Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.14.13.39 (
NO synthase
)
15,778
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
nitric oxide synthase
14318
lipopolysaccharide
1523
Sep
1193
cytokine
862
tumor necrosis factor
780
Mol
740
inducible nitric oxide synthase
640
NADPH
637
guanylate cyclase
627
cyclooxygenase
545
LPS
508
superoxide dismutase
482
eNOS
449
IFN-gamma
445
neuronal nitric oxide synthase
429
TNF
415
interferon-gamma
406
cyclooxygenase-2
401
calmodulin
398
insulin
394
ATP
393
bradykinin
343
soluble guanylyl cyclase
327
IL-6
323
angiotensin II
317
TNF-alpha
316
A-I
313
p38
283
guanylyl cyclase
249
interferon
246
diaphorase
245
catalase
245
p65
240
vascular endothelium
230
hemoglobin
221
IFN
207
phosphodiesterase
202
endothelin-1
196
heme oxygenase-1
195
NMDA receptor
195
COX-2
182
caspase-3
182
substance P
178
vascular endothelial growth factor
176
IL-10
174
renin
166
SIN
162
mitogen-activated protein
156
Ang II
155
interleukin-6
154
myeloperoxidase
154
collagen
153
reductase
153
ERK1
147
PKG
143
gut
141
tumor necrosis factor alpha
140
NOS2
139
MAPK
138
inducible form
138
NO3
131
extracellular signal-regulated kinase
129
GSH
126
xanthine oxidase
124
SOD
122
phosphatidylinositol 3-kinase
122
IL-1
121
olfactory
119
tyrosine hydroxylase
119
IL-1 beta
117
calcitonin
115
SNAP
112
constitutive nitric oxide synthase
111
cytochrome c
110
TLR4
108
DAF
107
ATPase
107
polypeptide
105
tyrosine kinase
105
IL-4
104
more...
Disease
NAME
2488
hypertension
1083
ischemia
596
diabetes
502
atherosclerosis
372
tumor
306
cancer
300
sepsis
263
sepsis
257
cardiovascular disease
229
stroke
207
depression
171
heart failure
164
pulmonary hypertension
146
cerebral ischemia
134
Alzheimer's disease
127
GSH
126
obesity
121
Endothelial dysfunction
107
asthma
106
vascular disease
103
myocardial ischemia
102
hyperglycemia
101
hypercholesterolemia
98
myocardial infarction
86
Parkinson's disease
86
type 2 diabetes
84
colitis
80
carcinogenesis
76
Mycobacterium
70
renal disease
69
cold
69
arthritis
67
tumor growth
63
pertussis
62
preeclampsia
62
erectile dysfunction
61
proteinuria
58
multiple sclerosis
58
coronary artery disease
57
metabolic syndrome
55
infectious diseases
55
Evans
54
cirrhosis
54
endotoxic shock
54
rheumatoid arthritis
54
renal failure
53
ventricular hypertrophy
52
tuberculosis
52
ATM
52
inflammatory bowel disease
51
Blocking
51
encephalomyelitis
49
virus infection
48
neuroblastoma
47
Huntington's disease
47
type 1 diabetes
46
malaria
45
SEM
43
plaque
42
Infection
39
essential hypertension
39
epilepsy
38
uterus
38
leishmaniasis
38
chronic renal failure
38
ulcerative colitis
38
migraine
37
osteoarthritis
37
melanoma
37
congestive heart failure
36
glioma
35
adenocarcinoma
35
pulmonary edema
34
glomerulonephritis
32
hepatocellular carcinoma
32
tumorigenesis
30
fits
30
pneumonia
30
varices
30
more...
Symptom
pain
143
seizures
98
anesthesia
90
hypothermia
40
hyperoxia
39
diarrhea
34
hypercapnia
34
collapse
23
headache
20
analgesia
19
respiratory distress
19
functional recovery
18
fatigue
16
starvation
13
spasm
12
angina
11
cachexia
11
exhaustion
9
tremor
9
cough
7
acute stress
7
splenomegaly
6
anorexia
6
constipation
6
polyuria
6
erythema
6
thinning
6
low back pain
5
ataxia
5
overweight
4
syncope
4
weakness
4
arthralgia
4
myalgia
4
vomiting
4
chest pain
4
hypocapnia
4
twitching
3
clonus
3
dizziness
3
sleepiness
3
flushing
3
spasticity
3
distraction
3
insomnia
3
Deafferentation
3
acidity
3
dystonia
3
neuralgia
3
acute pain
3
polydipsia
2
neck pain
2
discomfort
2
eds
2
agitation
2
Decreased activity
2
Gasping
2
HSA
2
memory loss
2
abnormal gait
2
tonic seizure
2
nausea
2
Neuropathic pain
2
incoordination
2
Ill
2
discomfort
2
back pain
2
dyspnea
2
Macula
2
abdominal pain
2
orofacial pain
2
rundown
2
myoclonus
2
skin damage
2
general problem
1
ENT
1
tenesmus
1
cerebellar ataxia
1
exertional dyspnea
1
muscle stiffness
1
more...
