Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.14.14.3 (luciferase)
 38,195 document(s) hit in 31,850,051 MEDLINE articles (0.03 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Mol 5138
UTR 2607
Sep 2517
fused 1133
ATP 1076
cytokine 984
Sp1 917
p53 820
AP-1 719
insulin 696
p65 683
catenin 639
IL-6 631
TNF 628
lipopolysaccharide 627
tumor necrosis factor 618
caspase-3 577
estrogen receptor 576
AKT 560
p38 559
MAPK 544
CCK 510
ERK 500
collagen 486
interferon 453
PI3K 450
c-Jun 430
ERK1 415
Bcl-2 414
osteosarcoma 400
kit 390
p21 386
vascular endothelial growth factor 370
AMP 352
androgen receptor 345
IFN 339
LPS 338
E-cadherin 338
JNK 327
STAT3 320
cyclin D1 320
CREB 294
IL-8 293
osteogenic 285
histone 284
glucocorticoid receptor 281
HEK 278
nuclear receptor 268
alkaline phosphatase 267
aryl hydrocarbon receptor 266
mTOR 264
Nrf2 260
polypeptide 248
TNF-alpha 246
inducible nitric oxide synthase 241
p50 239
interleukin-6 235
peroxisome proliferator-activated receptor 235
thymidine kinase 234
extracellular signal-regulated kinase 231
nuclear protein 230
EBP 230
THP 230
MEK 226
DNase I 223
CD4 217
endoplasmic reticulum 217
PTEN 217
ubiquitin 216
cyclooxygenase-2 216
Gen 215
ATPase 208
erythroid 207
matrix metalloproteinase 206
TLR4 197
histone deacetylase 197
tyrosine kinase 196
AS1 196
peroxisome proliferator-activated receptor gamma 193
c-fos 192
proteasome 192
TNM 191
annexin V 189
glycoprotein 187
Smad3 180
vimentin 180
chemokine 178
VEGF 172
zinc finger 172
cytochrome P450 171
STAT 171
RNase 171
transcriptional repressor 168
epidermal growth factor 167
xenobiotic 167
heme oxygenase-1 167
c-Myc 166
ADP 165
phosphatidylinositol 3-kinase 165
TGF-beta 162
phosphatase 162
transcriptional factor 162
transcriptional activator 160
SP1 160
lymphoid 159
thyroid hormone 158
gut 157
RIP 157
Smad2 156
N-cadherin 155
epidermal growth factor receptor 154
beta-catenin 154
ROS 154
RACE 153
scratch 151
PKC 150
COX-2 149
FMN 149
GAL4 148
angiotensin II 148
MMP-9 147
CYP1A1 145
DNA-binding domain 145
IkappaBalpha 144
mitogen-activated protein 143
NMR 141
PEG 141
osteocalcin 139
fibronectin 139
transcriptional regulator 137
progesterone receptor 136
IL-10 136
EMT 133
IFN-gamma 133
MMP9 132
p300 131
AP1 130
NAD 129
IL-4 129
IL-1 129
RNA-binding protein 128
lactate dehydrogenase 127
ACS 127
PC-3 126
cage 125
Rho 124
SMA 124
Ah receptor 123
pregnane X receptor 123
transactivator 122
signal transducer and activator of transcription 3 122
calcineurin 122
NADH 122
transforming growth factor-beta 120
IL-2 119
prolactin 119
GST 119
proto-oncogene 119
tumor necrosis factor alpha 118
p27 118
more...
