Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.14.11.2 (prolyl hydroxylase)
 1,814 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
collagen 562
prolyl 4-hydroxylase 447
PHD2 150
Mol 128
Sep 112
erythropoietin 109
vascular endothelial growth factor 106
Prolyl hydroxylase 103
HIF-1alpha 94
proline hydroxylase 84
HIF-1 84
polypeptide 79
endoplasmic reticulum 69
PHD3 67
lysyl hydroxylase 58
PHD1 56
PHD 54
proteasome 48
lysyl oxidase 42
collagenase 40
protein disulfide isomerase 37
hemoglobin 35
ubiquitin 34
type I collagen 30
VEGF 30
cytokine 28
pVHL 27
fibronectin 24
E3 ubiquitin ligase 23
ATP 23
HIF-1 alpha 22
ubiquitin ligase 22
p53 22
von Hippel-Lindau tumor suppressor 21
insulin 21
type I procollagen 20
VHL 20
alkaline phosphatase 19
disulfide isomerase 19
glucose transporter 19
HIF1 19
microsomal 19
mTOR 17
IL-6 17
SDS 17
histone 17
vimentin 17
p300 16
Skp1 16
Dictyostelium 15
matrix metalloproteinase 15
alpha-smooth muscle actin 15
ferritin 14
caspase-3 14
elastin 14
thyroid hormone 13
EGLN3 13
erythroid 13
superoxide dismutase 13
CD31 13
proline-rich 12
glycosyltransferase 12
microsomal triglyceride transfer protein 12
type II collagen 11
CD34 11
inducible nitric oxide synthase 11
Lysyl hydroxylase 11
ACS 11
Erythropoietin 11
MMP-2 11
MMP-9 11
transcriptional factor 10
PDI 10
membrane-bound 10
heme oxygenase-1 10
peroxidase 10
glutathione-insulin transhydrogenase 10
proteoglycan 10
CaSR 10
SCF 10
estrogen receptor 9
HIF-1beta 9
TNF 9
osteogenic 9
aggrecan 9
tumor necrosis factor 9
phosphatidylinositol 3-kinase 9
TGF-beta 9
nitric oxide synthase 9
IL-8 9
ODD 9
epidermal growth factor receptor 9
oxidoreductase 9
proteasome inhibitor 8
osteosarcoma 8
glycoprotein 8
beta polypeptide 8
lactate dehydrogenase 8
PI3K 8
Bcl-2 8
lipopolysaccharide 8
gut 8
metalloproteinase 7
Chlamydomonas 7
transferrin 7
ERK1 7
transcriptional activator 7
CD68 7
myeloperoxidase 7
glucosyltransferase 7
cytochrome c 7
HIF2A 7
Ki-67 7
EPO 7
MAPK 7
monocyte chemoattractant protein-1 7
hexokinase 7
smooth muscle actin 7
interferon 7
fumarate hydratase 6
Prolyl hydroxylase domain-containing protein 2 6
COL1A1 6
erythropoietin receptor 6
reductase 6
dimeric 6
C-terminal peptide 6
P4HA2 6
EDS VI 6
BNIP3 6
CO2 6
oxoglutarate 6
IL-4 6
MCP-1 6
vascular endothelium 6
myosin 6
connective tissue growth factor 6
basic helix-loop-helix 6
osteocalcin 6
thymidine kinase 6
phosphatase 6
P3H1 6
S100A4 6
P4HB 6
p38 6
galactosyltransferase 6
Pseudomonas 6
transcriptional regulator 6
AMP-activated protein kinase 6
vascular endothelial growth factor A 6
EGLN2 6
carbonic anhydrase 6
PDGF 6
tumour suppressor 6
NADH 6
platelet-derived growth factor 6
heat shock protein 6
FIH-1 6
ERK 6
pyruvate dehydrogenase kinase 6
tyrosine hydroxylase 5
more...
