Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.14.16.2 (
tyrosine hydroxylase
)
14,760
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
alpha-Tocopherol concentrations in brain were reduced to 3% of control levels in rats fed a vitamin E deficient diet for 52 weeks.
Vitamin E deficiency
resulted in a 19-33% loss of
tyrosine hydroxylase
(TH) immunopositive neurones in the substantia nigra, but not in the adjacent ventral tegmental area, compared with controls.
Vitamin E deficiency
, however, did not reduce striatal dopamine concentrations or turnover. When antioxidant defence mechanisms are defective, as in chronic
vitamin E deficiency
, the nigrostriatal pathway may be affected by oxidative damage and this may have implications for Parkinson's disease.
...
PMID:Nigral dopaminergic cell loss in vitamin E deficient rats. 782 29