Disease
cancer 5867
tumor 5485
breast cancer 1470
hepatocellular carcinoma 1375
tumorigenesis 1299
tumor growth 1262
carcinoma 787
carcinogenesis 751
MCF 693
prostate cancer 647
tumor progression 637
colorectal cancer 633
lung cancer 618
gastric cancer 606
glioma 582
adenocarcinoma 503
osteosarcoma 460
HIV 425
diabetes 405
squamous cell carcinoma 378
non-small cell lung cancer 374
colon cancer 372
melanoma 368
metastases 361
neuroblastoma 356
atherosclerosis 345
leukemia 341
ovarian cancer 316
cervical cancer 300
cytomegalovirus 270
glioblastoma 265
pancreatic cancer 262
ischemia 262
virus infection 238
immunodeficiency 232
Alzheimer's disease 231
hepatitis C 228
obesity 222
hypertension 201
AS1 196
liver cancer 192
renal cell carcinoma 183
osteoarthritis 181
stroke 178
bladder cancer 177
herpes simplex 177
infectious diseases 169
DDP 160
osteoporosis 159
lymphoma 159
type 2 diabetes 157
plaque 153
liver cancer 151
influenza 149
myocardial infarction 149
retinoblastoma 146
B-cell lymphoma 141
Parkinson's disease 136
rheumatoid arthritis 135
asthma 134
EMT 133
cold 130
Hepatocellular carcinoma 124
cardiovascular disease 124
hepatitis B 122
Osteosarcoma 121
Osteosarcoma 121
SCID 119
acute myeloid leukemia 118
endometrial cancer 118
heart failure 117
lung carcinoma 117
Epstein 115
Mycobacterium 114
tuberculosis 109
sepsis 108
diabetic nephropathy 106
sepsis 105
GSH 103
mammary tumor 102
Infection 102
epithelial ovarian cancer 101
multiple myeloma 100
AGS 96
brain tumor 94
primary tumor 93
aggressiveness 92
arthritis 89
glioblastoma multiforme 89
myocardial ischemia 89
hyperglycemia 88
uterus 87
vaccinia 84
preeclampsia 81
cerebral ischemia 81
liver fibrosis 80
MTS 76
cystic fibrosis 76
suicide 76
depression 75
choriocarcinoma 75
pheochromocytoma 73
esophageal cancer 71
Blocking 71
schizophrenia 69
stomatitis 69
dengue 68
thyroid cancer 68
hepatitis 67
fatty liver 67
malaria 66
heart disease 66
colitis 64
pertussis 64
AIDS 64
tumor angiogenesis 63
coronary artery disease 62
Rous sarcoma 62
SDS 62
NOD 62
esophageal cancer 61
multiple sclerosis 61
ATM 60
renal disease 60
CCD 59
chronic obstructive pulmonary disease 59
Kaposi's sarcoma 56
inflammatory bowel disease 56
NS3 56
CCD 56
Adenovirus 55
sarcoma 55
fibrosarcoma 54
diabetic retinopathy 53
tumor initiation 53
papillary thyroid cancer 52
hepatoblastoma 51
psoriasis 51
WT1 51
metabolic syndrome 51
autoimmune disease 49
acute myocardial infarction 49
oral cancer 48
Glioblastoma 48
acute lymphoblastic leukemia 47
skin cancer 47
renal cancer 46
SARS 45
anemia 45
Melanoma 45
acute promyelocytic leukemia 45
chronic myeloid leukemia 44
systemic lupus erythematosus 44
West 44
HCC 44
cirrhosis 44
epilepsy 43
medulloblastoma 43
embryonal carcinoma 43
polycystic ovary syndrome 42
more...
