Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.10.3.3 (ascorbate oxidase)
 778 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

African Americans are nearly twice as likely to have diabetes mellitus than White Americans (Padonu, 1994). Diabetic retinopathy affects approximately 11 million Americans, which means that statistically, almost two-thirds of them are Black. It is the leading cause of blindness in persons age 20-74, and accounts for over 5,000 new cases annually (Smith, 1992). Blindness is 25 times more common in diabetics than in nondiabetics (Harris, 1987). The prevalence of diabetic retinopathy increases with the duration of the diabetes. Many studies of patients with type 1 diabetes diagnosed under the age of 30 have reported a direct relationship between prevalence and severity (AAO, 1989).
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PMID:Keeping good vision with diabetic retinopathy: a nursing responsibility. 882 67

The ability of vitamins C, E and K to inhibit enzymes directly has been investigated. It was found that vitamin E and some analogs and menadione (vitamin K3) inhibited several enzymes irreversibility at concentrations below one millimolar. Ascorbate inhibits rabbit muscle 6-phosphofructokinase (MPFK-1; EC 2.7.1.11), muscle type LDH (EC 1.1.1.27), and muscle AK (EC 2.7.4.3) at low concentrations that do not inhibit equivalent liver isozymes. Ascorbate Ki values for muscle-type LDH and heart-type LDH isozymes are 0.007 and 3 mM, respectively. The ascorbate Ki value for rabbit skeletal muscle PFK-1 is 0.16 mM; liver PFK-I is not inhibited by ascorbate. Dehydroascorbate does not inhibit any enzyme at ascorbate concentrations normally found in cells. All ascorbate inhibitions are completely reactivated or nearly so by L-ascorbate oxidase, CYS, GSH, or DTT. We propose a hypothesis that ascorbate facilitates glycogen storage in muscle by inhibiting glycolysis. The relationship between ascorbate metabolism and diabetes is discussed.
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PMID:Inhibition of rabbit muscle isozymes by vitamin C. 1081 Oct 33