Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.11.1.7 (peroxidase)
 65,474 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A new model of traumatic axonal injury has been developed by causing a single, rapid, controlled elongation (tensile strain) in the optic nerve of the albino guinea pig. Electron microscopy demonstrates axonal swelling, axolemmal blebs, and accumulation of organelles identical to those seen in human and experimental brain injury. Quantitative morphometric studies confirm that 17% of the optic nerve axons are injured without vascular disruption, and horseradish peroxidase (HRP) studies confirm alterations in rapid axoplasmic transport at the sites of injury. Since 95% to 98% of the optic nerve fibers are crossed, studies of the cell bodies and terminal fields of injured axons can be performed in this model. Glucose utilization was increased in the retina following injury, confirming electron microscopic changes of central chromatolysis in the ganglion cells and increased metabolic activity in reaction to axonal injury. Decreased activity at the superior colliculus was demonstrated by delayed HRP arrival after injury. The model is unique because it produces axonal damage that is morphologically identical to that seen in human brain injury and does so by delivering tissue strains of the same type and magnitude that cause axonal damage in the human. The model offers the possibility of improving the understanding of traumatic damage of central nervous system (CNS) axons because it creates reproducible axonal injury in a well-defined anatomical system that obviates many of the difficulties associated with studying the complex morphology of the brain.
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PMID:Axonal injury in the optic nerve: a model simulating diffuse axonal injury in the brain. 274 48

Effect of hydrocortisone, NaF, and FeSO4 on ligninolytic and phosphatase activity of the fungus Lentinus (Panus) tigrinus VKM F-3616D was investigated, Hydrocortisone and NaF were shown to inhibit the enzymes of the ligninolytic complex-laccase (EC 1.10.3.2), secretory peroxidase (EC 1.11.1.7), and Mn peroxidase (EC 1.11.1.13). FeSO4 exhibited no significant effect on the activity of these enzymes. Decreased activity of the enzymes of the ligninolytic complex was associatedwith inhibition of the activity and changes in the substrate specificity of phospholipase A2 (EC 3.1.1.4) in the presence of hydrocortisone of NaF. Cultivation of L. tigrinus in the presence of these compounds resulted in higher affinity of this enzyme to saturated fatty acids, while in the control and in the presence of FeSO4 affinity to unsaturated fatty acids was higher.
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PMID:[Relation between ligninolytic and phospholipase activities in the fungus Lentinus tigrinus]. 2584 53