Disease
cancer 171
tumor 133
Hippel 120
anemia 109
ischemia 64
cirrhosis 46
tumor growth 37
stroke 34
tumorigenesis 32
tumor progression 30
hepatocellular carcinoma 30
liver fibrosis 30
breast cancer 28
pulmonary fibrosis 27
erythrocytosis 24
myocardial infarction 18
carcinoma 18
SDS 17
hypertension 16
diabetes 16
liver disease 16
pulmonary hypertension 14
atherosclerosis 14
hepatitis 12
polycythemia 12
melanoma 12
colitis 11
Alzheimer's disease 11
obesity 10
tumor angiogenesis 10
lung cancer 10
FIH 10
rheumatoid arthritis 10
renal cell carcinoma 10
myocardial ischemia 10
Parkinson's disease 10
iron deficiency 10
cold 10
cardiovascular disease 10
metastases 9
inflammatory bowel disease 9
glioma 9
carcinogenesis 9
cerebral ischemia 9
pheochromocytoma 9
osteosarcoma 8
retinopathy 8
prostate cancer 8
chronic liver disease 8
hyperglycemia 8
depression 8
paraganglioma 8
chronic active hepatitis 7
colon cancer 7
liver cancer 7
osteoarthritis 7
colorectal cancer 7
renal disease 7
pneumonia 7
pancreatic fibrosis 7
lung disease 7
worms 6
acute hepatitis 6
diabetic nephropathy 6
scleroderma 6
bronchopulmonary dysplasia 6
fatty liver 6
liver cancer 6
ulcerative colitis 5
lymphoma 5
Pancreas 5
adenocarcinoma 5
retinopathy of prematurity 5
iron overload 5
proteinuria 5
MCF 5
Ehlers-Danlos syndrome 5
biliary atresia 5
arteriosclerosis 5
uterus 5
neuroblastoma 5
chronic pancreatitis 5
chronic obstructive pulmonary disease 5
cystic fibrosis 5
gastric cancer 5
Pancreas 5
EDS VI 4
infectious diseases 4
Rous sarcoma 4
chronic persistent hepatitis 4
pancreatic cancer 4
disc degeneration 4
hepatitis B 4
alcoholic hepatitis 4
pulmonary edema 4
psoriasis 4
primary biliary cirrhosis 4
Renal anemia 4
type 2 diabetes 4
osteoporosis 4
blindness 4
cataract 4
Chronic kidney disease (CKD) 4
sepsis 4
ovarian cancer 4
scurvy 4
sarcoma 4
schistosomiasis 4
arthritis 4
solid tumor 4
sepsis 4
Crohn's disease 4
periodontitis 3
peripheral neuropathy 3
fibrosarcoma 3
sickle cell disease 3
leukemia 3
chronic hepatitis 3
pancreatitis 3
Infection 3
acute myocardial infarction 3
irritable bowel syndrome 3
emphysema 3
diabetic retinopathy 3
hepatitis C 3
cholestasis 3
myopathy 3
muscular atrophy 3
renal cancer 3
heart failure 3
multiple myeloma 3
viral hepatitis 3
osteogenesis imperfecta 3
tumor vasculature 3
SMC 3
vascular disease 3
glioblastoma 3
lung carcinoma 3
acute pancreatitis 3
Pulmonary arterial hypertension 3
AIDS 3
wasting 3
non-small cell lung cancer 3
mole 3
suicide 3
cornea 3
Cirrhosis 3
HIV 3
vitamin C deficiency 3
retinitis pigmentosa 2
Schistosoma mansoni 2
retinoblastoma 2
proliferative diabetic retinopathy 2
lung metastases 2
filariasis 2
brain tumor 2
polycystic kidney 2
epilepsy 2
astrocytoma 2
nasopharyngitis 2
more...
