Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.14.11.2 (prolyl hydroxylase)
 1,814 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

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Human Gene/Protein
proline hydroxylase 14.1
dihydropyrimidinase-like 2 variant 14.1
ER lipid raft associated 1 14.1
prolyl 4-hydroxylase 14.1
MAPK organizer 1 13.4
HPH-3 13.1
Prolyl hydroxylase 13.0
Prolyl 3-hydroxylase 12.8
P4HA3 12.7
PHD3 12.6
PHD2 12.4
Lysyl hydroxylase 12.3
PHD1 12.2
TBC1D16 12.1
transcription factor 17 12.1
FBLN5 protein 12.1
ACTIN-2 12.1
lysyl hydroxylase 12.1
EGLN3 12.0
P4HA2 11.9
BBAP 11.9
Prolyl hydroxylase domain-containing protein 2 11.8
type I collagen alpha 1 chain 11.8
transmembrane protein 127 11.8
glycerol-3-phosphate dehydrogenase 1-like 11.8
HPH2 11.7
P3H2 11.5
OGFOD1 11.5
EGLN2 11.4
Egl nine homolog 3 11.4
N-myc downstream-regulated gene 3 11.3
P4HA1 11.3
Cullin 2 11.3
seven in absentia homolog 2 11.3
LEPREL1 10.9
inhibitor of growth family member 4 10.9
candidate tumor suppressor protein 10.9
FLNA protein 10.9
ERLIN1 10.9
EDS VI 10.9
SPFH1 10.8
Peptidyl-prolyl cis-trans isomerase 10.8
C17orf32 10.8
CCDC115 10.8
ERp60 10.7
cartilage-associated protein 10.7
surfactant protein A1 10.6
FIH1 10.6
EDHB 10.6
Inhibitory PAS domain protein 10.6
HA95 10.6
GKD 10.6
FIH-1 10.6
KIF1Bbeta 10.5
EDR3 10.5
glutathione-insulin transhydrogenase 10.5
Deoxyhypusine hydroxylase 10.3
Type XIII collagen 10.3
PCBP3 10.3
P4HB 10.3
Protein disulfide-isomerase 10.3
magnesium transporter 1 10.3
RCC4 10.3
P3H1 10.2
PHD 10.2
PCBP4 10.2
EPI64C 10.1
APPBP1 10.1
RPS23 10.1
ISLR 10.1
Death-associated protein 5 10.0
HIF2A 10.0
PH4 10.0
Insulin receptor substrate-2 9.9
cyclin dependent protein kinase 9.9
von Hippel-Lindau tumor suppressor 9.9
mutant VHL 9.8
Thrombospondin-2 9.7
CANX 9.7
pVHL 9.7
HIF-1alpha 9.7
patched homolog 1 9.6
Cullin-1 9.6
ENaCalpha 9.6
PPM1G 9.6
calcyphosine 9.6
ARFGEF2 9.6
putative zinc finger protein 9.6
EDR1 9.5
alpha1(I) procollagen 9.5
ubiquitin-specific processing protease 9.5
HCC1 9.5
HIF1 9.5
ALFY 9.5
CHCHD4 9.5
HIF-1beta 9.4
HIF-1 alpha 9.4
RBM38 9.4
RIPK4 9.4
ABH2 9.4
lysozyme 2 9.4
FOLR2 9.4
AZI1 9.4
ST8SIA1 9.4
14-3-3 gamma 9.3
PPCS 9.3
ALKBH3 9.3
HIF-1 9.3
COL13A1 9.3
Lysyl hydroxylase 3 9.3
3-hydroxyanthranilate 3,4-dioxygenase 9.2
lysyl hydroxylase 2 9.2
type XIII collagen 9.2
alkaline ceramidase 2 9.2
ODD 9.2
disulfide isomerase 9.2
WDFY3 9.1
beta polypeptide 9.1
RNH1 9.1
Discoidin domain receptor 2 9.1
JMJD5 9.1
DNASE1 9.1
ARD1 9.1
DYRK1B 9.1
elongin C 9.1
ATP1 9.1
Sprouty 2 9.1
pyrroline-5-carboxylate reductase 9.0
USP13 9.0
lysyl oxidase 9.0
cytochrome P450c 9.0
JKTBP1 8.9
HIF3A 8.9
PFKFB4 8.9
ZIP13 8.9
cystine/glutamate transporter 8.9
LIMD1 8.8
PPARGC1B 8.8
MINT2 8.8
phosphoglycerate mutase 1 8.8
AQR 8.7
HSP47 8.7
tropomyosin 3 8.7
matrix metalloproteinase 10 8.7
CUL2 8.7
PSA1 8.7
Enh 8.7
Nip3 8.7
TTBK2 8.6
protein disulfide isomerase 8.6
phosphoserine phosphatase 8.6
FKBP65 8.6
HIF-2 alpha 8.5
CRTAP 8.5
eIF4GII 8.5
GLR 8.5
nidogen-2 8.5
lysyl oxidase-like 2 8.5
EPO protein 8.5
USP4 8.4
more...
