Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.12.7.2 (hydrogenase)
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Human Gene/Protein
NARF 10.8
selenophosphate synthase 10.8
HYD1 10.4
HYPC 10.3
H16 10.1
L-alanine:glyoxylate aminotransferase 10.0
ion transporter protein 10.0
integral membrane protein 2A 9.8
CALS 9.7
PSST subunit 9.6
20-alpha-hydroxysteroid dehydrogenase 9.6
IOP1 9.6
BBS 9.5
TYKY subunit 9.4
DC12 9.3
ISP2 9.3
DRAL 9.1
succinyl coenzyme A synthetase 9.1
CA11 9.0
FDH 8.9
TYKY 8.8
ferredoxin 8.8
DBP1 8.8
NCYM 8.7
ACSA 8.7
HUP1 8.6
MXD1 8.6
DHTKD1 8.6
glucose-6-phosphate 1-dehydrogenase 8.5
PSST 8.5
RNF 8.5
beta-ETF 8.1
Hos 8.1
TPAP 8.1
short-chain acyl-CoA dehydrogenase 8.1
Diaphorase 7.9
G20 7.9
cycA 7.9
DLST 7.9
NADH diaphorase 7.7
HYPA 7.7
electron transfer flavoprotein-ubiquinone oxidoreductase 7.7
NifU 7.6
nrf 7.6
Chlamydomonas 7.6
SDH2 7.5
complex I) 7.5
Succinic semialdehyde dehydrogenase 7.5
Acetyl-CoA synthetase 7.4
cytochrome b561 7.4
acylphosphatase 7.4
K72 7.4
NMI 7.3
NeuroD2 7.3
Oxidoreductase 7.3
FMN 7.3
component D 7.3
oxidoreductase 7.2
HP3 7.2
ACAA 7.2
ETF 7.2
CA6 7.1
MR-1 7.1
DNA directed 7.0
TUTase 7.0
nicotinamide nucleotide transhydrogenase 7.0
EPR 7.0
FADH2 7.0
IscU 6.9
DG2 6.9
TR-1 6.9
C2H2 6.9
diaphorase 6.9
HADH 6.9
CALU 6.9
FHL-1 6.9
PCC 6.8
NADH: ubiquinone oxidoreductase 6.8
KH1 6.8
ECE 6.7
more...
Disease
Ogo 11.1
HYD2 10.1
FDH 7.8
Bardet-Biedl syndrome 7.7
adaptation reaction 7.3
Benson 7.2
Other variants 6.8
Hodgson 6.7
PCC 6.6
NBS 6.6
familial hemophagocytic lymphohistiocytosis 6.4
Photosensitization 6.0
VPI 5.9
BCD 5.3
pheochromocytoma 5.3
SME 5.1
emerging infectious disease 5.0
SRS 5.0
SCH 4.9
Diffuse idiopathic skeletal hyperostosis 4.8
CAA 4.8
Vogt 4.7
MBS 4.6
Frey 4.6
DMC 4.6
complicated pregnancy 4.5
NHC 4.5
PMS 4.5
Brucella suis 4.5
Lowe 4.5
trichomoniasis 4.4
CAA 4.4
HP1 4.2
DES 4.2
RHE 4.0
MTC 4.0
Bradley 3.9
MCD 3.9
anemia of chronic disease 3.8
primary hyperoxaluria 3.7
RP4 3.7
APL 3.6
mole 3.5
APL 3.5
DIP 3.5
TCC 3.4
parakeratosis 3.4
NS2 3.4
HCI 3.4
SCS 3.3
pseudohypoparathyroidism 3.3
mole 3.3
Klebsiella 3.2
premenstrual syndrome 3.2
Proteus 3.1
conversion reaction 3.1
hereditary spherocytosis 3.0
bends 2.9
Dissociation 2.8
SDS 2.8
canker 2.8
chronic glomerulonephritis 2.7
APL 2.7
chemical carcinogenesis 2.7
CDS 2.7
Fox 2.6
typhoid 2.6
PGA 2.5
Tay-Sachs disease 2.5
hypernatremia 2.5
salmonellosis 2.4
hyperlipoproteinemia 2.4
Fibrillation 2.4
PAM 2.3
hypersensitivity pneumonitis 2.3
atherosclerotic cardiovascular disease 2.2
mimicry 2.2
Jensen 2.2
Giant 2.2
polyarteritis nodosa 2.2
more...