Symptom
starvation 10
hyperoxia 8
respiratory distress 6
pain 5
functional recovery 3
dyspnea 2
dysesthesia 2
hypothermia 2
hypotonia 2
thinning 2
diarrhea 2
cachexia 2
Cold intolerance 1
fatigue 1
polydipsia 1
numbness 1
anesthesia 1
nausea 1
back pain 1
splenomegaly 1
acidity 1
tremor 1
abdominal pain 1
hypercapnia 1
low back pain 1
paresthesia 1
twitching 1
collapse 1
polyuria 1
headache 1
hyperesthesia 1
fasciculation 1
Drug
ascorbate 94
lysine 41
Dermatol 18
CoCl2 13
CoCl2 13
Cardiovasc 10
Asn 8
Dial 7
NADH 6
Gel 6
CSF 5
ROS 5
Malotilate 3
Angiotensin II 3
citric acid 2
EE2 2
Rosiglitazone 2
Heme 2
Nitric Oxide 2
MAP 2
Triclosan 2
niacin 2
Oxaliplatin 2
DNase I 2
Phenytoin 2
ATV 1
Tranilast 1
nitroglycerin 1
CTX 1
Gelfoam 1
OTC 1
Desferal 1
CaCl2 1
Serum albumin 1
Glucagon 1
CAM 1
BLM 1
ABC 1
OTC 1
EPI 1
CaCl2 1
Docetaxel 1
Silodosin 1
Desferal 1
CTX 1
CTX 1
Cetuximab 1
ACT 1
Alanine 1
IFN-gamma 1
Raltegravir 1
Metrizamide 1
Piracetam 1
ADM 1
Creosote 1
Prednisolone 1
Alliance 1
balanced salt solution 1
Activin 1
Gelatin 1
G-CSF 1
ICI 1
PTH 1
TAC 1
Deferasirox 1
ENT 1
Dilantin 1
Albumin 1
Ethanol 1
CaCl2 1
ID2 1
ZnO 1
Silica 1
Enzyme
prolyl hydroxylase 1814
lysyl hydroxylase 62
PHD 54
proteasome 49
collagenase 49
galactosylhydroxylysyl glucosyltransferase 42
lysyl oxidase 40
ERK 25
type III procollagen 21
alkaline phosphatase 19
luciferase 19
mitogen-activated protein kinase 19
superoxide dismutase 17
peroxidase 16
succinate dehydrogenase 16
pepsin 14
protein disulfide-isomerase 13
lactate dehydrogenase 13
trypsin 13
caspase-3 12
prolyl 3-hydroxylase 11
ACS 11
gamma-glutamyl transpeptidase 10
protein kinase 10
alanine aminotransferase 10
PDK1 10
phosphatidylinositol 3-kinase 9
AMP-activated protein kinase 8
protein kinase C 8
NO synthase 7
hexokinase 7
fumarase 7
focal adhesion kinase 6
aspartate aminotransferase 6
carbonic anhydrase 6
thymidine kinase 6
creatine kinase 6
catalase 5
acid phosphatase 5
complex I 5
heme oxygenase 5
NADPH oxidase 5
NADPH oxidase 5
tyrosine hydroxylase 5
elastase 4
proline oxidase 4
glutathione S-transferase 4
cytochrome oxidase 4
chymotrypsin 4
collagen galactosyltransferase 4
ribonucleotide reductase 4
isocitrate dehydrogenase 4
cdc2 4
phospholipase C 4
enolase 4
beta-glucuronidase 4
isocitrate dehydrogenase 4
phosphoserine phosphatase 3
RNA polymerase 3
MMP 3
pyruvate dehydrogenase 3
tyrosinase 3
aldehyde dehydrogenase 3
MPP 3
ascorbate oxidase 3
aldehyde dehydrogenase 3
aldehyde dehydrogenase 3
aldehyde dehydrogenase 3
phosphofructokinase 3
aldehyde dehydrogenase 3
firefly luciferase 3
pyruvate dehydrogenase 3
citrate synthase 3
matrix metalloproteinase 2 3
RNase 3
MMP-3 3
cathepsin D 3
transglutaminase 3
pyruvate kinase 3
pyruvate dehydrogenase 3
calcineurin 3
ornithine aminotransferase 3
alpha-ketoglutarate dehydrogenase 3
ribonucleotide reductase 3
glutamate dehydrogenase 2
PPH 2
thymidine phosphorylase 2
glutamate dehydrogenase 2
IKK 2
reverse transcriptase 2
ATPase 2
AMPK 2
BAL 2
PAL 2
aconitase 2
caspase-7 2
caspase-9 2
interstitial collagenase 2
caspase-7 2
glucose oxidase 2
glyceraldehyde-3-phosphate dehydrogenase 2
MIP 2
aldolase 2
GSK 2
glyceraldehyde-3-phosphate dehydrogenase 2
AMPK 2
glyceraldehyde-3-phosphate dehydrogenase 2
dehydroascorbate reductase 2
MAP 2
RNase 2
glyceraldehyde-3-phosphate dehydrogenase 2
EC 1.14.11.12 2
APC 2
meprin 2
lipase 2
ceruloplasmin 2
ascorbate peroxidase 2
ornithine transcarbamylase 2
deoxyhypusine hydroxylase 2
histone demethylase 2
NADH dehydrogenase 2
malate dehydrogenase 2
diaphorase 2
AST 2
renin 2
guanylate cyclase 2
glyceraldehyde-3-phosphate dehydrogenase 2
beta-galactosidase 2
branching enzyme 2
glutamate dehydrogenase 2
acyl-CoA synthetase 1
PARP 1
aldose reductase 1
GAS 1
stromelysin-3 1
glutaminase 1
glycerophosphate acyltransferase 1
UDP-glucose dehydrogenase 1
topoisomerase 1
kallikrein 1
3-dehydroquinate 1
monoamine oxidase 1
transcriptase 1
PDH 1
ACE 1
topoisomerase 1
diamine oxidase 1
ADH 1
DNA polymerase 1
apyrase 1
PKG 1
caspase-6 1
uridine kinase 1
homogentisate 1,2-dioxygenase 1
ADPase 1
phosphoinositide 3-kinase 1
prolidase 1
ATP synthase 1
glycogenin 1
caspase-6 1
more...
