Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.14.99.3 (
heme oxygenase
)
4,196
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
TPP
-Sn4+ was administered intraperitoneally (25 mg/kg body weight). The study was performed for 1-30 days. A day after administration the increase in the hemoprotein level 1.4 times was observed, as well as an increase in the level of p-hydroxylation of aniline. On 7-14 days the greatest increase in cytochrome P-450 content was observed. To clarity the mechanism of
TPP
-Sn4+ effect on cytochrome P-450, we studied its effect on the activity of
heme oxygenase
and LP rate. This compound is an inhibitor of
heme oxygenase
activity and reduces the rate of LP in the microsomes which regulates porphyrin metabolism in the organism.
...
PMID:[Tetraphenylporphyrin-Sn4+ induction of cytochrome P-450]. 271 64
