Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.11.1.7 (
peroxidase
)
65,474
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Horseradish
peroxidase
reacts with H2O2 and other hydroperoxides to form Compound I, the first active enzymatic form
m-Chloroperoxybenzoic acid
, a xenobiotic hydroperoxide, acts as an oxidant substrate of horseradish
peroxidase
. However, this hydroperoxide is also a powerful inactivator of the enzyme and in this sense is more effective than H2O2. The coupled reductant substrates used in the peroxidatic reaction protect the enzyme from the inactivating process. A reaction mechanism is proposed with two competitive routes: one catalytic and one inactivating. Using a kinetic approach, the ratio between the hydroperoxide and the reductant substrate appears to be a decisive factor in the catalytic turnover of the enzyme. The role of the reductant substrates in protecting the enzyme, and the physiological and biotechnological implications of this process are discussed.
...
PMID:Role of the reductant substrates on the inactivation of horseradish peroxidase by m-chloroperoxybenzoic acid. 879 32
