Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.11.1.8 (thyroid peroxidase)
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Human Gene/Protein
thyroperoxidase 13.3
thyroid peroxidase 13.3
TPO 13.3
IGLON5 13.3
iodotyrosine deiodinase 13.2
dual oxidase maturation factor 2 12.7
THOX2 12.6
DEHAL1 12.3
ZSCAN31 12.3
THOX1 12.3
TPO protein 12.2
SNTG2 12.0
TPO mRNA 12.0
pM5 11.9
DUOXA2 11.8
TRIM61 11.7
SBNO1 11.7
ancient ubiquitous protein 1 11.7
Thyroid peroxidase 11.4
Pax-8 11.3
RNF33 11.3
LSM8 11.3
BEN domain containing 4 11.3
DUOX2 11.2
GLT25D2 11.0
CDH16 11.0
FOXE1 10.9
c-MPL 10.9
thyroid stimulating hormone receptor 10.9
TTF2 10.9
TPX 10.8
sodium iodide symporter 10.7
RTSH 10.7
DIO1 10.7
DUOXA1 10.7
AOI 10.6
THPO 10.5
C4orf7 10.5
NPTN 10.5
thyroglobulin 10.5
MGDF 10.4
SIOD 10.3
tenascin XB 10.3
TARSH 10.3
DUOX1 10.3
TPO1 10.2
Thyroglobulin 10.1
carboxypeptidase Z 10.1
LGSN 10.1
CEBPA protein 10.1
NIS 10.1
TG protein 10.1
TSHR 10.1
COL23A1 10.0
Dual oxidase 10.0
Thyroid stimulating hormone receptor 10.0
TSPEAR 10.0
megakaryocyte growth and development factor 10.0
thyrotropin receptor 9.9
Thyrotropin receptor 9.9
IGLV1 9.9
GPR135 9.9
HDLBP 9.9
dual oxidase 9.8
MYT1L 9.8
FNDC1 9.7
IMPG1 9.7
thrombopoietin receptor 9.7
thyroid protein 9.7
CBL-B 9.6
KCNRG 9.6
PXDN 9.6
EMCN 9.6
hTSHR 9.5
MPPED2 9.5
MBIP 9.5
FCRL2 9.5
ATP4B 9.5
FLT3L 9.4
ankyrin motif 9.4
more...
Disease
Transitory neonatal diabetes mellitus 13.3
Graves' disease with thyrotoxic crisis 13.3
Other thyroid disorders 13.3
Postpartum thyroiditis 11.4
Chronic thyroiditis 11.4
placental cancer 11.3
Autoimmune hypothyroidism 11.1
Chronic thrombocytopenia 10.7
autoimmune thyroid disease 10.5
Primary congenital hypothyroidism 10.3
PFCP 10.3
Subclinical hypothyroidism 10.3
Secondary hyperlipidemia 10.1
Congenital goiter 10.1
hyperthyroid heart disease 10.1
Hashimoto's thyroiditis 9.9
autoimmune thyroiditis 9.9
Congenital hypothyroidism 9.8
Silent thyroiditis 9.7
Hoffmann's syndrome 9.7
FPO 9.6
Hashitoxicosis 9.6
diffuse goiter 9.5
Thyroid tuberculosis 9.5
Graves' dermopathy 9.5
Nodular goiter 9.4
thyroid disorder 9.3
thyroiditis 9.3
Central hypothyroidism 9.2
Iron deficiency without anemia 9.2
Primary hypothyroidism 9.1
Gaze-evoked nystagmus 9.1
Immune thrombocytopenia 9.1
Endemic goiter 9.0
Graves' disease 8.9
Autoimmune hypophysitis 8.9
congenital hypothyroidism 8.8
acute thyroiditis 8.8
congenital amegakaryocytic thrombocytopenia 8.6
toxic nodular goiter 8.5
TSH hypersecretion 8.5
Pretibial myxedema 8.5
Idiopathic hypoparathyroidism 8.4
hypothyroidism 8.4
recurrent thyroid cancer 8.4
goiter 8.4
Lichen planus pigmentosus 8.4
vitamin B12 deficiency anemia 8.4
TSH deficiency 8.4
Chronic idiopathic urticaria 8.3
Latent autoimmune diabetes in adults 8.3
myxedema 8.2
multinodular goiter 8.2
toxic adenoma 8.1
subacute thyroiditis 8.1
Acute urticaria 8.1
hyperthyroidism 8.0
Graves' ophthalmopathy 7.8
Drug-induced hypersensitivity syndrome 7.8
T3 toxicosis 7.6
ADA-SCID 7.5
Thyroid gland 7.4
Iodine deficiency 7.4
Immune thrombocytopenic purpura 7.4
thyrotoxicosis 7.3
PDS 7.3
Myxedema coma 7.3
IDDM2 7.2
Quervain 7.1
anaplastic thyroid cancer 7.1
Riedel's thyroiditis 7.1
Distal renal tubular acidosis 7.1
Parry 7.0
thyroid nodule 7.0
thyroid adenoma 7.0
perception disorder 7.0
c-ALL 6.9
Struma ovarii 6.9
thyroid cancer 6.9
Hurthle cell carcinoma 6.9
more...
