Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:1.14.13.97 (CYP3A4)
6,365 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein CYP3A4 6360 cytochrome P450 2379 CYP1A2 1440 CYP2D6 1413 CYP2C9 1298 CYP2C19 1130 P450 1024 CYP3A 920 CYP2B6 768 CYP3A5 724 CYP2E1 645 CYP 606 CYP2C8 533 microsomal 513 CYP1A1 471 P-glycoprotein 462 cytochrome 411 Sep 410 CYP2A6 400 pregnane X receptor 354 NADPH 304 Mol 257 Cytochrome P450 232 xenobiotic 222 ABCB1 192 CYP3A7 185 PXR 141 cytochrome P-450 134 albumin 131 constitutive androstane receptor 130 MDR1 126 UGT1A1 126 CYP1B1 125 CYP2C 122 reductase 119 P-gp 102 nuclear receptor 91 1A1 91 gut 85 UGT2B7 83 NMR 78 GSH 72 tyrosine kinase 70 UDP-glucuronosyltransferase 65 CAR 64 protease inhibitor 63 glycoprotein 60 ABCG2 59 aryl hydrocarbon receptor 59 OATP1B1 58 proton pump 55 vitamin D receptor 54 glucocorticoid receptor 52 UGT1A9 51 CYP2B 50 HMG-CoA reductase 49 cytochrome b5 48 CYP2C18 46 calcium channel 44 OATP1B3 43 CYP2J2 43 breast cancer resistance protein 42 endoplasmic reticulum 41 BCRP 41 SLCO1B1 41 cytokine 41 ABCC2 40 UGT1A4 39 NR1I2 38 insulin 38 UGT 38 oxidoreductase 37 GSTM1 37 organic anion transporting polypeptide 37 GSTP1 37 UGT1A6 37 UGT1A3 36 CYP24A1 36 FMO3 35 glutathione S-transferase 35 more...

Disease cancer 423 HIV 154 hepatocellular carcinoma 146 tumor 134 breast cancer 108 hypertension 89 GSH 72 diabetes 66 NAME 64 prostate cancer 61 immunodeficiency 60 carcinogenesis 57 depression 47 hepatitis C 42 schizophrenia 40 renal impairment 40 epilepsy 38 lung cancer 35 Alzheimer's disease 33 type 2 diabetes 32 MCF 32 myopathy 31 cirrhosis 31 liver disease 30 hypercholesterolemia 30 tuberculosis 30 adenocarcinoma 28 stroke 27 neutropenia 27 malaria 25 AIDS 25 non-small cell lung cancer 25 chronic myeloid leukemia 24 asthma 22 rheumatoid arthritis 22 rash 21 ovarian cancer 21 obesity 20 acute myeloid leukemia 19 leukemia 19 cholestasis 19 carcinoma 19 fatty liver 19 colorectal cancer 18 cardiovascular disease 17 hyperlipidemia 17 heart failure 17 renal cell carcinoma 16 tumor growth 15 major depressive disorder 15 coronary heart disease 14 anemia 14 multiple myeloma 14 dyslipidemia 14 melanoma 14 inflammatory bowel disease 14 erectile dysfunction 13 hepatitis B 13 hepatitis 13 gastroesophageal reflux disease 13 chronic pain 13 migraine 13 tumor progression 13 SAR 13 thrombocytopenia 13 torsades de pointes 13 liver cancer 13 chronic hepatitis 12 acute lymphoblastic leukemia 12 coronary artery disease 12 fits 12 mantle cell lymphoma 11 osteoporosis 11 peripheral neuropathy 11 hypoglycemia 11 metastatic breast cancer 11 myocardial infarction 11 liver cancer 11 dementia 11 virus infection 11 more...

Symptom pain 64 diarrhea 49 nausea 44 headache 36 vomiting 30 seizures 25 anesthesia 18 sleepiness 18 insomnia 17 nausea and vomiting 16 dizziness 15 fatigue 15 constipation 14 myalgia 11 analgesia 11 angina 9 weakness 9 flushing 9 asthenia 8 abdominal pain 7 tremor 7 acidity 5 nasal congestion 4 menopausal symptoms 4 cough 4 dry skin 3 splenomegaly 3 cancer pain 3 blurred vision 2 discomfort 2 vertigo 2 arthralgia 2 discomfort 2 acute pain 2 dyspnea 2 anorexia 2 hot flashes 2 ataxia 2 syncope 2 overweight 2 abdominal cramps 2 back pain 2 Severe diarrhea 1 Postoperative nausea and vomiting 1 skin damage 1 incoordination 1 Cushingoid 1 peri-menopausal 1 dysuria 1 memory loss 1 spasm 1 paresthesia 1 cachexia 1 pelvic pain 1 polyuria 1 skin irritation 1 syncopal episodes 1 collapse 1 Visual disturbances 1 bitter taste 1 hypothermia 1 decreased appetite 1 breakthrough pain 1 twitching 1 chest pain 1 lightheadedness 1 tinnitus 1 spasticity 1 dystonia 1 Cushingoid 1 periorbital edema 1 leg edema 1 abdominal discomfort 1 respiratory distress 1 exertional dyspnea 1 ACHE 1 shortness of breath 1 HSA 1 chronic back pain 1 numbness 1 more...