Symptom
pain 127
starvation 98
anesthesia 49
seizures 29
hyperoxia 28
diarrhea 26
functional recovery 26
respiratory distress 24
menopausal symptoms 18
collapse 15
Neuropathic pain 13
masculinization 11
Scratch 11
exhaustion 9
acidity 9
analgesia 8
ataxia 8
cachexia 7
arthralgia 7
weakness 7
tremor 7
pelvic pain 7
splenomegaly 6
vomiting 6
headache 6
overweight 6
low back pain 6
abdominal pain 6
dystonia 5
fatigue 5
myalgia 5
hot flashes 5
nausea 4
discomfort 4
discomfort 4
ACHE 4
hypothermia 4
cerebellar ataxia 4
hepatomegaly 4
skin damage 4
constipation 3
angina 3
polyuria 3
HSA 3
cough 3
dyspnea 3
memory loss 3
hypercapnia 3
bone pain 3
photophobia 2
neurological disability 2
female puberty 2
cancer pain 2
back pain 2
catarrh 2
paresis 2
chills 2
agitation 2
chronic constipation 1
physical appearance 1
productive cough 1
nasal discharge 1
nipple discharge 1
intention tremor 1
Poor sleep 1
Cushingoid 1
nipple discharge 1
DNA marker 1
Anoxia 1
Stiffness 1
dental pain 1
otalgia 1
acute stress 1
bitter taste 1
fasciculation 1
hypersomnia 1
abnormal gait 1
distraction 1
joint stiffness 1
Wind 1
Halo 1
No toxic effect 1
insomnia 1
flushing 1
erythema 1
neuralgia 1
twitching 1
thinning 1
dry eye 1
hoarseness 1
myoclonus 1
vertigo 1
hypoproteinemia 1
hot flushes 1
Cushingoid 1
urinary frequency 1
acute pain 1
leg pain 1
wheezing 1
colic 1
cardiovascular disability 1
abdominal discomfort 1
night sweats 1
Visceral pain 1
epigastric pain 1
Inflammatory pain 1
general problem 1
sneezing 1
neck pain 1
polydipsia 1
hypotonia 1
nasal congestion 1
ophthalmoplegia 1
loss of taste 1
photopsia 1
Drug
Gel 376
lysine 240
DNase I 231
Monit 191
ROS 154
ICI 145
IFN-gamma 128
NADH 123
IL-2 119
Dermatol 100
MAP 79
GEO 58
ETS 52
EE2 48
Cardiovasc 47
Heme 44
CSF 43
Forskolin 42
R1881 42
G418 39
Retinoic acid 36
Angiotensin II 35
IFN-beta 30
PCB 30
Leaf 29
Activin 28
PTH 26
lactose 26
Estrogens 25
caffeine 23
RFP 23
TAT 22
Kenyan 22
vitamin E 20
DHT 19
ADR 19
TTC 19
DHT 19
CoCl2 18
CoCl2 18
MRC 17
ascorbate 17
Growth hormone 17
Docetaxel 17
Arsenic trioxide 16
Asthma 16
Growth hormone 16
Ethanol 16
FAD 16
Asn 16
Taxol 15
Glutathione 15
VCR 15
Adenosine triphosphate 15
Mutagen 15
ROC 15
Glycyrrhiza 14
Adriamycin 14
Propofol 13
Spectrum 13
ABC 13
Glucagon 12
Gelatin 12
ampicillin 12
Fluorescein 12
IL-11 12
Alanine 12
DEX 12
Sorafenib 12
Rosiglitazone 12
Bortezomib 11
Simvastatin 11
HCH 11
ETA 11
Histamine 11
CAM 11
CTX 11
Albumin 10
Parkin 10
p75 10
Parkin 10
Spectrum 10
EPA 10
Nephron 10
Indomethacin 10
Nitric Oxide 10
G-CSF 9
Herceptin 9
uPA 9
VCR 9
AGG 9
Ranitidine 9
Biopolymers 8
Gefitinib 8
Optison 8
CCL 8
Imatinib 8
beta-Galactosidase 8
Raloxifene 7
-deoxyadenosine 7
DM1 7
Oxaliplatin 7
AraC 7
nitroglycerin 7
Doxycycline 7
Cetuximab 7
CTX 6
Glycerol 6
Emodin 6
Ginseng 6
Optison 6
Serum albumin 6
MgSO4 6
Vitamin A 6
CDP 6
Bifidobacterium 6
Emodin 6
CTX 6
Itraconazole 6
Lovastatin 6
PCP 6
Lactase 6
Vitamin E 5
ALA 5
Ouabain 5
anti-RSV 5
Tacrolimus 5
CTZ 5
Portal 5
TEL 5
Dihydrotestosterone 5
ADM 5
Casodex 5
Troglitazone 5
Fulvestrant 5
KGF 5
BH4 5
Vorinostat 4
TAK 4
Silica 4
Orphan 4
TAC 4
CTC 4
FLP 4
CaCl2 4
CaCl2 4
Bosentan 4
CPT-11 4
Fluorescein 4
citric acid 4
Artesunate 4
THF 4
Taxotere 4
Erlotinib 4
Zoledronic acid 4
Etoposide 4
Epigallocatechin 4
SiO2 4
Fragment 4
CaCl2 4
more...