Disease
Cardiac cirrhosis 12.1
FIH 11.2
Renal anemia 10.6
EDS VI 10.3
Hereditary Leiomyomatosis and Renal Cell Cancer 9.2
IBD5 9.0
Hippel 8.9
Glycerol kinase deficiency 8.6
pancreatic fibrosis 8.5
erythrocytosis 8.4
High myopia 8.2
chronic brain syndrome 8.1
Posterior capsule opacification 7.5
somatostatinoma 7.5
disorders of iron metabolism 7.5
Acute pyelonephritis 7.4
cancer angiogenesis 7.0
Transient ischemia 6.9
polycythemia 6.9
Carotid body 6.8
Carotid body 6.8
Carotid body 6.8
nasopharyngitis 6.8
hepatic neoplasm 6.7
scurvy 6.7
Schistosoma haematobium infection 6.4
vitamin C deficiency 6.4
Renovascular hypertension 6.3
vitamin B6 deficiency 6.3
normocytic anemia 6.2
CPX 6.1
pulmonary fibrosis 6.1
LAD2 6.0
chronic persistent hepatitis 6.0
liver fibrosis 6.0
Interstitial fibrosis 5.9
Cancer cachexia 5.9
hormone refractory prostate cancer 5.8
Meningioma 5.8
Meningioma 5.8
ochronosis 5.8
XPB 5.7
ST8 5.7
trophoblastic tumor 5.7
alcoholic hepatitis 5.6
myotonia congenita 5.6
Cirrhosis 5.6
hyperviscosity syndrome 5.6
EBM 5.6
DBM 5.5
SMC 5.5
Ehlers-Danlos syndrome 5.5
Chronic kidney disease (CKD) 5.4
PDC 5.4
Renal fibrosis 5.4
paraganglioma 5.4
biliary atresia 5.3
Alkaptonuria 5.3
Morquio 5.3
Pulmonary arterial hypertension 5.3
collagen disease 5.2
disc degeneration 5.2
anemia 5.2
degenerative disc disease 5.2
endomyocardial fibrosis 5.2
mountain sickness 5.1
SLS 5.1
fibrocystic disease 5.1
PARK2 5.1
cholesterolemia 5.1
Menkes 5.1
SLS 5.0
collagen disease 5.0
chronic active hepatitis 5.0
seborrheic keratosis 5.0
retinopathy of prematurity 5.0
AAT deficiency 4.9
tumor angiogenesis 4.9
bronchopulmonary dysplasia 4.7
Ischemic stroke 4.7
cutis laxa 4.7
lymphogranuloma venereum 4.6
iron deficiency 4.6
phyllodes tumor 4.6
pseudoxanthoma elasticum 4.5
Rous sarcoma 4.5
tumor vasculature 4.5
familial cancer 4.5
nephrosclerosis 4.4
Schistosoma mansoni infection 4.4
acute hepatitis 4.3
Hypertrophic 4.3
cirrhosis 4.3
osteogenesis imperfecta 4.2
hemangioblastoma 4.2
Autosomal dominant polycystic kidney disease 4.2
xanthoma 4.2
scleroderma 4.2
hypertrichosis 4.2
PTP 4.1
Bowen's disease 4.1
Toxic epidermal necrolysis 4.1
uterine cancer 4.1
proliferative vitreoretinopathy 4.0
cervical squamous cell carcinoma 4.0
chronic liver disease 4.0
arteriosclerosis 4.0
AGS 4.0
proliferative diabetic retinopathy 4.0
PER 3.9
PPP 3.9
LAP 3.9
CHS 3.9
primary biliary cirrhosis 3.9
retinopathy 3.8
Reiter's syndrome 3.8
iron overload 3.8
lichen sclerosus 3.8
renal ischemia 3.8
CNS diseases 3.8
pulmonary hypertension 3.7
glycogen storage disease 3.7
Esophageal squamous cell carcinoma 3.7
tumor progression 3.7
Pancreas 3.6
ischemia 3.6
chronic pancreatitis 3.6
Pancreas 3.6
renal cyst 3.5
monoclonal gammopathy of undetermined significance 3.5
adenocarcinoma of the lung 3.5
lymphangioleiomyomatosis 3.5
nephrosis 3.5
tumor growth 3.5
pheochromocytoma 3.4
filariasis 3.4
LAD 3.4
polymyositis 3.4
lichen planus 3.4
renal cancer 3.4
fibromatosis 3.4
chordoma 3.4
erythema nodosum 3.4
hemochromatosis 3.3
colitis 3.3
tumor initiation 3.3
Nasopharyngeal carcinoma 3.3
Plaque 3.3
tumorigenesis 3.3
Luminal 3.3
diabetic nephropathy 3.3
silicosis 3.3
skin tumor 3.2
Gilbert 3.2
cerebral ischemia 3.2
Dissociation 3.2
solid tumor 3.2
liver cancer 3.2
liver disease 3.2
gestational trophoblastic disease 3.1
more...
