Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:1.11.1.6 (catalase)
 55,569 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

About 4 cases of arterio-veinous malformations located within the occipito-cerebello-mesencephalic dihedral (which is this region of the brain including the cistern of Galen and the surrounding formations : the quadrigeminal bodies forwards, the splenium of the corpus callosum upwards, the upper face of the cerebellum and the pedonculus cerebellaris superior below) the authors related their own experience. These 4 cases are detailed from a clinical point of view. Them, a synthetic study is undertaken in which a comparison is done between the literature and the clinical features encountered : headache, sub-archnoid hemorrhage, impairment of consciousness, clinical features such as cranial nerve impairment, nystagmus motor impairment, cerebellar deficit, hydrocephaly. The value of angiography, ventriculography and CAT is discussed. All these patients have been operated upon as far as the authors think that a better chance can thus be offered to them. The choice of the technique is discussed. For one patient, the sub-temporal route was performed ; but it seems worth using the posterior inter-occipital route : this allows a better view on the lesion and an easier treatment of the malformation. These 4 patients suffered post operatively of a visual defect. The control angiography revealed no more arterio-venious malformation in two patients, a mild one in two others.
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PMID:[Arterio-veinous malformations located within the occipito-cerebello-mesencephalic dihedral (author's transl)]. 31 28

Fifteen normal children with large heads (circumference greater than 0.5 cm above the 98th centile) were studied. CAT scans were pefrormed to exclude hydrocephalus, and ventricular size was compared with that of hydrocephalic children. In 11 of the 13 families in which the parents' heads were measured, one parent (10 fathers and one mother) was found to have a large head, as had 6 of 17 siblings. Head circumference at birth was large in 7 of 10 babies and rate of head growth was excessive in 8 of 13. Skull x-ray showed suture diastasis in 7 infants. These families have a benign familial megalencephaly. It is important to recognise this so as to avoid unnecessary investigation and anxiety about normal children with large heads.
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PMID:Normal children with large heads--benign familial megalencephaly. 31 81

The injury-vasospasm hypothesis of IHD was discussed in relation to coronary artery autoregulation and the anoxic-feedback mechanism. Observations in the recent literature, not usually attributed to spasm, were examined in light of this phenomenon. This includes reperfusion models of experimental AMI, the association of AMI with myocarditis, and findings in AMI and SCD as necrotic microlesions, prodromata, and epicardial arterial plaque rupture and hemorrhage. The disparity between the severity of coronary disease and the occurrence of the various types of IHD suggest that atherosclerosis itself does not precipitate attacks of chest pain. It was emphasized that plaque rupture due to spasm might help induce CAT. With exercise, the possible importance of the autoregulatory system was explored in the prevention and induction of AMI and SCD, and the improvement of AP. The role of spasm in IHD should be defined.
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PMID:The injury-vasospasm hypothesis of ischemic heart disease, revisited. 33 91

Naturally occurring isolates of chloramphenicol-resistant bacteria commonly synthesise chloramphenicol acetyltransferase (EC 2.3.28; CAT) in amounts which are sufficient to account for the resistance phenotype and often harbour plasmids which carry the structural gene for CAT. The findings of CAT in such diverse prokaryotes as Proteus mirabilis, Agrobacterium tumefaciens, Streptomyces sp., and a soil Flavobacterium has led to speculation concerning the origin and evolution of the more commonly observed CAT variants specified by plasmids in clinically important bacteria. To provide a more solid basis for studying the evolution and spread of CAT within prokaryotes we chose to determine the complete amino acid sequence of a type I variant of CAT, the variant known to be associated with most F-like plasmids conferring chloramphenicol resistance. The sequence has been determined by combining the results obtained from manual and automated sequential degradation with those obtained by mass spectrometry of peptides generated by enzymatic digestion. The directly determined primary structure is identical with that predicted by the DNA sequence analysis of the chloramphenicol resistance transponson Tn9 known to specify a type I variant of chloramphenicol acetyltransferase.
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PMID:Primary structure of a chloramphenicol acetyltransferase specified by R plasmids. 39 Apr 4

