Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.14.13.97 (CYP3A4)
 6,365 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

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Human Gene/Protein
orphan nuclear receptor PXR 12.3
CYP3A4 12.3
CYP3A7 11.8
CYP3A43 11.8
CYP3A5 11.6
cytochrome P450 CYP3A4 11.4
CYP2B6 11.4
CYP2C8 11.4
Cytochrome P450 4F12 11.3
TSPYL6 11.3
D14S1461E 11.3
DP97 11.3
CYP2A7P2 11.3
CYP3A43 protein 11.3
cytochrome P450, family 3, subfamily A, polypeptide 4 11.3
dioxin-inducible cytochrome P450 11.3
CYP2C18 11.2
CYP2C9 11.1
CYP2C19 11.0
CYB5D2 11.0
CYP1A2 10.8
CYP2D6 10.8
cytochrome P450 3A7 10.7
CYP2C18 protein 10.7
COQ10A 10.7
NR2A2 10.7
CYP2A6 10.7
S-mephenytoin 4-hydroxylase 10.6
BLMH 10.6
CYP4F12 10.5
CYP3A 10.4
CYP21A2 protein 10.3
2C18 10.2
CYP4A11 10.2
pregnane X receptor 10.1
mephenytoin 4'-hydroxylase 10.1
CYP2E1 10.0
HL14 10.0
UBC7 10.0
TST2 10.0
CYP2C 10.0
NR1I2 9.9
PXR 9.9
CYP2F1 9.8
CYP2J2 9.8
UDP-glucuronosyltransferase 2B7 9.8
SULT6B1 9.7
PCN1 9.7
GSTA4 protein 9.7
FMO 1 9.7
CYP4X1 9.6
CYP 9.6
CYP4F11 9.6
NR1I1 9.6
CYP2W1 9.5
FMO3 9.5
CYP4B1 9.5
TSPY-like 1 9.5
adenosine deaminase-like 9.5
HLM-2 9.5
IPO13 9.5
EBN1 9.5
CYP4F3 9.5
UGT1A4 9.5
UGT2B7 9.4
constitutive androstane receptor 9.4
FMO5 9.4
CYP4F2 9.3
17-beta-HSD 9.3
SULT1C3 9.3
GALK2 9.3
NR1I3 9.2
UGT1A3 9.2
FMO1 9.2
Ubc6p 9.2
CYB5A 9.2
CYP2C9 protein 9.2
SLCO1B3 9.2
CYP3 9.1
CYP2A7 9.1
more...
Disease
CYP3A4-V 11.7
Drug-Food Interaction 11.3
Subacute hepatic failure 11.3
Therapy-related acute myeloid leukemia and myelodysplastic syndrome 10.3
Secondarily generalized seizures 8.8
Acute myopathy 8.6
BFNC 8.3
Hepatic impairment 7.6
dermographia 7.2
metastatic adrenocortical carcinoma 7.1
Gingival hyperplasia 6.4
Opioid Withdrawal 6.4
sigmoiditis 6.4
Duodenum 6.3
Duodenum 6.3
AD3 6.3
HPC1 6.2
lymphoblastoma 6.0
MCL 6.0
dependent personality disorder 5.9
Diffuse panbronchiolitis 5.9
CHEST 5.8
Opioid use disorder 5.7
vascular ischemia 5.7
NNH 5.5
EIN 5.5
torsades de pointes 5.4
polydrug abuse 5.4
HRD 5.4
Chronic migraine 5.3
hypopharyngeal squamous cell carcinoma 5.3
Hepatotoxicity 5.3
melanosis coli 5.3
Demented 5.2
HBD 5.2
APOA1 5.2
renal impairment 5.0
adrenalitis 5.0
DHD 4.9
DHD 4.9
Lennox-Gastaut syndrome 4.8
AML/MDS 4.8
adrenocortical cancer 4.8
Vascular dementia 4.7
dyschromia 4.7
Small intestine 4.6
NAME 4.6
Lennox-Gastaut syndrome 4.5
hand-foot syndrome 4.5
Akathisia 4.5
Endometrium 4.5
vitamin B6 deficiency 4.4
Endometrium 4.4
stage IV NSCLC 4.4
Crigler-Najjar syndrome 4.4
gliosarcoma 4.4
hypoprothrombinemia 4.4
OHD 4.3
Enzyme inhibition 4.3
bipolar depression 4.3
NPC 4.3
drug-induced hepatitis 4.3
variegate porphyria 4.3
heroin abuse 4.2
XPD 4.1
neonatal abstinence syndrome 4.1
ornithine transcarbamylase deficiency 4.1
STEMI 4.1
intestinal cancer 4.0
BEN 4.0
Stevens-Johnson syndrome 4.0
Ovarian Cancer 3.9
nasopharyngitis 3.9
zygomycosis 3.9
Candida albicans infection 3.9
mantle cell lymphoma 3.9
CDA 3.9
OCP 3.9
TMD 3.9
MPS VII 3.9
more...
