Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.11.1.9 (
glutathione peroxidase
)
22,002
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Apomorphine hydrochloride
(
APO
) is known to be a dopamine receptor agonist, and has recently been found to be a novel drug for Alzheimer's disease (AD). We found that
APO
treatment ameliorated oxidative stress in an AD mouse model and specifically attenuated the hydrogen peroxide-induced p53-related apoptosis in the SH-SY5Y neuroblastoma cell line. To further understand the mechanism behind this action, we investigated the actions of
APO
on intracellular redox systems, such as the glutathione cycle and catalase. We studied the effects of specific inhibitors for
glutathione peroxidase
(GPx), glutathione reductase (GR), and catalase (BCNU, MCS, and ATZ, respectively) on the effects of
APO
. Treatments with MCS or BCNU, but not ATZ, significantly attenuated the protective effects of
APO
. Interestingly,
APO
treatment elevated GPx activity, but did not increase the expression of the GPx1 protein. Although BCNU treatment attenuated
APO
effects, GR activity was not elevated by
APO
treatment. The same effects were observed in primary neuronal cultures. In addition, treatment with dopamine D1, D2, D3 and D4 receptor antagonists did not counteract the protective action of
APO
. Thus,
APO
may enhance GPx activity through dopamine receptor-independent pathways.
...
PMID:Activation of glutathione peroxidase and inhibition of p53-related apoptosis by apomorphine. 2179 52