Symptom
starvation 2.1
flushing 2.1
acidity 1.6
exertional dyspnea 1.4
tremor -0.0
agitation -0.4
exhaustion -0.6
collapse -0.7
diarrhea -1.1
vomiting -1.8
anesthesia -3.6
Drug
Ferric oxide 9.1
Flavin 7.3
NADH 6.1
Chlorate 6.0
DMAP 5.8
FAD 5.8
Ethane 5.4
Olmesartan 5.4
Sandostatin 4.9
Sandostatin 4.9
PCB 4.6
MTC 4.2
THF 4.2
Sinemet 4.1
Metrizamide 3.9
CPM 3.9
CoCl2 3.9
CoCl2 3.9
ZnCl2 3.8
ZnCl2 3.8
Glycerol 3.6
CIA 3.5
ascorbate 3.4
Fructose 3.2
MOF 3.2
L-tyrosine 2.9
Vitamin B12 2.9
Arsenic trioxide 2.8
FeCl3 2.7
ALA 2.7
NH3 2.7
Glycyrrhiza 2.7
Gel 2.6
MgSO4 2.6
Heme 2.5
TiO2 2.5
Itraconazole 2.2
-deoxyadenosine 2.1
ABC 2.0
lysine 2.0
Fragment 2.0
TAT 1.9
Albumin 1.9
Glutathione 1.7
PCP 1.3
Ethanol 0.9
MAP 0.8
ROS 0.5
ZnO 0.4
DNase I 0.1
lactose 0.1
ampicillin 0.1
nitroglycerin 0.0
citric acid -0.1
Asn -0.4
Leaf -1.3
Enzyme
hydrogenase maturation endopeptidase 13.1
EC 1.12.2.1 13.1
hydrogenase 13.1
hydrogenase 13.1
bidirectional hydrogenase 13.1
membrane-bound hydrogenase 12.5
F420-reducing hydrogenase 12.1
methylenediurease 12.1
sulfur reductase 12.0
H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase 11.9
heterodisulfide reductase 11.6
methylenetetrahydromethanopterin dehydrogenase 11.0
sulfane sulfurtransferase 10.8
methylviologen-reducing hydrogenase 10.8
phloroglucinol reductase 10.8
pyruvate:ferredoxin oxidoreductase 10.7
CO dehydrogenase 10.7
EC 1.2.99.2 10.6
selenophosphate synthase 10.6
formate dehydrogenase 10.5
formate dehydrogenase 10.5
formate dehydrogenase 10.5
D-malate dehydrogenase 10.0
lactate racemase 9.9
formylmethanofuran dehydrogenase 9.6
butyrate kinase 9.6
butyryl-CoA dehydrogenase 9.5
decarbonylase 9.4
hydroxylamine reductase 9.1
glutaconyl-CoA decarboxylase 9.1
opine dehydrogenase 9.1
hydroxylamine reductase 9.1
nitrogenase 9.0
dissimilatory sulfite reductase 9.0
methyl coenzyme M reductase 8.9
nicotinic acid hydroxylase 8.9
isobutyryl-CoA mutase 8.8
malyl-CoA lyase 8.8
acetoacetate decarboxylase 8.7
KGOR 8.7
acetate kinase 8.6
fumarate reductase 8.6
superoxide reductase 8.5
glycine reductase 8.5
dihydroxyacetone kinase 8.5
methylglyoxal synthase 8.4
acetylene hydratase 8.4
pyruvate formate-lyase 8.4
cellodextrin phosphorylase 8.4
chlorate reductase 8.3
sulfite reductase 8.2
sulfite reductase 8.2
A-transferase 8.2
1,3-propanediol dehydrogenase 8.2
sulfite reductase 8.2
rubredoxin reductase 8.2
benzoyl-CoA reductase 8.1
enoate reductase 8.0
homocitrate synthase 8.0
coproporphyrinogen III oxidase 8.0
TSR 8.0
MT 1 7.9
phosphotransbutyrylase 7.7
glycerol dehydratase 7.5
biotin synthase 7.5
desulfhydrase 7.5
lysine 2,3-aminomutase 7.4
TUT 7.4
APS reductase 7.4
3-hydroxybutyryl-CoA dehydrogenase 7.4
ferredoxin reductase 7.4
glycolate dehydrogenase 7.3
acylphosphatase 7.3
isopropylmalate isomerase 7.2
cellobiose phosphorylase 7.2
succinic dehydrogenase 7.2
bilirubin oxidase 7.1
acetyl-CoA synthetase 6.9
glycerol dehydrogenase 6.9
EC 4.4.1.5 6.9
more...
Compound
Sirohydrochlorin 12.1
2-Hydroxyphenazine 12.1
2-Hydroxyphenazine 12.1
Benzyl Viologen 11.2
Coenzyme F420 10.9
C12H10O2 10.8
1,4-dichloro-2-butyne 10.6
2,3-bis(bromomethyl)quinoxaline 10.6
1,4-dichloro-2-butyne 10.6
H4MPT 10.4
Methanofuran 10.1
6-aminonicotinic acid 10.1
6-aminonicotinic acid 10.1
Curacin A 9.8
4-hydroxyphenyl acetate 9.4
Tetrahydrocortisol 9.4
Obacunone 9.3
2,4-DA 9.1
Salicylaldoxime 9.1
NPOH 9.1
Ferredoxin 8.9
1,2,3,4-tetrachlorobenzene 8.8
2-methyl-2-butenoic acid 8.7
CoM 8.7
Fe(CN)3 8.6
6-mercaptohexanoic acid 8.5
3-hydroxybutyryl-CoA 8.5
4-APP 8.4
Formate 8.4
malyl-CoA 8.3
DTMA 8.3
MBH 8.3
Fumarate 8.1
Plastoquinone 8.1
MPT 7.9
2-pyridinol 7.9
2-pyridinol 7.9
2-pyridinol 7.8
5-aminovalerate 7.8
butyryl-CoA 7.6
Helenalin 7.6
diphenylsilane 7.4
diphenylsilane 7.4
1,2,3-trichlorobenzene 7.4
3,4-dihydroisoquinoline 7.4
1-phenyl-1,2-ethanediol 7.3
G20 7.3
Mesna 7.2
C2H2 7.1
nickel 6.9
FMN 6.9
Flavin 6.9
pentadecane 6.8
XTP 6.8
DCMU 6.8
NiCl2 6.7
1,2-dithiolane 6.7
heptyl 6.6
heptyl 6.6
2-methyl-2,4-pentanediol 6.5
corrin 6.5
BTL 6.5
Copper sulfate 6.4
NAD 6.4
2-oxoadipate 6.4
SDZ PSC 833 6.3
2-butenal 6.3
NADP 6.3
Glycolate 6.3
cholan-24-oic acid 6.3
2,3-dihydrofuran 6.3
Chlorate 6.2
NAD 6.2
cholan-24-oic acid 6.2
Selenocysteine 6.2
NADH 6.1
Farnesyl diphosphate 6.1
1,2-dichloropropane 6.1
Menaquinone 6.0
MoO4 6.0
more...