Compound
oxygen 446
proline 260
2-oxoglutarate 178
iron 167
Dec 132
DNA 107
Collagen 69
glucose 66
Clin 64
Hydroxyproline 57
lysine 52
4-hydroxyproline 44
4-hydroxyproline 44
4-hydroxyproline 44
4-hydroxyproline 44
4-hydroxyproline 44
4-hydroxyproline 44
Pro-Gly 34
Ascorbic acid 26
pyridine 26
cobalt 25
ATP 23
calcium 23
nitric oxide 22
water 22
alanine 20
phosphate 19
leucine 19
cysteine 19
arginine 18
SDS 18
salt 18
sodium 18
Gly 18
protocatechuate 17
asparagine 17
sulfate 17
zinc 17
CCl4 16
hydroxyglutarate 15
His 15
ethanol 14
acetate 13
dicarboxylic acid 13
galactose 11
CO2 11
PEG 11
ACS 11
ACS 11
threonine 11
copper 10
Triton X-100 10
tyrosine 10
bromide 10
TNF 9
hydrogen 9
Asp 9
H2O2 8
nickel 8
succinic acid 8
urea 8
glutamine 8
Cardiol 8
cadmium 7
cAMP 7
manganese 7
Dial 7
Tin 7
PAS 7
nitrogen 7
NADH 6
NAD 6
Cys-Gly 6
MTT 6
GlcNAc 6
ethyl 3,4-dihydroxybenzoate 6
glutamate 6
DEAE 6
Phe 6
creatinine 6
Proline 6
serine 6
BLM 5
DFO 5
retinoic acid 5
acetic acid 5
AMP 5
NH2 4
ammonium 4
TOF 4
nicotinamide 4
ADP 4
NAD 4
TEM 4
acrylamide 4
TET 4
methionine 4
Off 4
TCA 4
TET 4
hyaluronic acid 4
ADP 3
2-Oxoglutarate 3
THP 3
CoA 3
Mimosine 3
Resveratrol 3
MDA 3
pentose 3
cGMP 3
pentose 3
naphthoquinone 3
Neuronal 3
naphthoquinone 3
pentose 3
pyrimidine 3
naphthoquinone 3
ADP 3
Cycloheximide 3
ADR 3
Hydralazine 3
D-glucosamine 3
MPP 3
silicon 3
potassium 3
THP 3
HCl 3
naphthoquinone 3
N-acetylcysteine 3
boron 3
Adriamycin 3
naphthoquinone 3
Angiotensin II 3
DETA 3
cyanide 3
naphthoquinone 3
pyrimidine 3
Cobalt 3
naphthoquinone 3
oxalate 3
C-3 3
pentose 3
MPP 3
COS 3
Mg2+ 3
dUTP 3
GTP 3
succinic acid 2
superoxide radical 2
benzoic acid 2
COX 2
FAP 2
Pimonidazole 2
FAP 2
Hydroxylysine 2
Ile 2
NADP 2
Quercetin 2
uridine 2
acridine 2
more...