pentaerythritol tetranitrate 1
Safflower 1
Vitamin K 1
KCL 1
MCZ 1
Camphor 1
Levitra 1
Gly-Tyr-Gly 1
TTC 1
Fraction 1
ABC 1
PE2 1
ADR 1
HPMPC 1
Bucillamine 1
Motexafin gadolinium 1
ADM 1
Gefitinib 1
Parkin 1
Hypaque 1
CTX 1
Rosuvastatin 1
NAG 1
NOV 1
Desferal 1
Epigallocatechin 1
Guanethidine 1
IFN-beta 1
more...
Enzyme
heme oxygenase 4196
superoxide dismutase 340
catalase 247
mitogen-activated protein kinase 205
NQO1 152
glutathione peroxidase 150
ALA synthase 138
guanylate cyclase 126
NO synthase 116
caspase-3 101
biliverdin reductase 101
protein kinase 93
peroxidase 90
glutathione S-transferase 69
alanine aminotransferase 64
gamma-glutamylcysteine synthetase 57
NADPH oxidase 56
lactate dehydrogenase 54
luciferase 54
glutathione reductase 54
NADPH oxidase 53
ERK 48
demethylase 46
aspartate aminotransferase 42
NOS 40
ferrochelatase 39
CPR 39
AMP-activated protein kinase 38
protein kinase C 33
ECH 25
xanthine oxidase 25
phosphatidylinositol 3-kinase 25
ATPase 24
delta-aminolevulinic acid dehydratase 19
collagenase 19
UDP-glucuronosyltransferase 19
AMPK 18
alkaline phosphatase 17
proteasome 17
creatine kinase 15
thioredoxin reductase 15
AMPK 15
PARP 14
NADPH-diaphorase 13
peroxiredoxin 12
diaphorase 12
GSK 12
soluble epoxide hydrolase 12
tyrosine hydroxylase 12
phosphoinositide 3-kinase 12
focal adhesion kinase 11
aryl hydrocarbon hydroxylase 11
reverse transcriptase 11
ceruloplasmin 10
renin 10
gamma-glutamyl transpeptidase 10
PKG 10
thrombin 10
ornithine decarboxylase 9
complex I 9
porphobilinogen deaminase 9
MAP 9
AST 8
IKK 8
MEK 8
uroporphyrinogen decarboxylase 8
ascorbate peroxidase 7
ACS 7
aldehyde dehydrogenase 7
adenylate cyclase 7
trypsin 7
aldehyde dehydrogenase 7
caspase-9 7
aldehyde dehydrogenase 7
ACE 7
aldehyde dehydrogenase 7
glutathione synthetase 7
aldehyde dehydrogenase 7
RNA polymerase 7
indoleamine 2,3-dioxygenase 6
acetylcholinesterase 6
paraoxonase 6
phosphodiesterase 6
cystathionine gamma-lyase 6
adrenodoxin reductase 6
lipase 6
paraoxonase 6
acid phosphatase 5
squalene epoxidase 5
coproporphyrinogen oxidase 5
phospholipase C 5
cystathionine beta-synthase 5
phycocyanobilin:ferredoxin oxidoreductase 5
MIP 5
glyceraldehyde-3-phosphate dehydrogenase 5
tryptophan 2,3-dioxygenase 5
myrosinase 5
monoamine oxidase 5
prolyl hydroxylase 5
MMP-3 5
TdT 5
cysteine synthase 5
ferredoxin reductase 5
glucose-6-phosphatase 5
calcineurin 4
NADH-cytochrome b5 reductase 4
lysozyme 4
aconitase 4
glutamine synthetase 4
microsomal epoxide hydrolase 4
cytochrome oxidase 4
lipoxygenase 4
glucose oxidase 4
RNase 4
phospholipase A2 4
RNase 4
arginase 4
endonuclease 3
15-lipoxygenase 3
glucose-6-phosphate dehydrogenase 3
fumarase 3
protochlorophyllide oxidoreductase 3
choline acetyltransferase 3
elastase 3
glyceraldehyde-3-phosphate dehydrogenase 3
MPP 3
CaMKII 3
CYP3A4 3
beta-galactosidase 3
AMP-activated kinase 3
thromboplastin 3
S-adenosylmethionine decarboxylase 3
dihydrofolate reductase 3
caspase-8 3
glyceraldehyde-3-phosphate dehydrogenase 3
tissue plasminogen activator 3
APC 3
transcriptase 3
caspase-1 3
porphobilinogenase 3
transketolase 2
DNase 2
transaldolase 2
enolase 2
DMT 2
protoporphyrinogen oxidase 2
PAH 2
PDE 2
chaperonin 2
succinate dehydrogenase 2
HY2 2
NADH dehydrogenase 2
glutaminase 2
acetyl-CoA carboxylase 2
beta-glucuronidase 2
Mg-chelatase 2
methionine synthase 2
neuraminidase 2
angiotensin-converting enzyme 2 2
Thy1 2
more...
