Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.14.13.39 (
NO synthase
)
15,778
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
nitric oxide synthase
14318
lipopolysaccharide
1523
Sep
1193
cytokine
862
tumor necrosis factor
780
Mol
740
inducible nitric oxide synthase
640
NADPH
637
guanylate cyclase
627
cyclooxygenase
545
LPS
508
superoxide dismutase
482
eNOS
449
IFN-gamma
445
neuronal nitric oxide synthase
429
TNF
415
interferon-gamma
406
cyclooxygenase-2
401
calmodulin
398
insulin
394
ATP
393
bradykinin
343
soluble guanylyl cyclase
327
IL-6
323
angiotensin II
317
TNF-alpha
316
A-I
313
p38
283
guanylyl cyclase
249
interferon
246
catalase
245
diaphorase
245
p65
240
vascular endothelium
230
hemoglobin
221
IFN
207
phosphodiesterase
202
endothelin-1
196
NMDA receptor
195
heme oxygenase-1
195
more...
Disease
NAME
2488
hypertension
1083
ischemia
596
diabetes
502
atherosclerosis
372
tumor
306
cancer
300
sepsis
263
sepsis
257
cardiovascular disease
229
stroke
207
depression
171
heart failure
164
pulmonary hypertension
146
cerebral ischemia
134
Alzheimer's disease
127
GSH
126
obesity
121
Endothelial dysfunction
107
asthma
106
vascular disease
103
myocardial ischemia
102
hyperglycemia
101
hypercholesterolemia
98
Parkinson's disease
86
myocardial infarction
86
type 2 diabetes
84
colitis
80
carcinogenesis
76
Mycobacterium
70
cold
69
renal disease
69
arthritis
67
tumor growth
63
preeclampsia
62
pertussis
62
erectile dysfunction
61
proteinuria
58
multiple sclerosis
58
coronary artery disease
57
more...
Symptom
pain
143
seizures
98
anesthesia
90
hypothermia
40
hyperoxia
39
diarrhea
34
hypercapnia
34
collapse
23
headache
20
respiratory distress
19
analgesia
19
functional recovery
18
fatigue
16
starvation
13
spasm
12
angina
11
cachexia
11
tremor
9
exhaustion
9
acute stress
7
cough
7
splenomegaly
6
erythema
6
polyuria
6
constipation
6
thinning
6
anorexia
6
low back pain
5
ataxia
5
vomiting
4
weakness
4
syncope
4
overweight
4
myalgia
4
hypocapnia
4
chest pain
4
arthralgia
4
sleepiness
3
dystonia
3
acute pain
3
more...
Drug
IFN-gamma
442
Cardiovasc
209
Nitric Oxide
208
lysine
163
BH4
126
Indomethacin
85
nitroglycerin
82
Sodium nitroprusside
74
FAD
72
ROS
67
Aminoguanidine
65
ascorbate
61
ICI
58
MAP
57
Angiotensin II
56
Methylene blue
52
IL-2
51
ETA
46
NADH
44
CSF
38
Nephron
33
vitamin E
31
Heme
26
Dermatol
26
caffeine
25
IFN-beta
24
Gel
23
Histamine
23
Ethanol
21
EE2
19
Simvastatin
18
7-Nitroindazole
16
Forskolin
15
Captopril
15
CTX
14
Nebivolol
12
Ringer's solution
11
Vitamin E
11
Glutathione
10
Atropine
10
more...
Enzyme
NO synthase
15778
NADPH-diaphorase
1564
NOS
1113
guanylate cyclase
879
mitogen-activated protein kinase
597
superoxide dismutase
545
protein kinase
498
NADPH oxidase
326
protein kinase C
274
diaphorase
267
arginase
266
NADPH oxidase
262
catalase
261
NQO1
256
diaphorase
245
peroxidase
205
phosphodiesterase
203
renin
166
ERK
147
caspase-3
144
PKG
143
xanthine oxidase
137
phosphatidylinositol 3-kinase
122
heme oxygenase
116
focal adhesion kinase
115
tyrosine hydroxylase
115
ATPase
110
glutathione peroxidase
95
AMP-activated protein kinase
91
MEK
88
luciferase
88
lactate dehydrogenase
84
reverse transcriptase
81
thrombin
79
ACE
78
phospholipase C
73
cytochrome oxidase
70
choline acetyltransferase
65
IKK
64
acetylcholinesterase
63
more...
Compound
nitric oxide
10943
arginine
5920
cGMP
1492
oxygen
1360
sodium
1301
calcium
1197
Dec
1188
nitrate
742
NADPH
638
NADPH
637
DNA
607
water
518
Clin
492
glucose
438
TNF
415
ATP
394
glutamate
348
nitrogen
337
phosphate
307
tyrosine
270
cAMP
261
CIT
258
salt
249
acetate
247
nicotinamide
236
GMP
230
ACh
227
potassium
211
iron
197
hydrogen
194
CO2
191
cysteine
187
noradrenaline
184
lysine
184
NO3
183
prostacyclin
173
PGE
172
NMDA
172
ornithine
170
ornithine
170
more...