Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.11.1.7 (peroxidase)
 65,474 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Acute reversible lesion in the medial preoptic area (MPOA) by unilateral injection of the local anesthetic lidocaine chlorhydrate (1 microliter, 20 ng/microliters) causes a transient increase in water intake induced by water deprivation in rats. Since lidocaine suppresses the nervous activity, leaving intact fibers of passage and blood vessels, the results suggest an intrinsic inhibitory action of the MPOA on the regulation of water intake. Drinking elicited a return to volumes similar to those of control rats, 3-4 h after lidocaine administration. Lidocaine released into the lateral preoptic area (LPO) slightly decreased or did not change water intake, as compared with controls. The urinary excretion in the MPO group was higher than that of the controls and the LPO, while this last group excreted significantly less urine. The ablation of the POA with lidocaine suggests that the medial aspect of the POA has an intrinsic inhibitory factor influencing drinking, while the lateral aspect did not show a relevant effect.
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PMID:The involvement of the hypothalamic preoptic area on the regulation of thirst in the rat. 145 40

An enzyme immunoassay for POA prepared by Gelder et al. was developed in our laboratory. Elevated serum POA levels were shown in 70.6% (36/51) of patients with pancreatic cancer. POA levels were related neither to the stage nor to the degree of differentiation of pancreatic cancer. Although POA levels were not elevated in patients with benign diseases of the pancreas, they were elevated in patients with cancer of the hepato-biliary tract. In pancreatic cancer patients with pre-operative high POA levels, serial POA determinations following tumor resection are considered to be useful for detecting recurrence of disease. Employing the unlabeled antibody peroxidase-antiperoxidase (PAP) method, POA was detected in the cytoplasm of cancer cells in 80.0% (28/35) of pancreatic cancer patients, but not in histologically normal pancreatic tissue. Well differentiated cancer cells showed higher POA stainability than less differentiated ones. POA was also detected in fetal pancreas tissues of 22 weeks gestation, but not in those of 12-16 weeks gestation. This result suggests that POA is an oncofetal antigen.
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PMID:[Studies on a pancreatic oncofetal antigen (POA) in patients with pancreatic cancer]. 378 34