Symptom
quadrant anopsia 10.5
Pituitary enlargement 9.4
Cardiovascular symptoms 7.9
dysosmia 6.8
hyperemesis gravidarum 5.8
consciousness disturbance 5.6
periorbital edema 5.3
ketonuria 5.2
excessive sweating 5.1
myoclonus 4.7
cerebellar ataxia 4.7
Involuntary Movement 4.7
dry skin 4.3
polyuria 4.3
Decreased activity 4.3
ataxic gait 4.2
polydipsia 4.2
personality change 4.2
night sweats 4.1
neck stiffness 4.1
partial seizure 3.9
dysarthria 3.8
ataxia 3.5
neurological disability 3.5
hoarseness 3.4
muscle rigidity 3.2
catatonia 3.2
muscle stiffness 3.1
myalgia 3.0
tonic-clonic seizure 3.0
skin damage 2.8
enuresis 2.6
alexithymia 2.6
abdominal discomfort 2.6
hip pain 2.5
tremor 2.5
weakness 2.4
neck pain 2.4
chronic cough 2.3
fever of unknown origin 2.3
heartburn 2.3
insomnia 2.3
Ill 2.2
stridor 2.1
facial pain 2.1
fatigue 2.1
wheezing 2.1
dysuria 2.1
seizures 2.0
constipation 2.0
numbness 2.0
asthenia 1.9
shoulder pain 1.9
cachexia 1.9
lethargy 1.8
nausea and vomiting 1.7
exertional dyspnea 1.6
anorexia 1.6
dyspnea 1.5
vertigo 1.5
arthralgia 1.5
spasm 1.5
overweight 1.2
hepatosplenomegaly 1.2
splenomegaly 1.1
shortness of breath 1.0
Welt 0.9
headache 0.9
hunger 0.9
paresis 0.8
back pain 0.8
tinnitus 0.6
acidity 0.4
abdominal pain 0.4
vomiting 0.4
regurgitation 0.3
starvation 0.3
dystonia 0.3
syncope 0.1
angina -0.0
more...
Drug
Thyroglobulin 10.1
4-Methylimidazole 9.1
Myo-Inositol 9.0
Thyrogen 8.3
Synthroid 7.6
4-Hydroxytamoxifen 7.5
TFT 7.3
Brij 96 7.3
IL-11 7.3
Synthroid 6.9
Pegasys 6.8
Hydroxyethylstarch 6.6
Kelp 6.3
ID2 6.2
NaI 6.1
NaI 6.1
NaI 6.1
NaI 6.1
FSH-beta 6.1
2-Methoxyestradiol 5.9
G-CSF 5.9
PTC 5.7
Micafungin 5.7
C3H6 5.6
NOV 5.6
Mesalazine 5.5
Rutin 5.0
Amifostine 4.8
Retinoic Acid 4.8
Natalizumab 4.7
DM1 4.7
Lugol 4.7
Pronase 4.6
ISP 4.4
MTC 4.3
CSF 4.3
L-tyrosine 4.1
CFS 4.0
Isotretinoin 3.9
Rituximab 3.8
MDS 3.8
Campath 3.8
Campath 3.8
Riboflavin 3.7
GEO 3.7
Triclosan 3.7
Lipiodol 3.6
Methylprednisolone 3.5
Heme 3.3
PCB 3.3
G418 3.2
Aloe 3.1
Vitamin B12 3.0
NBT 2.9
Lovastatin 2.9
Glutathione 2.9
IL-1ra 2.9
Prednisolone 2.8
Vitamin A 2.7
balanced salt solution 2.7
MgSO4 2.7
Ranitidine 2.7
IL-2 2.7
Gel 2.6
CPR 2.6
Activin 2.6
Norplant 2.5
FAD 2.5
Bifidobacterium 2.4
Frontal 2.3
IFN-gamma 2.3
ACT 2.2
TAT 2.1
Ouabain 2.0
ROC 2.0
Forskolin 2.0
HCG 1.9
AZT 1.9
DNase I 1.9
CTX 1.9
more...
