Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.14.16.2 (tyrosine hydroxylase)
 14,760 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
CDP2 11.1
tyrosine hydroxylase isoform 2 11.1
KIAA1024L 11.1
transmembrane protein 195 11.1
tyrosine hydroxylase 11.0
tyrosine 3-monooxygenase 11.0
TH protein 10.7
UBX domain protein 11 10.1
ARHGAP10 protein 10.1
tyrosinase precursor 10.1
protein kinase C alpha type 10.1
PTPRO protein 10.1
AMPA 3 10.1
paired-like homeodomain transcription factor 3 9.9
phenylethanolamine N-methyltransferase 9.6
tyrosine hydroxylase isoform 1 9.5
potassium channel 2 9.5
TPH1 protein 9.5
Transforming growth factor-beta 3 9.5
fibronectin leucine rich transmembrane protein 3 9.5
VIP2R 9.5
PNMT protein 9.4
Nurr1 9.1
neurexophilin 3 9.1
sonic hedgehog homolog 9.1
ubiquitin specific peptidase 24 9.1
amino acid hydroxylase 9.1
CDIPT 9.1
Phenylethanolamine N-methyltransferase 9.1
tryptophan 5-monooxygenase 9.0
dopamine beta-hydroxylase 8.9
vesicular monoamine transporter 2 8.9
dopa decarboxylase 8.9
SLC35D3 8.8
JPD 8.8
GABAA receptor alpha5 8.8
engrailed homeobox 1 8.8
dopamine and cAMP-regulated phosphoprotein of 32 kDa 8.7
GTP cyclohydrolase I 8.5
GCH 8.5
more...
Disease
Abnormal chorionic villi 11.1
Congenital aqueductal stenosis 10.1
Sensory neglect 10.1
Sympathetic paraganglioma 10.1
DYT14 9.5
Supranuclear ophthalmoplegia 9.5
Peripheral neuroblastoma 9.5
DYT4 8.6
DYT2 8.4
Chronic hypernatremia 8.3
NSD 8.3
GTP cyclohydrolase I deficiency 8.1
ASMD 7.9
DRD 7.9
Food hoarding 7.8
JPD 7.8
PARK10 7.6
Juvenile Parkinsonism 7.6
DYT7 7.6
Chronic hypotension 7.5
DSAP 7.4
hemiparkinsonism 7.4
Equine grass sickness 7.4
Carotid body 7.3
Carotid body 7.3
Carotid body 7.3
Neonatal hyperthyroidism 7.3
amphetamine psychosis 7.3
neoplasm of uncertain malignant potential 7.2
Amphetamine withdrawal 7.2
LI3 7.2
Morphine dependence 7.1
PARK4 7.1
PARK3 7.0
Iron deficiency without anemia 7.0
Olfactory nerve 7.0
PCBD 6.9
Succinic semialdehyde dehydrogenase deficiency 6.8
DYT11 6.8
glycopenia 6.7
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Symptom
Lightening 7.5
Circling 6.1
Postural tremor 5.9
bradykinesia 5.9
POA 5.8
Motor dysfunction 5.7
impaired motor coordination 5.5
Rest tremor 5.3
Deafferentation 5.3
Stepping 5.2
No toxic effect 4.7
Behavioral symptoms 4.7
dystonia 4.5
Excitability 4.3
cardiovascular impairment 4.3
motor symptom 4.2
muscle rigidity 4.2
functional recovery 4.0
loss of equilibrium 3.9
acute stress 3.9
abnormal gait 3.7
pachyonychia 3.6
adipsia 3.5
aphagia 3.5
abnormal breathing 3.3
loss of balance 3.3
despair 3.2
chorea 3.2
ACHE 3.2
athetosis 3.0
tremor 3.0
excessive sweating 2.9
neurological disability 2.8
fasciculation 2.7
intention tremor 2.6
incoordination 2.6
hypercapnia 2.6
hypersomnia 2.0
Decreased activity 2.0
ataxic gait 2.0
more...