Drug
IFN-gamma
442
Cardiovasc
209
Nitric Oxide
208
lysine
163
BH4
126
Indomethacin
85
nitroglycerin
82
Sodium nitroprusside
74
FAD
72
ROS
67
Aminoguanidine
65
ascorbate
61
ICI
58
MAP
57
Angiotensin II
56
Methylene blue
52
IL-2
51
ETA
46
NADH
44
CSF
38
Nephron
33
vitamin E
31
Dermatol
26
Heme
26
caffeine
25
IFN-beta
24
Histamine
23
Gel
23
Ethanol
21
EE2
19
Simvastatin
18
7-Nitroindazole
16
Forskolin
15
Captopril
15
CTX
14
Nebivolol
12
Ringer's solution
11
Vitamin E
11
Atropine
10
Glutathione
10
EPA
10
Pravastatin
9
Estrogens
9
Asthma
9
Kainic acid
9
Molsidomine
8
ampicillin
8
Bosentan
8
Bosentan
8
Portal
8
Fructose
8
Nephron
7
Viagra
7
PCP
7
Viagra
7
Glucagon
6
Ginseng
6
Clonidine
6
Dial
6
CaCl2
6
CaCl2
6
IL-1ra
6
p75
6
CaCl2
6
ETS
5
Salicylate
5
citric acid
5
Troglitazone
5
CCL
5
THF
5
Leaf
5
Cilostazol
5
Phentolamine
5
Valsartan
5
Rosuvastatin
5
CTX
5
Ouabain
5
CTX
5
Secretin
4
Iloprost
4
more...
Enzyme
NO synthase
15778
NADPH-diaphorase
1564
NOS
1113
guanylate cyclase
879
mitogen-activated protein kinase
597
superoxide dismutase
545
protein kinase
498
NADPH oxidase
326
protein kinase C
274
diaphorase
267
arginase
266
NADPH oxidase
262
catalase
261
NQO1
256
diaphorase
245
peroxidase
205
phosphodiesterase
203
renin
166
ERK
147
caspase-3
144
PKG
143
xanthine oxidase
137
phosphatidylinositol 3-kinase
122
heme oxygenase
116
focal adhesion kinase
115
tyrosine hydroxylase
115
ATPase
110
glutathione peroxidase
95
AMP-activated protein kinase
91
MEK
88
luciferase
88
lactate dehydrogenase
84
reverse transcriptase
81
thrombin
79
ACE
78
phospholipase C
73
cytochrome oxidase
70
choline acetyltransferase
65
IKK
64
acetylcholinesterase
63
GTP cyclohydrolase I
62
nitrate reductase
59
nitrate reductase
58
nitrate reductase
58
nitrate reductase
58
nitrate reductase
58
nitrate reductase
58
alanine aminotransferase
55
adenylate cyclase
53
dimethylarginine dimethylaminohydrolase
53
calcineurin
51
phospholipase A2
50
phosphoinositide 3-kinase
49
AMPK
49
MAP
47
PARP
41
proteasome
38
ornithine decarboxylase
34
RNA polymerase
34
lipoxygenase
34
aspartate aminotransferase
34
alkaline phosphatase
32
PDE
30
glyceraldehyde-3-phosphate dehydrogenase
29
complex I
29
beta-galactosidase
28
RNase
28
argininosuccinate synthetase
28
RNase
28
glutathione S-transferase
27
creatine kinase
26
transcriptase
26
nitrite reductase
25
trypsin
25
nitrite reductase
25
nitrite reductase
25
CPR
25
glutathione reductase
23
AMPK
23
CaMKII
22
more...
Compound
nitric oxide
10943
arginine
5920
cGMP
1492
oxygen
1360
sodium
1301
calcium
1197
Dec
1188
nitrate
742
NADPH
638
NADPH
637
DNA
607
water
518
Clin
492
glucose
438
TNF
415
ATP
394
glutamate
348
nitrogen
337
phosphate
307
tyrosine
270
cAMP
261
CIT
258
salt
249
acetate
247
nicotinamide
236
GMP
230
ACh
227
potassium
211
iron
197
hydrogen
194
CO2
191
cysteine
187
noradrenaline
184
lysine
184
NO3
183
prostacyclin
173
NMDA
172
PGE
172
ornithine
170
ornithine
170
ornithine
170
ornithine
170
ornithine
170
ethanol
151
serine
132
GSH
131
GSH
131
urea
124
Cardiol
117
ADP
110
H2O2
106
creatinine
102
PGE2
102
Neuronal
100
Nitrite
100
Nitrite
100
Ang II
98
ADP
96
ADP
96
GABA
94
GABA
94
diacetate
94
AMP
87
Nitro-L-arginine
87
threonine
86
sulfate
82
Angiotensin II
82
FMN
79
superoxide radical
79
Indomethacin
78
5-HT
77
N-acetylcysteine
75
Phe
75
zinc
75
alanine
74
FAD
72
galactose
72
Insulin
72
8-Br-cGMP
67
methionine
66
more...