Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.11.1.7 (peroxidase)
 65,474 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The synaptic organization of projections from the lateral mammillary neurons within the dorsal tegmental nucleus of Gudden is studied in the rat with the aid of anterograde transport of horseradish peroxidase conjugated with wheat germ agglutinin (WGA-HRP) and visualized with tetramethylbenzidine. The dorsal tegmental nucleus consists of the pars ventralis (TDV) and the pars dorsalis (TDD). The normal neuropil of the dorsal tegmental nucleus contains three classes of axodendritic terminals, that is, terminals containing round, flat, and pleomorphic vesicles. They make up 44%, 5%, and 51%, respectively, of all axodendritic terminals in the TDV, and 62%, 1%, and 37% in the TDD. Injection of WGA-HRP into the lateral mammillary nucleus permits ultrastructural recognition of many anterograde labeled terminals within both the TDV and TDD. In the TDV, 81% of the labeled terminals contain round synaptic vesicles and make asymmetric synaptic contacts. A few of the labeled terminals contain pleomorphic vesicles and make symmetric synaptic contacts. More than 50% of the labeled terminals contact intermediate dendrites (1-2 microns diameter). In the TDD, almost all labeled terminals are small, contain round vesicles, and make asymmetric synaptic contacts. These terminals mainly contact intermediate as well as distal (less than 1 micron diameter) dendrites. There are only a few labeled terminals with pleomorphic vesicles and no terminals with flat vesicles. The termination pattern of the lateral mammillary neurons in the TDV is similar to that in the TDD. Anterograde labeled axon terminals often contact retrograde labeled dendrites in the TDV. No reciprocal connections are present in the TDD. These results suggest that the TDV and the TDD receive mainly excitatory and a few inhibitory inputs from the lateral mammillary nucleus. The TDV neurons also have direct reciprocal connections with the lateral mammillary neurons.
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PMID:Fine structure of the lateral mammillary projection to the dorsal tegmental nucleus of Gudden in the rat. 169 33

The regions projecting to Gudden's tegmental nuclei were examined by retrograde transport of horseradish peroxidase or wheat-germ-agglutinin-conjugated horseradish peroxidase. Gudden's tegmental nuclei in the rabbit can be divided into a pars principalis of the ventral tegmental nucleus (TVP), a pars ventralis of the dorsal tegmental nucleus (TDV), and a pars dorsalis of the dorsal tegmental nucleus (TDD). The TVP receives many fibers from the medial division of the ipsilateral medial mammillary nucleus and bilaterally from the lateral habenular nucleus, and additionally some fibers from the posterior nucleus of the interpeduncular complex. The TDV receives many fibers from the ipsilateral lateral mammillary nucleus, from the ipsilateral prepositus hypoglossi nucleus, bilaterally from the lateral habenular nucleus, from the central and paramedian nuclei of the interpeduncular complex, from the bilateral gray matter along the floor of the fourth ventricle, and from the contralateral supragenual nucleus. The TDD receives a projection from the lateral habenular nucleus of both sides and from the central and paramedian nuclei of the interpeduncular complex, and a minor projection from the ipsilateral lateral mammillary nucleus, the posterior nucleus of the interpeduncular complex, the prepositus hypoglossi nucleus, and the contralateral supragenual nucleus.
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PMID:Afferent connections of Gudden's tegmental nuclei in the rabbit. 392 61

Mammillary projections from each subnuclei of Gudden 's tegmental nuclei were investigated by retrograde transport of horseradish peroxidase (HRP) in the cat, rat, guinea pig, golden hamster and house shrew (Suncus murinus, Insectivora). The dorsal tegmental nucleus of Gudden (TD) is composed of the pars dorsalis (TDD) and the pars ventralis ( TDV ) in the cat, rat, guinea pig, and golden hamster, but the TD of the house shrew can not be divided. The ventral tegmental nucleus of Gudden (TV) is composed of the pars principalis (TVP) and the pars suprafascicularis ( TVS ) in the golden hamster and house shrew, but the TVS is not recognized in the cat, rat and guinea pig. The TDV projects to the lateral mammillary nucleus, and the TVP projects to the medial mammillary nucleus ipsilaterally in the cat, rat, guinea pig and golden hamster. The TVS of the golden hamster projects to the medial mammillary nucleus. The TVP and TVS of the house shrew project to the medial mammillary nucleus, and the TVS also to the lateral mammillary nucleus. In addition, the pars compacta of the nucleus centralis superior projects to the medial mammillary nucleus in the rat, guinea pig and golden hamster. However, the TDD sends no fibers to the mammillary nuclei in these 5 species of mammals.
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PMID:Comparative anatomical study of the tegmentomammillary projections in some mammals: a horseradish peroxidase study. 642 1