Drug caffeine 92 Ketoconazole 89 Monit 45 Tacrolimus 37 Omeprazole 33 Itraconazole 32 Clopidogrel 30 lysine 19 Simvastatin 19 ABC 19 Cardiovasc 18 Fluconazole 16 Glutathione 15 ADR 14 Docetaxel 14 CPT-11 14 Aprepitant 14 Portal 13 vitamin E 13 Imatinib 12 Troglitazone 11 ROC 11 Leaf 11 Gefitinib 11 Domperidone 11 Glycyrrhiza 11 Fentanyl 9 ROS 9 Erlotinib 9 Irinotecan 9 Phenytoin 9 ATV 8 MAP 8 Taxol 8 Bosentan 8 EE2 8 CTX 8 Bosentan 8 CPR 8 Dasatinib 7 Mutagen 7 Cimetidine 7 Etravirine 7 Vitamin E 7 Cimetidine 7 Pravastatin 7 Posaconazole 6 Zonisamide 6 Sorafenib 6 Mirtazapine 6 TAK 6 Etoposide 6 IL-2 6 Gemfibrozil 6 Axitinib 5 Sulfaphenazole 5 Rosuvastatin 5 Asn 5 Maraviroc 5 Loratadine 5 DEX 5 NADH 5 Codeine 5 Dronedarone 5 Albumin 5 Cisapride 5 Ginseng 5 Codeine 5 Dermatol 4 Donepezil 4 Raloxifene 4 Almotriptan 4 Stiripentol 4 Hyperforin 4 Lovastatin 4 Vitamin K 4 Artemether 4 CDP 4 Everolimus 4 Vardenafil 4 more...

Enzyme CYP3A4 6365 P-glycoprotein 462 UDP-glucuronosyltransferase 116 luciferase 104 reverse transcriptase 75 demethylase 65 flavin-containing monooxygenase 60 glutathione S-transferase 54 ERK 53 6beta-hydroxylase 49 alanine aminotransferase 48 aspartate aminotransferase 36 carboxylesterase 33 acetylcholinesterase 31 catalase 29 aldehyde dehydrogenase 27 calcineurin 25 phosphodiesterase 24 MDR 23 ATPase 23 CYP27A1 21 focal adhesion kinase 21 soluble epoxide hydrolase 20 aldehyde oxidase 20 microsomal epoxide hydrolase 19 AST 19 CPR 18 CPT 17 CPT 17 CPT 17 protein kinase 17 superoxide dismutase 17 CYP7A1 17 cholinesterase 17 mitogen-activated protein kinase 16 renin 16 thromboplastin 14 ACS 14 NQO1 14 proteasome 13 peroxidase 12 alcohol dehydrogenase 12 thiopurine methyltransferase 11 monoamine oxidase 11 tyrosine aminotransferase 10 caspase-3 9 HIV-1 protease 9 creatine kinase 9 APC 9 xanthine oxidase 8 aldehyde dehydrogenase 8 aldehyde dehydrogenase 8 ACE 8 topoisomerase 8 aldehyde dehydrogenase 8 protein kinase C 8 thrombin 8 transcriptase 8 aldehyde dehydrogenase 8 CYP46A1 7 lactate dehydrogenase 7 collagenase 7 topoisomerase 7 RNase 6 MEK 6 RNase 6 carbonyl reductase 6 alkaline phosphatase 6 glutathione peroxidase 6 trypsin 6 N-acetyltransferase 6 RNA polymerase 6 dipeptidyl peptidase IV 6 glyceraldehyde-3-phosphate dehydrogenase 5 aryl hydrocarbon hydroxylase 5 urokinase-type plasminogen activator 5 ornithine transcarbamylase 5 dihydropyrimidine dehydrogenase 5 guanylate cyclase 5 PST 5 more...

Compound Clin 648 Dec 460 NADPH 304 NADPH 304 DNA 237 Diabetol 164 water 136 caffeine 92 oxygen 90 Ketoconazole 89 GSH 85 GSH 85 uridine 68 glucose 67 urea 67 hydrogen 65 vitamin D 63 Rifampicin 63 UDP 61 phosphate 61 sodium 60 iron 57 nitrogen 55 ethanol 55 sulfate 53 aflatoxin B1 48 calcium 48 Midazolam 48 cysteine 45 pyridine 44 FK506 43 acetonitrile 42 APAP 40 methanol 37 acetate 35 Ritonavir 34 DMSO 33 Omeprazole 33 MTT 32 tyrosine 31 creatinine 31 Tamoxifen 31 Tamoxifen 31 nicotinamide 30 ATP 30 Testosterone 30 Testosterone 30 pyrene 29 retinoic acid 28 aldehyde 28 Phe 27 Quinidine 26 Methadone 26 Cyclosporine 26 aldehyde 26 ABL 26 5-HT 25 MDR 25 piperazine 24 lysine 24 SN-38 23 Curcumin 23 piperidine 23 piperidine 23 threonine 22 CO2 21 Paclitaxel 21 phenol 21 CITCO 21 Voriconazole 20 UGA 20 aniline 20 ADP 20 Atorvastatin 20 Nifedipine 19 4-chlorophenyl 19 ADR 19 potassium 19 4-chlorophenyl 19 TNF 19 more...

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