Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.14.99.3 (
heme oxygenase
)
4,196
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Based on our previous finding that
protease-activated receptor 2
(
PAR-2
) regulates hemophagocytosis of oral squamous cell carcinoma (SCC) cells, which induces their
heme oxygenase
1-dependent keratinization, we have formulated a hypothesis that
PAR-2
functions in wider activities of SCC cells. To confirm this hypothesis, we investigated immunohistochemical profiles of
PAR-2
in oral SCC tissues and its functional roles in cell proliferation and invasion in SCC cells in culture. The
PAR-2
expression modes were determined in 48 surgical tissue specimens of oral SCC. Using oral SCC-derived cell systems, we determined both gene and protein expression levels of
PAR-2
. SCC cell proliferation and invasive properties were also examined in conditions in which
PAR-2
was activated by the synthetic peptide SLIGRL.
PAR-2
was immunolocalized in oral SCC and carcinoma in situ cells, especially in those on the periphery of carcinoma cell foci (100% of cases), but not in normal oral epithelia. Its expression at both gene and protein levels was confirmed in 3 oral SCC cell lines including ZK-1. Activation of
PAR-2
induced ZK-1 cell proliferation in a dose-dependent manner.
PAR-2
-activated ZK-1 cells invaded faster than nonactivated ones. The expression of
PAR-2
is specific to oral malignancies, and
PAR-2
regulates the growth and invasion of oral SCC cells.
...
PMID:Protease-activated receptor 2 modulates proliferation and invasion of oral squamous cell carcinoma cells. 2591 57
