Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.14.11.2 (
prolyl hydroxylase
)
1,814
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
collagen
562
prolyl 4-hydroxylase
447
PHD2
150
Mol
128
Sep
112
erythropoietin
109
vascular endothelial growth factor
106
Prolyl hydroxylase
103
HIF-1alpha
94
proline hydroxylase
84
HIF-1
84
polypeptide
79
endoplasmic reticulum
69
PHD3
67
lysyl hydroxylase
58
PHD1
56
PHD
54
proteasome
48
lysyl oxidase
42
collagenase
40
protein disulfide isomerase
37
hemoglobin
35
ubiquitin
34
VEGF
30
type I collagen
30
cytokine
28
pVHL
27
fibronectin
24
ATP
23
E3 ubiquitin ligase
23
ubiquitin ligase
22
p53
22
HIF-1 alpha
22
von Hippel-Lindau tumor suppressor
21
insulin
21
VHL
20
type I procollagen
20
glucose transporter
19
microsomal
19
alkaline phosphatase
19
more...
Disease
cancer
171
tumor
133
Hippel
120
anemia
109
ischemia
64
cirrhosis
46
tumor growth
37
stroke
34
tumorigenesis
32
tumor progression
30
liver fibrosis
30
hepatocellular carcinoma
30
breast cancer
28
pulmonary fibrosis
27
erythrocytosis
24
carcinoma
18
myocardial infarction
18
SDS
17
hypertension
16
liver disease
16
diabetes
16
atherosclerosis
14
pulmonary hypertension
14
polycythemia
12
hepatitis
12
melanoma
12
Alzheimer's disease
11
colitis
11
Parkinson's disease
10
tumor angiogenesis
10
cold
10
obesity
10
myocardial ischemia
10
cardiovascular disease
10
lung cancer
10
renal cell carcinoma
10
iron deficiency
10
rheumatoid arthritis
10
FIH
10
pheochromocytoma
9
more...
Symptom
starvation
10
hyperoxia
8
respiratory distress
6
pain
5
functional recovery
3
dyspnea
2
dysesthesia
2
hypothermia
2
hypotonia
2
thinning
2
diarrhea
2
cachexia
2
Cold intolerance
1
fatigue
1
polydipsia
1
numbness
1
anesthesia
1
nausea
1
back pain
1
splenomegaly
1
acidity
1
tremor
1
abdominal pain
1
hypercapnia
1
low back pain
1
paresthesia
1
twitching
1
collapse
1
polyuria
1
headache
1
hyperesthesia
1
fasciculation
1
Drug
ascorbate
94
lysine
41
Dermatol
18
CoCl2
13
CoCl2
13
Cardiovasc
10
Asn
8
Dial
7
NADH
6
Gel
6
CSF
5
ROS
5
Malotilate
3
Angiotensin II
3
Nitric Oxide
2
citric acid
2
Rosiglitazone
2
DNase I
2
MAP
2
Triclosan
2
EE2
2
niacin
2
Oxaliplatin
2
Heme
2
Phenytoin
2
CTX
1
OTC
1
Tranilast
1
Serum albumin
1
Glucagon
1
CAM
1
BLM
1
Albumin
1
CaCl2
1
EPI
1
CaCl2
1
ABC
1
OTC
1
Cetuximab
1
CTX
1
more...
Enzyme
prolyl hydroxylase
1814
lysyl hydroxylase
62
PHD
54
collagenase
49
proteasome
49
galactosylhydroxylysyl glucosyltransferase
42
lysyl oxidase
40
ERK
25
type III procollagen
21
luciferase
19
mitogen-activated protein kinase
19
alkaline phosphatase
19
superoxide dismutase
17
succinate dehydrogenase
16
peroxidase
16
pepsin
14
lactate dehydrogenase
13
protein disulfide-isomerase
13
trypsin
13
caspase-3
12
ACS
11
prolyl 3-hydroxylase
11
alanine aminotransferase
10
protein kinase
10
gamma-glutamyl transpeptidase
10
PDK1
10
phosphatidylinositol 3-kinase
9
protein kinase C
8
AMP-activated protein kinase
8
fumarase
7
hexokinase
7
NO synthase
7
focal adhesion kinase
6
creatine kinase
6
carbonic anhydrase
6
aspartate aminotransferase
6
thymidine kinase
6
heme oxygenase
5
tyrosine hydroxylase
5
catalase
5
more...
Compound
oxygen
446
proline
260
2-oxoglutarate
178
iron
167
Dec
132
DNA
107
Collagen
69
glucose
66
Clin
64
Hydroxyproline
57
lysine
52
4-hydroxyproline
44
4-hydroxyproline
44
4-hydroxyproline
44
4-hydroxyproline
44
4-hydroxyproline
44
4-hydroxyproline
44
Pro-Gly
34
pyridine
26
Ascorbic acid
26
cobalt
25
calcium
23
ATP
23
water
22
nitric oxide
22
alanine
20
phosphate
19
cysteine
19
leucine
19
sodium
18
arginine
18
salt
18
Gly
18
SDS
18
sulfate
17
zinc
17
asparagine
17
protocatechuate
17
CCl4
16
His
15
more...