Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.12.7.2 (
hydrogenase
)
3,522
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The butyrate analogue 2-bromobutyrate is toxic toward Clostridium acetobutylicum. After mutation using nitrosoguanidine, mutants resistant to the suicide co-substrate 2-bromobutyrate were selected. Such mutants no longer produced acetone, whereas the synthesis of butanol and ethanol was unaffected. Enzymatic analysis of a 2-bromobutyrate-resistant mutant showed a low level of coenzyme
A transferase
and of acetoacetate decarboxylase, the two enzymes implicated in the biosynthesis of acetone, whereas the level of
hydrogenase
was unaffected.
...
PMID:[Selection of mutants of Clostridium acetobutylicum defective in production of acetone]. 362 Feb 1