Enzyme
luciferase 38195
mitogen-activated protein kinase 1613
firefly luciferase 1276
ERK 980
protein kinase 894
protein kinase C 478
focal adhesion kinase 446
caspase-3 410
MEK 370
beta-galactosidase 337
alkaline phosphatase 268
RNA polymerase 252
thymidine kinase 234
glutathione S-transferase 229
RNase 223
RNase 220
ATPase 218
reverse transcriptase 205
proteasome 201
calcineurin 185
phosphatidylinositol 3-kinase 166
IKK 157
catalase 150
ACS 137
superoxide dismutase 137
lactate dehydrogenase 134
chloramphenicol acetyltransferase 117
PARP 115
CYP3A4 104
NQO1 98
GSK 97
AMP-activated protein kinase 92
AMPK 89
NO synthase 88
collagenase 86
peroxidase 85
transcriptase 83
phospholipase C 81
caspase-9 80
phosphoinositide 3-kinase 76
adenylate cyclase 75
cdc2 72
DNase 71
prostate-specific antigen 69
thrombin 68
phosphodiesterase 63
NADPH oxidase 59
caspase-8 58
beta-glucuronidase 56
P-glycoprotein 55
DNA methyltransferase 54
heme oxygenase 54
tyrosine hydroxylase 53
aspartate aminotransferase 52
ribonuclease 51
ribonuclease 51
DNA polymerase 49
NADPH oxidase 49
endonuclease 48
alanine aminotransferase 48
MAP 48
AMPK 47
caspase-1 46
MEKK1 45
trypsin 45
topoisomerase 43
S1 nuclease 43
creatine kinase 43
NOS 41
renin 41
APC 40
phosphoenolpyruvate carboxykinase 40
GAS 40
pyruvate kinase 39
topoisomerase 39
aequorin 38
apyrase 36
phosphoenolpyruvate carboxykinase 35
phosphoenolpyruvate carboxykinase 35
protein phosphatase 2A 35
PDK1 34
glyceraldehyde-3-phosphate dehydrogenase 34
tyrosinase 34
phospholipase A2 34
gamma-glutamylcysteine synthetase 34
CaMKII 34
glutathione peroxidase 33
urokinase-type plasminogen activator 32
matrix metalloproteinase 9 31
lipoprotein lipase 31
MMP 31
alcohol dehydrogenase 30
ATP synthase 30
MMP-3 30
histone acetyltransferase 29
glucose-6-phosphate dehydrogenase 28
adenylate kinase 28
MPP 28
citrate synthase 27
flavin reductase 27
matrix metalloproteinase 2 27
guanylate cyclase 27
glyceraldehyde-3-phosphate dehydrogenase 27
CYP7A1 27
furin 26
MIP 26
CPT 25
dihydrofolate reductase 24
demethylase 24
aldehyde dehydrogenase 24
acyl-CoA synthetase 24
HK2 23
hexokinase 23
cytosine deaminase 23
ornithine decarboxylase 23
TAT 22
UDP-glucuronosyltransferase 22
acetyl-CoA carboxylase 21
MDR 21
complex I 21
glyceraldehyde-3-phosphate dehydrogenase 21
SPC 20
chaperonin 20
acyl-CoA oxidase 20
glyceraldehyde-3-phosphate dehydrogenase 19
lipase 19
glyceraldehyde-3-phosphate dehydrogenase 19
prolyl hydroxylase 19
PKG 19
CPT 18
aldehyde dehydrogenase 18
phosphoglycerate kinase 18
TdT 18
CPT 18
acetylcholinesterase 18
aldehyde dehydrogenase 18
aldehyde dehydrogenase 17
ribonucleotide reductase 17
acyl-CoA synthetase 17
aldose reductase 17
acid phosphatase 17
aldehyde dehydrogenase 17
neuraminidase 17
AST 16
beta-lactamase 16
CD10 16
prostaglandin synthetase 16
lysozyme 16
phenylethanolamine N-methyltransferase 15
malate dehydrogenase 15
ribonucleotide reductase 15
tissue plasminogen activator 15
monoamine oxidase 15
pyruvate carboxylase 15
cathepsin D 15
glutamine synthetase 15
histone demethylase 15
gamma-glutamyl transpeptidase 14
TSA 14
ACE 14
more...
