Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.12.7.2 (
hydrogenase
)
3,522
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Rhizobitoxine produced by Bradyrhizobium species strongly prevented derepression of
hydrogenase
expression in free-living Bradyrhizobium japonicum, although the toxin had no effect on the activity of cells which had already synthesized
hydrogenase
protein. Dihydrorhizobitoxine, a structural analog of rhizobitoxine, proved to be a less potent inhibitor of
hydrogenase
derepression. Rhizobitoxine did not cause cell death at a concentration sufficient to eliminate
hydrogenase
expression. The large subunit of
hydrogenase
was not detectable with antibody after derepression in the presence of rhizobitoxine. The general pattern of proteins synthesized from 14C-labeled amino acids during derepression was not significantly different in the presence or absence of rhizobitoxine. These results indicated that rhizobitoxine inhibited
hydrogenase
synthesis in free-living B. japonicum.
Cystathionine
and methionine strongly prevented the inhibition of
hydrogenase
derepression by rhizobitoxine, suggesting that the inhibition involves the level of sulfur-containing amino acids in the cell.
...
PMID:Rhizobitoxine inhibition of hydrogenase synthesis in free-living Bradyrhizobium japonicum. 219 62