Symptom
Cold intolerance 8.0
dysesthesia 5.2
hyperesthesia 5.0
hyperoxia 4.8
fasciculation 3.8
twitching 3.1
polydipsia 3.0
starvation 2.8
cachexia 2.6
hypotonia 2.6
polyuria 2.5
respiratory distress 2.4
functional recovery 2.0
paresthesia 1.8
numbness 1.8
thinning 1.6
hypercapnia 1.1
hypothermia 1.0
splenomegaly 0.8
low back pain 0.8
back pain 0.5
dyspnea 0.3
acidity 0.2
tremor -0.1
nausea -0.4
collapse -0.7
diarrhea -0.7
abdominal pain -0.8
fatigue -1.6
pain -1.6
headache -1.7
anesthesia -2.7
Drug
Malotilate 10.9
Creosote 8.4
Silodosin 8.4
CoCl2 7.5
CoCl2 7.5
Dilantin 6.8
Deferasirox 6.5
Tranilast 6.4
Raltegravir 6.3
ascorbate 6.2
Desferal 6.1
Desferal 6.0
ID2 6.0
Piracetam 5.7
ATV 5.5
Rosiglitazone 5.4
Oxaliplatin 5.3
Metrizamide 4.9
Phenytoin 4.7
Gelfoam 4.6
OTC 4.6
Triclosan 4.5
Cetuximab 4.2
OTC 4.0
Serum albumin 3.8
Nitric Oxide 3.8
BLM 3.7
lysine 3.6
Asn 3.6
Prednisolone 3.6
balanced salt solution 3.5
Heme 3.5
TAC 3.4
Angiotensin II 3.4
Activin 3.4
Gelatin 3.3
Docetaxel 3.3
niacin 3.2
EPI 3.1
ACT 3.0
Silica 2.9
Gel 2.8
Alliance 2.7
Alanine 2.7
ADM 2.5
NADH 2.3
Glucagon 2.2
ROS 2.2
EE2 2.2
DNase I 2.1
Dial 2.0
Albumin 1.9
citric acid 1.8
G-CSF 1.7
ICI 1.7
CTX 1.6
CTX 1.6
CAM 1.6
CSF 1.5
CaCl2 1.5
CaCl2 1.5
CaCl2 1.4
PTH 1.4
MAP 1.2
ENT 1.0
ABC 1.0
nitroglycerin 1.0
Ethanol 0.8
CTX 0.8
ZnO 0.4
Dermatol 0.3
Cardiovasc -0.2
IFN-gamma -0.7
Enzyme
EC 1.14.11.12 14.1
prolyl hydroxylase 14.1
galactosylhydroxylysyl glucosyltransferase 13.1
prolyl 3-hydroxylase 12.9
lysyl hydroxylase 12.1
collagen galactosyltransferase 11.7
protein disulfide-isomerase 10.5
phosphopantothenoylcysteine synthetase 10.4
PHD 10.1
lysyl oxidase 9.1
deoxyhypusine hydroxylase 9.1
type III procollagen 9.1
phosphoserine phosphatase 8.6
3-hydroxyanthranilic acid oxygenase 8.1
calpain 10 8.1
proline oxidase 8.0
gamma-butyrobetaine hydroxylase 7.8
EC 2.6.1.16 7.6
3-dehydroquinate 7.3
AlkA 7.3
PPH 7.2
stromelysin-3 7.1
anthocyanidin synthase 6.9
flavonol synthase 6.9
glycogenin 6.9
deoxyhypusine synthase 6.8
oxoglutarate dehydrogenase 6.8
fumarase 6.8
violaxanthin de-epoxidase 6.6
homogentisate 1,2-dioxygenase 6.5
cinnamate 4-hydroxylase 6.4
uridine kinase 6.4
PDK1 6.3
cysteine dioxygenase 6.3
formaldehyde dehydrogenase 6.2
ornithine aminotransferase 6.2
sulfhydryl oxidase 6.2
ascorbate oxidase 6.1
dehydroascorbate reductase 6.0
meprin 6.0
biliverdin reductase 6.0
glycerophosphate acyltransferase 5.8
branching enzyme 5.8
UDP-glucose dehydrogenase 5.8
Lys4 5.7