The radionuclide, CAT and angiographic features of a case of herpes simplex encephalitis are present. A dramatic change in the abnormal perfusion and static concentration of tracer activity resulted following chemotherapy with Adenine arabinoside. The improvement seen on the dynamic and static scintiscans correlates closely with the patient's clinical course and CAT findings. The radionuclide perfusion study is of particular importance in documenting the diminished activity of the inflammatory process following therapy.
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PMID:Scintiscans and computer assisted tomographic findings of herpesencephalitis. 42 95

Two patients with orbital pseudotumor, demonstrated by computerized axial tomography (CAT scan), are presented. This radiological technique was further used to demonstrate the complete resolution (Case 1) and marked regression (Case 2) of the orbital masses after steroid therapy. CAT scan characteristics of orbital pseudotumor were discussed and contrasted with the findings in thyroid ophthalmopathy. It is our recommendation that patients with CAT scan and clinical characteristics of orbital pseudotumor should be treated with systemic steroids and resolution of the inflammatory lesion should be corroborated by a repeat scan in atypical cases. Orbital surgery and other invasive studies should be used in those patients in whom there is no objective improvement in the disease process.
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PMID:Use of computerized axial tomography (CAT scan) in evaluating therapy of orbital pseudotumor. 43 40

Sixty patients with severe head injury who did not have an acute intracranial haematoma on CAT scanning are reviewed. The scans are correlated with the level of consciousness at the time of scanning and with the outcome six months after injury. The initial scan was interpreted as being normal in 38% of the cases. In the remainder the most common abnormalities were small ventricles and areas of mixed increased and decreased density interpreted as contusions. All the patients with small ventricles were under 20 years of age. Postmortem examinations were undertaken on 15 of the 19 fatal cases. There was evidence of a high intracranial pressure in 12, cerebral contusions were absent or minimal in 10, there was diffuse immediate impact damage to white matter in six, and there was moderate or severe hypoxic damage in four.
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PMID:Computerised tomography after recent severe head injury in patients without acute intracranial haematoma. 43 29

A 62 year old, right handed man developed a pure agraphia as the result of a left temporal lobe stroke. Isolated writing disturbances persisted for seven months until he had a second cerebrovascular accident resulting in total aphasia and right hemiplegia. A CAT scan obtained four months after the first episode showed a localised dilatation of the posterior portion of the left Sylvian cistern and patchy areas of low absorption in the left temporal lobe. The report supports suggestions that localised damage to the language area can produce a pure agraphia as the sole detectable disorder of language organisation.
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PMID:Pure agraphia: a discrete form of aphasia. 43 36

Lesions involving the base of the skull can be divided into primary and secondary disease processes. The primary group consists of bone lesions more often seen elsewhere in the skeletal system while the secondary group consist of those lesions extending to the base of the skull by direct extension from adjacent intracranial or extracranial sites. The purpose of this paper will be to arrive at a classification of skull base lesions based on the roentgen localization of the disease process. The base of the skull because of its anatomically variable curvature can be difficult to evaluate on good quality conventional radiographs. In addition to the changing angles of the bone itself, the overlying soft tissues of the pharynx and neck only serve to further conceal areas of bone pathology. The advent of polytomography and CAT scanning has greatly aided the evaluation of this region which clinically is extremely difficult to assess. In some instances invasive modalities such as angiography and posterior fossa myelography are necessary to define the lesion. With these diagnostic methods available, rather than discovering classical patterns of disease, a variety of disease processes have been found that radiographically mimic each other. Similarly, on a purely clinical basis, many of the disease entities present in a similar fashion. It is only by a combined approach that an intelligent differential diagnosis can be offered.
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PMID:A clinical-radiographic classification of skull base lesions. 44 50

Thirty-nine patients with various types of isolated homonymous hemianopias resulting from ischaemic lesions in the posterior parts of the cerebral hemisphere was examined by CAT scanning. Most had localised low density lesions withing the distribution of the posterior cerebral artery. The location of the lesion (deduced from a separate anatomical study of postmortem brain cut in the plane of the CAT scanner) was correlated with visual field defects. Lesions giving rise to quadrantic defects were smaller than those causing total hemianopias; lower quadrantic defects tended to occur in superior cuts and vice versa. Macular sparing was associated with survival of the occipital pole in some instances. Bilateral cases had a higher prevalence of associated defects.
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PMID:Correlation of CAT scan and visual field defects in vascular lesions of the posterior visual pathways. 45 77


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