Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.11.1.7 (peroxidase)
 65,474 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Possible roles for neutrophils in the response of sensitized rat uteri to a deciduogenic stimulus were investigated. Ovariectomized rats were sensitized for the decidual cell reaction by the administration of estradiol and progesterone. Sesame oil was injected into one uterine horn as a deciduogenic stimulus on the equivalent of Day 5 of pseudopregnancy. Neutrophil numbers in the endometrium, as determined by microscopy after application of the stimulus, were dependent on time and stimulation. Very few neutrophils were found in the endometrium before stimulation. To determine whether neutrophils were involved in the uterine responses to a deciduogenic stimulus, rats were depleted of circulating neutrophils by prior treatment with either methotrexate (MET) or antineutrophil serum (ANS). The increase in endometrial vascular permeability, as quantified with [125I]-BSA 10 h after stimulation, was not significantly affected by MET or ANS treatment, nor was the extent of decidualization, as indicated by the weight of the uteri 5 days after stimulation. Endometrial neutrophil numbers were significantly lower in the MET- and ANS-treated animals compared to their respective controls. In the uterus, activity of myeloperoxidase, an enzyme found mainly in neutrophils, was significantly reduced in MET-treated animals. To investigate the role of neutrophils in blastocyst implantation, we treated rats with ANS early on Day 5 of pregnancy. On Day 6, neither the numbers of implantation sites nor their weights were affected by ANS treatment. ANS treatment on Day 5 of pregnancy did not attenuate the numbers and weights of placentae and fetuses on Days 19 and 20 of pregnancy.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:An investigation into the role of neutrophils in decidualization and early pregnancy in the rat. 839 31

The aim of the study was to investigate the effect of sesame oil on acute kidney injury induced by the synergistic action of aminoglycoside and iodinated contrast in rats. Acute kidney injury was induced by a 5-day course of daily gentamicin injections (100 mg/kg of body weight, subcutaneously) and then iodinated contrast (4 ml/kg, intravenously) in male specific-pathogen-free Sprague-Dawley rats. Sesame oil (0.5 ml/kg, orally) was given 1 h before iodinated contrast. Renal function and oxidative stress were assessed 6 h after iodinated contrast injection. Renal function was evaluated by measuring serum blood urea nitrogen and creatinine levels. Renal oxidative stress was assessed by determining renal lipid peroxidation, myeloperoxidase, hydroxyl radical, superoxide anion, nitrite/nitrate, and inducible nitric oxide synthase levels. Sesame oil significantly prevented the rise of serum blood urea nitrogen and creatinine levels. Furthermore, there was a parallel inhibition of the rise in levels of expression of renal lipid peroxidation, myeloperoxidase, hydroxyl radicals, superoxide anion, nitrite/nitrate, and inducible nitric oxide synthase in rats with gentamicin-plus-iodinated contrast-induced acute kidney injury. We conclude that sesame oil may attenuate aminoglycoside-plus-iodinated contrast-induced acute kidney injury by inhibiting renal oxidative stress in rats.
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PMID:Sesame oil prevents acute kidney injury induced by the synergistic action of aminoglycoside and iodinated contrast in rats. 2140 54

Ketoconazole (KCZ) is the most commonly used systemic antifungal drug. However, long-term treatment of KCZ induces hepatic injury. Oxidative stress is involved in KCZ-induced hepatic injury. Oxidative stress plays an important role in apoptosis-associated hepatic damage. Sesame oil is rich in potent antioxidants and antifungal constituents. It attenuates hepatic injury by inhibiting oxidative stress. Thus, sesame oil may protect against KCZ-induced oxidative stress, apoptosis and hepatic damage. The aim of the present study was to investigate the protective effect of sesame oil as a nutritional supplement on KCZ-induced hepatic injury in mice. KCZ (300 mg/kg/day) was administered by gastric intubation; 30 min later, sesame oil (0, 0.0625, 0.125, 0.25 or 0.5 ml/kg/day; p.o.) was administered to mice for 14 days. Blood and liver tissue were collected. Hepatic injury was evaluated by serum biochemistry and histology. Oxidative stress was evaluated by myeloperoxidase activity, p47-phox, reactive oxygen species generation, lipid peroxidation and glutathione level. Apoptosis was evaluated by p53, caspase-3, Bcl-2, Bax and Cyto-C expression. Osteopontin was measured to assess liver healing. Sesame oil attenuated hepatic injury; it also decreased oxidative stress and apoptosis in KCZ-treated mice. Sesame oil may be used as a nutritional supplement with existing antifungal therapies to neutralize the adverse hepatotoxic nature of antifungal drugs by attenuating hepatic apoptosis through redox system to protect and heal liver injury in KCZ-treated mice.
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PMID:Daily sesame oil supplementation mitigates ketoconazole-induced oxidative stress-mediated apoptosis and hepatic injury. 2761 44