Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.14.16.2 (
tyrosine hydroxylase
)
14,760
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effects of noscapine, a phthalide isoquinoline alkaloid, on dopamine biosynthesis and
tyrosine hydroxylase
(TH) activity in PC12 cells were investigated.
Noscapine
showed 74.6% inhibition on dopamine content in PC12 cells at a concentration of 20 muM. IC(50) of noscapine was 6.8 muM. TH activity was inhibited by the treatment of noscapine in PC12 cells (20.9% inhibition at 20 muM). Therefore, the inhibition of TH activity by noscapine might be involved in at least one component of the reduction of dopamine biosynthesis in PC12 cells.
...
PMID:Inhibitory effects of noscapine on dopamine biosynthesis in PC12 cells. 1898