nicotinamide phosphoribosyltransferase 5.6
collagenase 5.6
alpha-ketoglutarate dehydrogenase 5.4
caspase-7 5.3
caspase-7 5.3
AMP-activated kinase 5.2
interstitial collagenase 5.2
histone demethylase 5.2
caspase-6 5.2
prolidase 5.1
caspase-6 5.1
N-acetylglucosaminyltransferase 5.1
succinate dehydrogenase 5.1
thymidine phosphorylase 5.1
ADPase 5.0
isopeptidase 5.0
proteasome 4.9
pepsin 4.8
galactokinase 4.8
MPP 4.8
PDH 4.7
methionine adenosyltransferase 4.7
deoxycytidine kinase 4.6
glycerol kinase 4.6
ribonucleotide reductase 4.5
hexokinase 4.5
alcohol oxidase 4.5
FAST 4.5
matrix metalloproteinase 2 4.5
isocitrate dehydrogenase 4.5
peptidyl-prolyl cis-trans isomerase 4.5
TMT 4.5
TACE 4.5
acyl-CoA synthetase 4.4
heme oxygenase 4.4
phenol oxidase 4.4
ornithine transcarbamylase 4.4
isocitrate dehydrogenase 4.3
aconitase 4.3
acylase 4.3
gamma-glutamyl transpeptidase 4.3
enolase 4.2
firefly luciferase 4.2
ribonucleotide reductase 4.2
GAS 4.2
diacylglycerol kinase 4.2
BAL 4.2
calcium pump 4.1
ECH 4.1
PAL 4.0
NADH dehydrogenase 4.0
MMP-3 3.9
myosin ATPase 3.9
pyruvate dehydrogenase 3.9
pyruvate dehydrogenase 3.9
phosphatidylinositol 3-kinase 3.8
carbonic anhydrase 3.8
thymidine kinase 3.8
phosphofructokinase 3.8
acyl-CoA synthetase 3.8
transketolase 3.8
cathepsin D 3.7
phenylalanine hydroxylase 3.6
ascorbate peroxidase 3.6
MMP 3.6
transpeptidase 3.6
aldehyde dehydrogenase 3.6
aldehyde dehydrogenase 3.6
aldehyde dehydrogenase 3.6
citrate synthase 3.6
alpha-mannosidase 3.5
apyrase 3.5
Alternating 3.5
transglutaminase 3.4
AMP-activated protein kinase 3.4
aryl hydrocarbon hydroxylase 3.4
aldehyde dehydrogenase 3.4
aldolase 3.3
pyruvate kinase 3.3
glycerol-3-phosphate dehydrogenase 3.3
tryptophan hydroxylase 3.3
complex I 3.3
cathepsin G 3.3
glycerol-3-phosphate dehydrogenase 3.3
pyruvate dehydrogenase 3.3
MEKK1 3.2
glutaminase 3.2
beta-glucuronidase 3.2
luciferase 3.1
NADPH oxidase 3.1
cdc2 3.1
aldehyde dehydrogenase 3.0
glutamate dehydrogenase 3.0
glyceraldehyde-3-phosphate dehydrogenase 3.0
glutamate dehydrogenase 3.0
glyceraldehyde-3-phosphate dehydrogenase 3.0
cytochrome oxidase 3.0
matrix metalloproteinase 9 3.0
glutamate dehydrogenase 3.0
ADH 3.0
lactate dehydrogenase 3.0
NO synthase 3.0
NADPH oxidase 3.0
elastase 2.9
malate dehydrogenase 2.9
glyceraldehyde-3-phosphate dehydrogenase 2.9
IKK 2.8
MIP 2.8
diamine oxidase 2.8
PKG 2.8
alkaline phosphatase 2.8
ceruloplasmin 2.8
acid phosphatase 2.8
peroxiredoxin 2.7
alanine aminotransferase 2.7
more...
