Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.14.11.2 (prolyl hydroxylase)
1,814 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
collagen 562
prolyl 4-hydroxylase 447
PHD2 150
Mol 128
Sep 112
erythropoietin 109
vascular endothelial growth factor 106
Prolyl hydroxylase 103
HIF-1alpha 94
proline hydroxylase 84
HIF-1 84
polypeptide 79
endoplasmic reticulum 69
PHD3 67
lysyl hydroxylase 58
PHD1 56
PHD 54
proteasome 48
lysyl oxidase 42
collagenase 40
protein disulfide isomerase 37
hemoglobin 35
ubiquitin 34
VEGF 30
type I collagen 30
cytokine 28
pVHL 27
fibronectin 24
ATP 23
E3 ubiquitin ligase 23
ubiquitin ligase 22
p53 22
HIF-1 alpha 22
von Hippel-Lindau tumor suppressor 21
insulin 21
VHL 20
type I procollagen 20
glucose transporter 19
microsomal 19
alkaline phosphatase 19
more...
Disease
cancer 171
tumor 133
Hippel 120
anemia 109
ischemia 64
cirrhosis 46
tumor growth 37
stroke 34
tumorigenesis 32
tumor progression 30
liver fibrosis 30
hepatocellular carcinoma 30
breast cancer 28
pulmonary fibrosis 27
erythrocytosis 24
carcinoma 18
myocardial infarction 18
SDS 17
hypertension 16
liver disease 16
diabetes 16
atherosclerosis 14
pulmonary hypertension 14
polycythemia 12
hepatitis 12
melanoma 12
Alzheimer's disease 11
colitis 11
Parkinson's disease 10
tumor angiogenesis 10
cold 10
obesity 10
myocardial ischemia 10
cardiovascular disease 10
lung cancer 10
renal cell carcinoma 10
iron deficiency 10
rheumatoid arthritis 10
FIH 10
pheochromocytoma 9
more...
Symptom
starvation 10
hyperoxia 8
respiratory distress 6
pain 5
functional recovery 3
dyspnea 2
dysesthesia 2
hypothermia 2
hypotonia 2
thinning 2
diarrhea 2
cachexia 2
Cold intolerance 1
fatigue 1
polydipsia 1
numbness 1
anesthesia 1
nausea 1
back pain 1
splenomegaly 1
acidity 1
tremor 1
abdominal pain 1
hypercapnia 1
low back pain 1
paresthesia 1
twitching 1
collapse 1
polyuria 1
headache 1
hyperesthesia 1
fasciculation 1
Drug
ascorbate 94
lysine 41
Dermatol 18
CoCl2 13
CoCl2 13
Cardiovasc 10
Asn 8
Dial 7
NADH 6
Gel 6
CSF 5
ROS 5
Malotilate 3
Angiotensin II 3
Nitric Oxide 2
citric acid 2
Rosiglitazone 2
DNase I 2
MAP 2
Triclosan 2
EE2 2
niacin 2
Oxaliplatin 2
Heme 2
Phenytoin 2
CTX 1
OTC 1
Tranilast 1
Serum albumin 1
Glucagon 1
CAM 1
BLM 1
Albumin 1
CaCl2 1
EPI 1
CaCl2 1
ABC 1
OTC 1
Cetuximab 1
CTX 1
more...
Enzyme
prolyl hydroxylase 1814
lysyl hydroxylase 62
PHD 54
collagenase 49
proteasome 49
galactosylhydroxylysyl glucosyltransferase 42
lysyl oxidase 40
ERK 25
type III procollagen 21
luciferase 19
mitogen-activated protein kinase 19
alkaline phosphatase 19
superoxide dismutase 17
succinate dehydrogenase 16
peroxidase 16
pepsin 14
lactate dehydrogenase 13
protein disulfide-isomerase 13
trypsin 13
caspase-3 12
ACS 11
prolyl 3-hydroxylase 11
alanine aminotransferase 10
protein kinase 10
gamma-glutamyl transpeptidase 10
PDK1 10
phosphatidylinositol 3-kinase 9
protein kinase C 8
AMP-activated protein kinase 8
fumarase 7
hexokinase 7
NO synthase 7
focal adhesion kinase 6
creatine kinase 6
carbonic anhydrase 6
aspartate aminotransferase 6
thymidine kinase 6
heme oxygenase 5
tyrosine hydroxylase 5
catalase 5
more...
Compound
oxygen 446
proline 260
2-oxoglutarate 178
iron 167
Dec 132
DNA 107
Collagen 69
glucose 66
Clin 64
Hydroxyproline 57
lysine 52
4-hydroxyproline 44
4-hydroxyproline 44
4-hydroxyproline 44
4-hydroxyproline 44
4-hydroxyproline 44
4-hydroxyproline 44
Pro-Gly 34
pyridine 26
Ascorbic acid 26
cobalt 25
calcium 23
ATP 23
water 22
nitric oxide 22
alanine 20
phosphate 19
cysteine 19
leucine 19
sodium 18
arginine 18
salt 18
Gly 18
SDS 18
sulfate 17
zinc 17
asparagine 17
protocatechuate 17
CCl4 16
His 15
more...