Compound
DNA 5793
Dec 2608
MTT 1247
oxygen 1092
ATP 1081
glucose 972
cAMP 866
calcium 677
TNF 628
Clin 617
acetate 508
MDA 493
phosphate 440
water 427
AMP 361
tyrosine 356
COS 353
sodium 351
bromide 339
retinoic acid 336
lysine 309
nitric oxide 307
cysteine 264
arginine 255
serine 253
hydrogen 246
PEG 236
THP 230
THP 230
zinc 229
MEK 211
ethanol 205
iron 201
TNM 191
aldehyde 188
sulfate 181
aldehyde 180
ADP 180
PEG 173
alanine 171
tryptophan 170
ADP 167
ADP 165
leucine 165
PEI 157
PEI 157
NAD 151
FMN 151
PMA 148
ICI 145
galactose 144
His 143
methionine 141
salt 140
iodine 136
threonine 135
PMA 135
nitrogen 130
NAD 129
ACS 128
Insulin 127
ACS 127
vitamin D 127
DDP 123
H2O2 123
NADH 123
GSH 113
GSH 113
glutamate 109
NH2 105
Estrogen 103
Estrogen 96
FMNH 92
ATF 88
Vimentin 88
urea 87
potassium 85
PGE 85
Cardiol 84
Phe 82
TCDD 82
copper 78
cadmium 78
aldosterone 77
pyrene 76
MTS 76
N-acetylcysteine 75
Asp 75
Ang II 74
TPA 73
TPA 73
Dexamethasone 71
adenylate 69
pyrimidine 69
proline 68
ammonium 67
CoA 67
nicotinamide 67
pyrimidine 67
SDS 67
GTP 65
Gly 65
NADPH 65
NADPH 65
glycerol 64
CAT 64
CAT 64
CAT 64
PGE2 64
dUTP 63
DMSO 62
CO2 61
Thyroid 60
cGMP 60
glutamine 57
pyrrolidine 56
MAP 56
TSH 54
cobalt 52
methanol 52
tryptophan 52
tryptophan 51
tryptophan 51
TEM 51
pyrrolidine 50
Estradiol 49
FK506 48
decanal 46
decanal 46
Collagen 45
Heme 45
DOPE 45
Resveratrol 44
ACTH 44
Optimal 44
Angiotensin II 43
Forskolin 42
uridine 41
phenol 40
ADR 38
barium 38
Bisulfite 38
cyanide 37
kaempferol 37
Curcumin 36
ASA 36
A 1 35
Androgen 35
diacetate 35
5-FU 35
palmitic acid 35
nickel 35
anthracene 34
noradrenaline 34
Adriamycin 34
Panam 34
Pac 34
Mg2+ 33
Alizarin 33
adenosylmethionine 33
more...