EC:1.13.11.12 - FACTA Search

Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Target Concepts:

Query: EC:1.13.11.12 (lipoxygenase)
8,696 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)

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Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein
lipoxygenase	8604
cyclooxygenase	2678
Sep	636
5-lipoxygenase	621
phospholipase A2	537
Mol	316
15-lipoxygenase	299
catalase	254
superoxide dismutase	244
12-lipoxygenase	237
LOX	233
peroxidase	209
cytochrome P450	203
COX-2	179
phospholipase	171
thrombin	150
cytochrome P-450	140
NMR	136
collagen	133
FPL	127
lipopolysaccharide	124
cytokine	121
xanthine oxidase	121
ATP	114
insulin	112
cyclooxygenase-2	111
bradykinin	110
COX-1	109
PGD2	106
microsomal	104
nitric oxide synthase	103
GSH	103
PAF	92
15-LOX	91
glutathione peroxidase	91
lipase	89
12-LOX	88
TNF	85
AMP	82
albumin	80

Disease
cancer	388
tumor	327
atherosclerosis	167
asthma	153
carcinogenesis	128
ischemia	108
GSH	103
PAF	92
hypertension	91
diabetes	81
anaphylaxis	76
pertussis	68
SRS	64
cold	61
arthritis	55
psoriasis	53
leukemia	52
tumorigenesis	46
carcinoma	45
HHT	44
prostate cancer	44
Alzheimer's disease	43
cornea	40
tumor growth	40
breast cancer	40
rheumatoid arthritis	39
pulmonary edema	38
SDS	38
depression	37
stroke	36
metastases	34
glioma	32
SEM	32
uterus	31
colon cancer	31
adenocarcinoma	30
NAME	30
pulmonary hypertension	30
melanoma	29
inflammatory bowel disease	29

Symptom
pain	87
seizures	18
acidity	16
diarrhea	15
erythema	14
collapse	10
analgesia	10
spasm	10
respiratory distress	8
starvation	6
hyperoxia	5
anesthesia	5
chills	5
cachexia	5
anorexia	4
skin irritation	4
cough	4
nausea	4
tremor	4
functional recovery	4
tachypnea	3
exhaustion	3
bitter taste	3
hypercapnia	3
Anoxia	2
vomiting	2
sleepiness	2
Blanching	2
dry eye	2
angina	2
wheezing	2
dyspnea	2
hypothermia	2
Welt	2
tinnitus	2
colic	2
discomfort	2
scaly skin	2
headache	2
acute pain	2

Drug
Indomethacin	276
ascorbate	94
vitamin E	85
Dermatol	69
ROS	45
Histamine	37
Cardiovasc	36
EPA	34
NADH	33
lysine	27
IFN-gamma	22
ICI	21
CSF	20
IL-2	20
Leaf	18
linolenate	18
CaCl2	17
CaCl2	16
Vitamin E	16
CaCl2	16
MAP	15
Ethanol	15
caffeine	13
Angiotensin II	12
Zileuton	11
ALA	10
Glutathione	10
Nephron	10
Asn	8
Methylene blue	7
Gel	7
FLM	7
Tepoxalin	7
Asthma	7
Albumin	7
MRC	7
nitroglycerin	7
Capsicum	6
Piriprost	6
Atropine	6

Enzyme
lipoxygenase	8696
phospholipase A2	658
15-lipoxygenase	304
peroxidase	302
protein kinase C	276
superoxide dismutase	266
catalase	260
12-lipoxygenase	258
thrombin	148
phospholipase C	136
xanthine oxidase	117
mitogen-activated protein kinase	98
glutathione peroxidase	94
lipase	90
protein kinase	86
ascorbate peroxidase	76
tyrosinase	67
guanylate cyclase	67
trypsin	63
acetylcholinesterase	62
prostaglandin synthetase	61
glutathione reductase	58
ATPase	54
glutathione S-transferase	51
NADPH oxidase	51
soluble epoxide hydrolase	48
PAL	46
cholinesterase	46
NADPH oxidase	46
ornithine decarboxylase	38
adenylate cyclase	37
alcohol dehydrogenase	36
phospholipase D	35
NO synthase	34
lactate dehydrogenase	33
caspase-3	31
phosphodiesterase	30
renin	30
ERK	29
arachidonate 5-lipoxygenase	27

Compound
calcium	934
oxygen	765
Dec	628
PGE2	406
Arachidonic acid	398
Nordihydroguaiaretic acid	336
hydrogen	335
prostacyclin	317
sodium	306
water	303
acetate	287
iron	283
Indomethacin	276
DNA	267
Clin	265
LTC4	263
5-HETE	221
nitric oxide	219
12-hydroxyeicosatetraenoic acid	179
H2O2	148
Phe	144
glucose	139
bromide	138
arginine	122
cAMP	121
ATP	115
PGE	113
GSH	110
PGD2	110
GSH	110
ethanol	108
methanol	106
ASA	105
phosphate	100
salicylic acid	99
ADP	98
potassium	98
copper	96
Gly	96
LTE4	87