Symptom
Severe diarrhea 6.5
Visual disturbances 5.5
peri-menopausal 4.8
Cushingoid 4.5
Cushingoid 4.5
ACHE 4.4
periorbital edema 4.3
abdominal cramps 4.2
Postoperative nausea and vomiting 4.2
nasal congestion 4.1
asthenia 3.9
dry skin 3.9
menopausal symptoms 3.6
breakthrough pain 3.6
syncopal episodes 3.3
lightheadedness 3.3
hot flashes 3.2
nausea 3.2
myalgia 3.1
nausea and vomiting 3.1
insomnia 3.0
dizziness 3.0
leg edema 2.9
flushing 2.8
sleepiness 2.8
constipation 2.8
chronic back pain 2.7
cancer pain 2.3
blurred vision 2.3
vomiting 2.2
decreased appetite 2.1
diarrhea 2.1
muscle stiffness 2.0
hot flushes 2.0
bitter taste 1.8
skin damage 1.7
headache 1.7
sciatica 1.7
despair 1.6
abdominal discomfort 1.5
incoordination 1.5
acute pain 1.3
twitching 1.3
skin irritation 1.2
angina 1.1
dysuria 1.0
analgesia 1.0
tremor 0.9
HSA 0.7
acidity 0.7
polyuria 0.7
seizures 0.6
splenomegaly 0.6
exertional dyspnea 0.6
fatigue 0.5
vertigo 0.5
arthralgia 0.5
memory loss 0.5
hemiplegia 0.3
pelvic pain 0.3
pain 0.3
weakness 0.2
abdominal pain 0.2
syncope 0.1
paresthesia 0.0
numbness -0.0
shortness of breath -0.1
cachexia -0.2
cough -0.3
back pain -0.3
anesthesia -0.3
spasticity -0.4
tinnitus -0.4
anorexia -0.5
spasm -0.6
ataxia -0.7
dystonia -0.8
discomfort -1.2
discomfort -1.3
overweight -1.4
more...
Drug
Tazofelone 12.3
Hectorol 11.3
Lurasidone hydrochloride 11.3
Posicor 11.3
Exatecan mesylate 11.3
Entocort EC 11.3
Oxantel pamoate 11.3
Carbazeran 10.7
Nalfurafine hydrochloride 10.5
Capravirine 10.3
AG-EE 388 ZW 10.0
Sulfaphenazole 9.6
Cerivastatin sodium 9.5
Serzone 9.5
Netupitant 9.4
Cerivastatin sodium 9.3
Relpax 9.3
Avasimibe 9.3
Ezlopitant 9.1
Fosamprenavir 9.0
Flexeril 9.0
Zedoary 9.0
Clast 9.0
Aprepitant 8.8
Ketoconazole 8.7
Propulsid 8.7
Glafenine 8.7
Pantoprazole sodium 8.7
Rifalazil 8.7
Etravirine 8.7
Tirilazad mesylate 8.5
Istradefylline 8.5
Stiripentol 8.5
Uncaria hook 8.5
Fluvoxamine maleate 8.5
Tirilazad mesylate 8.4
Roquinimex 8.4
Midostaurin 8.3
Romet 8.3
Azelastine hydrochloride 8.3
Bextra 8.1
Desvenlafaxine succinate 8.1
Lonafarnib 8.1
Medazepam 8.0
Galantamine hydrobromide 8.0
Elvitegravir 8.0
Ebastine 7.9
DB289 7.9
Rifater 7.9
TMC114 7.9
Rifater 7.8
Fluvoxamine maleate 7.8
Imidafenacin 7.8
Bosutinib 7.7
Tofisopam 7.7
Almotriptan 7.7
Iloperidone 7.7
Eletriptan 7.7
Alosetron 7.6
Motexafin gadolinium 7.6
Almotriptan 7.6
Axitinib 7.6
Nicardipine hydrochloride 7.5
Gliquidone 7.5
Lisofylline 7.5
Gestodene 7.5
Epinastine 7.5
Solifenacin succinate 7.5
Bromfenac 7.5
Omeprazole 7.3
Oxaprozin 7.3
Lumefantrine 7.3
Cinacalcet hydrochloride 7.3
Diethylpropion 7.2
Hyperforin 7.2
Spiriva 7.2
Trospium chloride 7.2
Dronedarone 7.2
Olopatadine hydrochloride 7.2
Mizolastine 7.2
more...