Enzyme
thyroid peroxidase 13.3
EC 1.7.1.11 13.3
glutathione-insulin transhydrogenase 9.8
protein disulfide-isomerase 7.6
iodothyronine 5'-deiodinase 7.2
arylsulfate sulfotransferase 7.0
21-hydroxylase 6.9
flavin reductase 6.7
chloroperoxidase 6.6
hatching enzyme 6.3
UMP kinase 6.1
STK 6.1
cytochrome c peroxidase 5.9
Lod 5.7
transglutaminase 5.6
peroxidase 5.4
SOR 5.3
NADH-cytochrome b5 reductase 5.3
glutamate decarboxylase 5.2
dimethylarginine dimethylaminohydrolase 5.1
ferredoxin reductase 5.0
glucose oxidase 4.9
proteinase-3 4.9
FPS 4.9
flavin-containing monooxygenase 4.8
nicotinamide phosphoribosyltransferase 4.8
CPR 4.7
NADPH oxidase 4.7
succinyl-CoA synthetase 4.6
beta-amylase 4.5
NPL 4.5
endoglycosidase H 4.5
cathepsin S 4.4
aldehyde reductase 4.3
PNGase F 4.3
aldehyde reductase 4.3
aldehyde reductase 4.3
dipeptidyl peptidase IV 4.2
adrenodoxin reductase 4.1
CD13 4.1
prostaglandin synthetase 4.1
STR 4.0
NADPH oxidase 4.0
SOR 3.8
ascorbate oxidase 3.7
TMT 3.7
MDH 3.7
thioredoxin reductase 3.6
MDH 3.6
tryptophan 2,3-dioxygenase 3.6
succinic dehydrogenase 3.6
lignin peroxidase 3.5
ferrochelatase 3.5
enolase 3.5
Rex 3.5
proprotein convertase 3.2
diaphorase 3.1
chloramphenicol acetyltransferase 3.0
glutathione peroxidase 3.0
tyrosine aminotransferase 3.0
peroxiredoxin 3.0
LPL 2.9
cathepsin D 2.9
gamma-glutamylcysteine synthetase 2.8
transpeptidase 2.8
deoxyribonuclease 2.8
Mg2+-ATPase 2.8
alpha-mannosidase 2.8
deoxyribonuclease 2.7
sialyltransferase 2.7
polo-like kinase 1 2.7
glucose-6-phosphatase 2.7
sialyltransferase 2.7
sialyltransferase 2.7
adenylate cyclase 2.7
trypsin 2.7
MIP 2.6
UDP-glucuronosyltransferase 2.6
PTA 2.6
glycerol-3-phosphate dehydrogenase 2.5
more...
Compound
4-propoxyphenol 12.3
2-Mercaptoimidazole 11.7
Phenthoate 10.1
TMTU 9.9
Ethylenethiourea 9.7
Trimethylolpropane triacrylate 9.7
PC-4 9.6
DIT 9.6
Trimeprazine 9.2
Ascaridole 9.2
BDMA 8.9
BDMA 8.8
TSH 8.8
1,3-thiazolidine-2-thione 8.7
Methimazole 8.7
BVE 8.6
Carbimazole 8.6
4-chloropyridine 8.6
MTU 8.3
2-iodophenol 8.3
Thyroid 8.3
PTU 7.9
4-Methylimidazole 7.8
PTU 7.6
diphenylphosphine oxide 7.6
Thyroxine 7.5
Zwittergent 3-14 7.4
TFT 7.3
2-methylbenzoic acid 7.3
Cortexolone 7.2
TPD 7.2
Propyl gallate 7.0
hexadecanal 7.0
dodecanal 6.9
dodecanal 6.9
Thiocyanate 6.9
hexadecanal 6.9
Methyl tert-butyl ether 6.8
Cepharanthine 6.8
iodine 6.8
MNT 6.8
Vitexin 6.7
Selenomethionine 6.6
SD 25 6.5
Triiodothyronine 6.5
Bisphenol S 6.5
Harmine 6.4
Mancozeb 6.4
L-T3 6.4
3,5-T2 6.3
PC-2 6.3
Se-methylselenocysteine 6.2
Bis-GMA 6.2
MNNG 6.2
C 6 6.1
PCB 126 6.0
Sulfonamide 5.9
2-Methoxyestradiol 5.9
DQ1 5.9
Thiram 5.9
Benzyl alcohol 5.8
CMK 5.7
T13 5.7
MIT 5.7
Thiram 5.7
Sibutramine 5.6
MIT 5.5
resorcinol 5.5
Amax 5.5
ITP 5.5
TMA 5.3
TMA 5.3
4-Hydroxynonenal 5.3
9H-carbazole 5.1
MPB 5.1
Cypermethrin 5.1
TRH 5.1
ANA 5.0
ANA 5.0
1-propanesulfonic acid 5.0
more...