Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.13.12.5 (
aequorin
)
1,451
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The
LPA
(2) protein is overexpressed in many tumor cells. We report the optimization of a series of
LPA
(2) antagonists using calcium mobilization assay (
aequorin
assay) that led to the discovery of the first reported inhibitors selective for
LPA
(2). Key compounds were evaluated in vitro for inhibition of
LPA
(2) mediated Erk activation and proliferation of HCT-116 cells. These compounds could be used to evaluate the benefits of
LPA
(2) inhibition both in vitro and in vivo.
...
PMID:Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents. 1817 86
