Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.12.7.2 (
hydrogenase
)
3,522
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Oxidation of hydrogen (H
2
) to protons and electrons for energy production in fuel cells is currently catalyzed by platinum, but its low abundance and high cost present drawbacks to widespread adoption. Precisely controlled proton removal from the active site is critical in
hydrogenase
enzymes in nature that catalyze H
2
oxidation using earth-abundant metals (iron and nickel). Here we report a synthetic iron complex, (Cp
C
5
F
4
N
)Fe(P
Et
N
(CH
2
)
3
NMe
2
P
Et
)(Cl), that serves as a precatalyst for the oxidation of H
2
, with turnover frequencies of 290 s
-1
in
fluorobenzene
, under 1 atm of H
2
using 1,4-diazabicyclo[2.2.2]octane (DABCO) as the exogenous base. The inclusion of a properly tuned outer coordination sphere proton relay results in a cooperative effect between the primary, secondary and outer coordination spheres for moving protons, increasing the rate of H
2
oxidation without increasing the overpotential when compared with the analogous complex featuring a single pendant base. This finding emphasizes the key role of pendant amines in mimicking the functionality of the proton pathway in the
hydrogenase
enzymes.
...
PMID:Increasing the rate of hydrogen oxidation without increasing the overpotential: a bio-inspired iron molecular electrocatalyst with an outer coordination sphere proton relay. 2914 78
