Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.10.3.2 (laccase)
 4,656 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In this study, we used a simple in-situ biomineralization method to immobilize Bacillus subtilis (B. subtilis)-derived laccase into the copper-Trimesic acid framework (Cu-BTC), and the synthesized Laccase@Cu-BTC particles were used to degrade tetracycline and ampicillin. Compared with free laccase, the Laccase@Cu-BTC showed 16.5-fold of activity recovery, higher thermo-tolerant performance, more excellent acid-proof ability and reusability. Without any mediators, Laccase@Cu-BTC displayed high degradation efficiency (nearly 100%) for tetracycline and ampicillin in some actual water. The degradation mechanism and proposed degradation pathways of tetracycline and ampicillin were discussed technically. Besides, bacteriostatic assay and survival test of Escherichia coli (E. coli) and B. subtilis confirmed the loss of antibiotic activity for tetracycline and ampicillin, as well as the low ecotoxicity of the degradation products. Our research demonstrates that Laccase@Cu-BTC has excellent performance in the effective removal of antibiotics and the detoxification of degradation products, which make it a promising candidate for environmental recovery.
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PMID:An effective in-situ method for laccase immobilization: Excellent activity, effective antibiotic removal rate and low potential ecological risk for degradation products. 3224 49