Drug
Liver hydrolysate 10.1
Brocresine 8.5
3,4-Dihydroxyphenylalanine 8.1
Bupleurum root 7.9
Pitressin tannate 7.9
Ipecac syrup 7.5
BH4 7.4
Uncaria hook 7.3
Doca 7.2
L-tyrosine 7.0
Pramipexole 6.9
Pramipexole 6.8
Pentolinium 6.6
7-Nitroindazole 6.6
Deferoxamine mesylate 6.6
Lergotrile 6.6
Reserpine 6.5
Ddc 6.5
Fluspirilene 6.4
Betoptic 6.4
Benserazide 6.3
Tirilazad mesylate 6.3
Fidarestat 6.3
Fidarestat 6.3
Madopar 6.2
Apomorphine 6.2
Betoptic 6.2
Tirilazad mesylate 6.2
Manganese chloride 6.1
Nitisinone 6.1
EPL 6.0
Eldepryl 6.0
Azilect 5.8
Sinemet 5.6
Guanethidine 5.6
HCH 5.6
Sinemet 5.5
Epalrestat 5.5
Rasagiline 5.4
Tianma 5.3
more...
Enzyme
EC 2.1.1.29 11.1
tyrosine hydroxylase 11.1
phenylethanolamine N-methyltransferase 9.6
aromatic L-amino acid decarboxylase 9.3
dopamine beta-hydroxylase 9.2
pterin-4alpha-carbinolamine dehydratase 9.1
DOPA decarboxylase 8.7
tryptophan hydroxylase 8.5
GTP cyclohydrolase I 8.5
6-pyruvoyltetrahydropterin synthase 8.3
aspartate 1-decarboxylase 8.3
sepiapterin reductase 7.9
choline acetyltransferase 7.5
amine N-methyltransferase 7.5
phenylalanine hydroxylase 7.5
retinol saturase 7.4
cyclohydrolase 7.4
MPP 7.3
2',3'-cyclic nucleotide phosphohydrolase 7.3
proprotein convertase 2 7.3
dihydropteridine reductase 7.1
glutamate decarboxylase 6.8
tyrosine decarboxylase 6.7
DAT 6.6
phenol oxidase 6.5
alkylglycerol monooxygenase 6.5
alkene monooxygenase 6.4
catechol O-methyltransferase 6.2
NADPH-diaphorase 6.0
neurosin 6.0
MT 1 5.9
monoamine oxidase 5.8
catechol oxidase 5.6
decarbonylase 5.3
diaphorase 5.3
tyrosylprotein sulfotransferase 5.2
GABA transaminase 4.9
cathepsin X 4.9
STK 4.9
tyrosinase 4.8
more...
Compound
Gepefrine 10.5
Tetrahydroneopterin 10.1
H 44/68 9.6
6-methyltetrahydropterin 9.5
C9H17NO2 9.5
DOPA sulfate 9.5
Metyrosine 9.1
C9H17NO2 9.1
6R-BH4 8.9
6,7-dimethyl-5,6,7,8-tetrahydropteridine 8.8
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 8.7
Dopaquinone 8.6
MPTP 8.5
Cephaeline 8.5
Anonaine 8.5
1-methyl-1,2,3,6-tetrahydropyridine 8.4
1-benzyl-1,2,3,4-tetrahydroisoquinoline 8.4
Phenylethanolamine 8.3
4-phenyl-1,2,3,6-tetrahydropyridine 8.2
Biopterin 8.1
3-Chlorotyrosine 8.1
3,4-dihydroxyphenylalanine 8.0
6-Hydroxydopamine 8.0
Molindone 7.9
D-Tyrosine 7.9
3-O-Methyldopa 7.9
4-(2-aminoethyl)phenol 7.9
DBH 7.9
Dopa 7.8
Orobol 7.8
3-hydroxyphenylethylamine 7.6
Amdro 7.6
7,8-Dihydrobiopterin 7.6
1-Methyl-4-phenylpyridinium 7.6
Bruceine D 7.5
1-methyl-3,4-dihydroisoquinoline 7.5
1,2,3,6-tetrahydropyridine 7.5
1,2,3,6-tetrahydropyridine 7.5
MPP 7.4
4-methylphenylalanine 7.4
more...