Compound
CO2 831
oxygen 792
iron 612
nitric oxide 456
Heme 361
zinc 305
Dec 293
tin 283
DNA 239
GSH 218
GSH 218
hydrogen 181
sodium 174
water 172
TNF 160
cobalt 148
cGMP 145
arginine 137
NADPH 134
NADPH 133
glucose 131
cysteine 128
Clin 118
glutamate 107
NAD 96
NAD 96
H2O2 94
cadmium 83
nitrogen 77
calcium 75
chromium 72
His 63
Hemin 61
phosphate 60
ATP 60
delta-aminolevulinic acid 60
Hemin 56
Hemin 56
Hemin 56
Hemin 56
creatinine 50
Protoporphyrin IX 48
N-acetylcysteine 48
salt 47
ethanol 47
Tin 46
acetate 43
copper 39
Bilirubin 38
MTT 36
H2S 36
Biliverdin 36
GSSG 35
urea 34
Zinc protoporphyrin 32
potassium 31
tryptophan 31
nicotinamide 31
tryptophan 31
tryptophan 31
tryptophan 31
aniline 31
superoxide radical 31
sulfate 30
cyanide 30
alanine 29
selenium 29
tyrosine 28
methionine 28
pyrene 28
cAMP 27
Curcumin 26
NADH 25
manganese 24
glycerol 24
8-OHdG 23
MDA 23
PGE 23
GMP 22
dUTP 22
nitrate 21
Resveratrol 20
Cobalt 19
Hemoglobin 18
Ang II 18
PGE2 18
Cereb 17
galactose 17
THP 17
THP 17
lysine 17
H2S 16
SDS 16
DMSO 15
NH2 15
serine 15
pyridine 15
PGJ2 15
retinoic acid 14
CAT 14
CAT 14
AMP 14
PEG 14
CAT 14
CCl4 13
aldehyde 13
CdCl2 13
homocysteine 13
Glutamate 13
threonine 13
hydroxide 12
bromide 12
chalcone 12
leucine 12
bromobenzene 12
BSO 12
vinyl 12
proline 12
FAD 12
ADP 11
tert-butyl hydroperoxide 11
FMN 11
iodine 11
nickel 11
aldehyde 11
diacetate 11
NADP 11
ammonium 10
prostacyclin 10
DEAE 10
ADP 10
Sulforaphane 10
ADP 10
Gly 10
Cardiol 10
Asp 10
Insulin 10
PEG 9
COX 9
benzene 9
silver 9
methanol 9
mercury 9
APAP 9
STZ 9
MAP 9
Angiotensin II 9
Succinylacetone 9
noradrenaline 9
UDP 8
2-nonenal 8
propionic acid 8
Lead 8
HgCl2 8
propionic acid 8
aluminum 8
ACh 8
Taurine 8
ADR 7
1-chloro-2,4-dinitrobenzene 7
more...