Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.10.3.2 (
laccase
)
4,656
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The molecular mechanisms underlying the response of ectomycorrhizal fungi to heavy metals in general and cadmium in particular remain poorly understood. We screened 2040 arrayed cDNAs of the ectomycorrhizal fungus Paxillus involutus to identify cadmium-responsive genes by using differential hybridization. Forty nine (2.4%) of the 2040 cDNAs were differentially expressed, among which transcripts coding a
laccase
, an aconitase, and a metallothionein were upregulated by 3.9-, 3.7- and 2.8-fold, respectively, whereas genes coding hydrophobins and
threonine dehydratase
were strongly downregulated. Our results suggest that complexation of cadmium by phenolic compounds, or by complexing peptides such as metallothioneins, is probably key determinant of the cellular response to cadmium in P. involutus. In addition, the present study suggests that the synthesis of hydrophobins may be efficiently reduced, thus redirecting Cys to the manufacture of Cys-enriched compounds.
...
PMID:Transcriptomic responses to cadmium in the ectomycorrhizal fungus Paxillus involutus. 1549 73