Enzyme
CYP3A4 12.3
quinine 3-hydroxylase 11.7
6beta-hydroxylase 10.9
N,O-acetyltransferase 9.0
CYP39A1 8.1
flavin-containing monooxygenase 8.1
CYP8B1 7.8
CYP46A1 7.6
CYP27A1 7.6
4-nitrophenol hydroxylase 7.5
UDP-glucuronosyltransferase 7.5
P-glycoprotein 7.4
aldehyde oxidase 7.1
aminocarboxymuconate-semialdehyde decarboxylase 7.0
microsomal epoxide hydrolase 6.9
GK2 6.8
cholesterol 25-hydroxylase 6.8
thiopurine methyltransferase 6.6
CYP7A1 6.4
CYP7B1 6.3
lanosterol 14alpha-demethylase 5.9
demethylase 5.9
carbonyl reductase 5.8
carboxylesterase 5.8
soluble epoxide hydrolase 5.5
tyrosine aminotransferase 5.3
shikimate dehydrogenase 5.1
LTA4 hydrolase 5.1
glycine amidinotransferase 5.0
PST 4.9
CPT 4.7
squalene epoxidase 4.7
SNO 4.7
aldehyde dehydrogenase 4.7
MDR 4.7
dihydropyrimidine dehydrogenase 4.6
CPT 4.6
cruzipain 4.5
NAT 4.5
CPM 4.5
HIV-1 protease 4.4
DMT 4.4
dihydropyrimidine dehydrogenase 4.3
AGT 4.3
TGT 4.3
ADH3 4.3
CPT 4.2
dipeptidyl peptidase IV 4.2
3-hydroxy-3-methylglutaryl-CoA reductase 4.2
thromboxane synthase 4.2
1-hydroxylase 4.1
CPR 4.1
sucrase-isomaltase 4.1
CCS 4.1
succinic semialdehyde dehydrogenase 4.1
arylsulfatase 4.0
carbamoylphosphate synthetase 4.0
AST 4.0
ferredoxin reductase 4.0
aryl hydrocarbon hydroxylase 3.9
separase 3.9
ornithine transcarbamylase 3.9
3-hydroxy-3-methylglutaryl coenzyme A reductase 3.8
luciferase 3.8
nicotinamide phosphoribosyltransferase 3.8
prostacyclin synthase 3.7
N-acetyltransferase 3.7
glutathione S-transferase 3.6
CPS 3.6
reverse transcriptase 3.6
paraoxonase 3.5
Protein 2 3.5
NQO1 3.5
CGT 3.5
ALDH 3.5
glucosylceramide synthase 3.4
dihydroorotate dehydrogenase 3.3
dihydroorotate dehydrogenase 3.3
aldehyde reductase 3.3
aldehyde reductase 3.3
more...
Compound
Datiscetin 12.3
Rutaevin 11.3
Neoastilbin 11.3
2-chloro-N-(2,6-diethylphenyl)acetamide 10.9
Grandisin 10.7
2,5-dibenzylidenecyclopentanone 10.7
Isophosphoramide mustard 10.7
4-(4-chlorobenzyl)pyridine 10.7
CITCO 10.7
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde 10.6
dibenzo[a,j]acridine 10.3
epsilon-Viniferin 10.3
Sophoranone 10.3
Auriculasin 10.3
Troleandomycin 10.2
TTMS 10.1
Bergaptol 10.1
1,3-oxazolidine-2,4-dione 10.1
C19H18O3 10.0
C19H18O3 10.0
C19H18O3 10.0
C19H18O3 10.0
C19H18O3 10.0
C19H18O3 10.0
C19H18O3 10.0
2,6-dibenzylidenecyclohexanone 10.0
C19H18O3 10.0
C5H11NO 10.0
methyl diethyldithiocarbamate 10.0
2,2-diphenylbutanamide 10.0
C19H18O3 10.0
C19H18O3 10.0
C19H18O3 10.0
imidazo[2,1-b][1,3]thiazole-5-carbaldehyde 10.0
C19H18O3 10.0
C19H18O3 10.0
2-hydroxy-4-methoxybenzoic acid 10.0
C19H18O3 10.0
C19H18O3 10.0
C19H18O3 10.0
Hellebrigenin 9.7
Xanthotoxol 9.7
C19H18O3 9.7
Caulophylline 9.7
1-Methylxanthine 9.7
Cephaeline 9.7
C19H18O3 9.7
C19H18O3 9.5
Columbin 9.5
3-phenylacrylamide 9.5
Dinactin 9.5
Dihydrofisetin 9.5
Elemicin 9.5
Pregnane 9.3
1,2-dimethyl-3-phenylaziridine 9.3
C19H18O3 9.3
cyclopropylbenzene 9.3
Dictamnine 9.2
C4H6O6 9.1
4-Ipomeanol 9.1
Retronecine 9.1
Nomilin 9.0
C19H18O3 9.0
Isofenphos 9.0
Bufotalin 9.0
5-bromo-2-hydroxybenzaldehyde 9.0
Orphenadrine 8.9
1,2-naphthalenediol 8.9
Geissoschizine 8.8
Miltirone 8.8
Chloroacetanilide 8.8
2-methyl-2-cyclohexen-1-one 8.8
Delavirdine 8.8
Ketoconazole 8.8
5-aminopentanoic acid 8.8
Chlorzoxazone 8.8
Amprenavir 8.7
Ritonavir 8.7
Levallorphan 8.7
Bufuralol 8.7
more...