Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.10.3.2 (
laccase
)
4,656
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Owing to the ubiquitous availability and simple biocatalysis, the anti-proliferative
laccase
holds enormous opportunities for anti-cancer applications. However, accessing efficient and specific (super-magnetically targetable) new delivery system for anti-proliferative
laccase
is vital step towards
laccase
based anti-cancer approach. Therefore, in this investigation, super-magnetized (Fe
3
O
4
) and chitosan (CS) functionalized halloysite nanotubes (HNTs) (termed as Fe
3
O
4
-HNTs-CS) was facile synthesized. Further,
laccase
from Trametes versicolor was immobilized on Fe
3
O
4
-HNTs-CS (termed as Fe
3
O
4
-HNTs-CS-Lac). Then free
laccase
and Fe
3
O
4
-HNTs-CS-Lac were evaluated for anti-proliferative properties against cancer cell lines of liver (HepG2), lung (H460), cervix (Hela) and stomach (
AGS
). Laccase and Fe
3
O
4
-HNTs-CS-Lac gave significant cytotoxicity against all studied cancer cell lines. Moreover, the apoptosis analysis and FE-SEM morphology observations of cells support the anti-proliferative potential of
laccase
immobilized on Fe
3
O
4
-HNTs-CS. Therefore, investigated Fe
3
O
4
-HNTs-CS-Lac is natural and super-magnetic nano-biocatalyst, having the significant anti-proliferative potential and furthermore, Fe
3
O
4
-HNTs-CS can be used as efficient and specific delivery system for other anti-cancer enzymes.
...
PMID:Anti-proliferative applications of laccase immobilized on super-magnetic chitosan-functionalized halloysite nanotubes. 2991 93