Compound
ethyl 3,4-dihydroxybenzoate 12.9
Coumalic acid 12.5
Glucosylgalactosylhydroxylysine 12.1
4-hydroxyproline 10.8
4-hydroxyproline 10.8
4-hydroxyproline 10.8
4-hydroxyproline 10.8
4-hydroxyproline 10.8
4-hydroxyproline 10.8
Bleomycin sulfate 10.5
Hydroxyproline 9.8
4-methylproline 9.5
Poly ICLC 9.5
Hydroxylysine 9.3
Pimonidazole 9.3
Pimonidazole 9.3
Mimosine 9.3
Pro-Gly 8.8
2-oxoglutarate 8.7
2-Oxoglutarate 8.5
Desmosine 8.4
Sodium hydrosulfide 8.3
hydroxyglutarate 8.1
protocatechuate 8.0
Dianabol 8.0
Deoxyribose 7.8
Z-Gly-Pro 7.8
Dihydralazine 7.8
Cys-Gly 7.8
Mimosine 7.8
Amentoflavone 7.7
ABPP 7.7
R 1881 7.6
Emetine 7.5
Acriflavine 7.5
4-oxobutanoic acid 7.5
Oil Red 7.4
Aloe-emodin 7.3
Reticulin 7.3
2-oxoadipate 7.3
HMBA 7.2
Retinyl palmitate 7.2
proline 7.2
Digitoxin 7.1
CPH 7.1
Collagen 7.1
Tin 7.0
Esculetin 6.9
DCVC 6.8
HMBA 6.8
TET 6.8
TET 6.8
Temsirolimus 6.7
DHB 6.6
DETA 6.6
2-methoxyethyl 6.6
2-methoxyethyl 6.6
C10H8N2 6.5
8-hydroxyguanosine 6.5
Hydralazine 6.4
Tetramethylpyrazine 6.4
Magnolol 6.4
8-quinolinol 6.4
Wogonin 6.4
4-phenylpyridine 6.3
Ascorbic acid 6.3
1,2,3,6-tetrahydropyridine 6.2
1,2,3,6-tetrahydropyridine 6.2
Caffeic acid phenethyl ester 6.2
Desferal 6.1
Azan 6.1
Ecdysone 6.1
[1,10]phenanthroline 6.1
DFO 6.1
Coenzyme A 6.0
CCl4 5.8
Proline 5.8
Rosmarinic acid 5.8
Rosmarinic acid 5.8
Vinca 5.7
Tiron 5.6
Ticlopidine 5.6
DBM 5.6
dicarboxylic acid 5.6
DBM 5.6
NMA 5.5
Agmatine 5.4
Keloid 5.4
Fumarate 5.4
succinic acid 5.3
Pyruvate kinase 5.3
prostaglandin J2 5.3
Flavin 5.3
Crystal Violet 5.2
D-glucosamine 5.1
DMN 5.1
Paraquat 5.1
FAP 5.1
FAP 5.1
MPT 5.1
Paraquat 5.0
BLM 5.0
MPP 4.9
PGJ2 4.9
MPP 4.9
alpha-Tocopherol 4.9
Isoform 4.9
carbonic acid 4.9
carbonic acid 4.9
carbonic acid 4.9
carbonic acid 4.9
carbonic acid 4.9
carbonic acid 4.9
carbonic acid 4.9
carbonic acid 4.9
carbonic acid 4.9
carbonic acid 4.9
carbonic acid 4.9
carbonic acid 4.9
carbonic acid 4.9
carbonic acid 4.9
carbonic acid 4.8
carbonic acid 4.8
carbonic acid 4.8
Hemin 4.8
Hemin 4.8
Hemin 4.8
Hemin 4.8
Tempol 4.8
carbonic acid 4.8
Quinone 4.6
Hemin 4.6
asparagine 4.6
NPPB 4.5
Poly I 4.5
DCA 4.5
Cobalt 4.5
DCA 4.5
MPC 4.5
BSO 4.5
Cycloheximide 4.5
PAG 4.5
TACE 4.4
Phosphatidylcholine 4.4
oxygen 4.4
iron 4.4
MAD 4.4
isocitrate 4.4
1H-imidazole 4.4
NiCl2 4.4
Polypeptide 4.4
Dexmedetomidine 4.3
carbonic acid 4.3
Suramin 4.3
Evans Blue 4.3
PAS 4.3
Trichloroethylene 4.3
naphthoquinone 4.3
naphthoquinone 4.3
naphthoquinone 4.3
more...