Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.10.3.1 (tyrosinase)
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Human Gene/Protein
cAMP-dependent protein kinase catalytic subunit gamma 11.8
two pore segment channel 2 11.8
cAMP-dependent protein kinase type II-alpha regulatory subunit 11.8
SNRP116 11.8
tyrosinase precursor 11.8
tyrosinase related protein-2 11.8
RNA binding motif protein 9 11.8
tyrosinase 11.7
Tyrosinase 11.4
TRP-1 11.4
TRP-2 11.3
tyrosinase-related protein-1 11.2
tyrosinase-like 11.1
tyrosinase-related protein 1 11.1
tyrosinase-related protein-2 11.0
TYRP2 10.9
dopachrome tautomerase 10.9
cAMP-dependent protein kinase type II-beta regulatory subunit 10.8
TFECL 10.8
MELPH 10.8
integral membrane transporter protein 10.8
microphthalmia-associated transcription factor 10.7
microphtalmia-associated transcription factor 10.6
Tyrosinase-related protein 1 10.5
Tyrosinase-related protein-2 10.5
Hermansky-Pudlak syndrome type 1 10.5
MITF protein 10.3
oculocutaneous albinism II 10.3
TRP2 10.3
DDCT 10.2
TYRL 10.2
TCRAV2S1 10.2
NAALADase II 10.2
WS2A 10.2
collagen type V alpha 1 10.2
tyrosinase-related protein 2 10.2
Paired box 3 10.0
gp100 9.9
TYRP1 protein 9.9
ANKRD27 9.8
collagen XXI 9.8
homeobox D9 9.8
MART1 9.7
MART-1 9.7
MAGE-3 9.6
OS-9 protein 9.5
XPA binding protein 1 9.5
TYRP1 9.5
CSNK1G3 9.5
SLC12A7 9.5
PAPOLB 9.5
SILV 9.4
TYR 9.4
MITF 9.3
RAB32 9.3
Melan-A 9.2
DCIP 9.2
MITF-C 9.2
rd5 9.2
TRP1 9.2
MATP 9.0
Mitf 9.0
ASMTL 9.0
helix-loop-helix zipper protein 9.0
BAGE 8.9
PIG1 8.8
PCPE 8.8
MAGE1 8.8
melanocortin 1 receptor 8.8
MAGE-2 8.7
HLA-B*4403 8.6
CAPN6 8.6
RUTBC1 8.6
Tissue-specific extinguisher 1 8.6
Adapter protein 8.6
MNT 8.6
MSH receptor 8.5
HPS5 8.5
HPS3 8.5
MAGE3 8.5
more...
Disease
Oculocutaneous albinoidism 11.8
WS2-OA 11.8
OCA1B 11.2
OCA3 10.9
Pigmentary incontinence 10.2
OCA4 10.0
Cervical Carcinoma 9.8
ROCA 9.5
Postinflammatory hypopigmentation 9.5
Cross syndrome 9.3
TSC3 9.2
melasma 9.0
melanoderma 8.9
freckles 8.8
Premature graying 8.8
Spindle cell melanoma 8.8
Generalized vitiligo 8.7
leukoderma 8.5
X-linked ocular albinism 8.4
canities 8.4
amelanotic melanoma 8.2
Riehl's melanosis 8.2
ATN 8.1
Mixed tumor 8.0
stage IV melanoma 7.9
Bonnier 7.8
Erythema dyschromicum perstans 7.7
Segmental vitiligo 7.7
EA3 7.5
vitiligo 7.4
Hermansky-Pudlak syndrome 7.2
lentigo 7.0
junctional nevus 7.0
HFH 7.0
stage II melanoma 7.0
Vogt-Koyanagi 6.9
WS4 6.8
dyschromia 6.8
melanoma 6.8
Waardenburg syndrome 6.6
Melanoma 6.6
melanoma stage 6.4
Triton tumor 6.4
Metastatic malignant melanoma 6.4
melanosis coli 6.3
multiple nevi 6.3
stage I melanoma 6.3
melanosis 6.2
Polymorphic light eruption 6.2
metastatic melanoma 6.1
ochronosis 6.0
Lentigo maligna 6.0
nRNA 6.0
stage III melanoma 6.0
WS1 5.9
PAL 5.8
Biotin deficiency 5.8
recurrent melanoma 5.7
ARP1 5.6
Civatte 5.6
SAMS 5.6
Bergeron 5.6
Fusarium infection 5.5
Fowlpox 5.5
Becker's nevus 5.5
Enzyme inhibition 5.4
compound nevus 5.4
PBT 5.4
Gliosarcoma 5.4
PEComa 5.3
HHP 5.3
Harada 5.3
benign nevi 5.2
Atypical fibroxanthoma 5.2
evaluable disease 5.2
Menkes 5.2
cutaneous melanoma 5.2
rind 5.2
Irritant contact dermatitis 5.1
CBS deficiency 5.1
more...
Symptom
Lightening 8.2
Overlying 5.3
skin damage 4.8
skin irritation 4.6
Spots 4.5
menometrorrhagia 4.5
skin irritant 4.2
ACHE 3.9
photophobia 3.7
DNA marker 3.5
acidity 2.9
Hudson 2.7
Decreased activity 2.7
fasciculation 2.4
chills 2.3
erythema 2.2
HSA 1.8
emaciation 1.7
microbial colonization 1.7
dental pain 1.5
physical appearance 1.2
thinning 1.1
agitation 0.8
pallor 0.5
exhaustion 0.4
nausea 0.3
starvation -0.0
collapse -0.0
memory loss -0.0
tremor -0.4
ENT -0.6
vomiting -0.6
cachexia -0.7
lethargy -0.7
paresis -0.7
hypotonia -0.7
flushing -0.9
myalgia -0.9
ataxia -1.2
dystonia -1.3
insomnia -1.6
diarrhea -1.7
cough -1.8
stigma -1.9
functional recovery -1.9
anorexia -2.0
dyspnea -2.0
weakness -2.4
pain -2.9
analgesia -3.0
anesthesia -3.4
fatigue -3.9
headache -4.0
Drug
Skinoren 9.5
Cysteine hydrochloride 8.8
Angelica dahurica root 8.6
Axokine 8.6
Tinosorb S 8.5
L-tyrosine 8.4
Uvinul 8.3
Gly-Tyr-Gly 8.0
Equilenin 7.6
Phosphomycin 7.5
Sesamol 7.5
3,4-Dihydroxyphenylalanine 7.5
Aescin 6.7
Ephedrae Herba 6.4
Hoelen 6.4
Voglibose 6.4
Sodium metabisulfite 6.3
Ozagrel 6.3
Bethanidine 6.1
DOXY 6.1
Latanoprost 6.1
Sodium ascorbate 6.0
PBZ 6.0
Pancreatin 6.0
Violaxanthin 5.8
Sulla 5.8
KAN 5.6
Peppermint 5.5
Ciglitazone 5.5
Glycyrrhiza 5.5
Carbidopa 5.4
Zinc sulfate 5.2
Azacytidine 5.2
Zinc sulfate 5.2
Ddc 5.2
Aloe 5.1
Premarin 5.1
Clove 5.1
Compound 16 5.1
Perphenazine 5.1
Ethylenediamine 5.0
CMX 5.0
Cinnarizine 5.0
Red ginseng 4.9
Swertia 4.9
Compound 9 4.8
Zmax 4.7
Palmitoyl 4.6
Xanthan gum 4.6
ROX 4.5
FLM 4.5
Senna 4.5
Methyldopa 4.5
Senna 4.4
Malachite Green 4.3
Bentonite 4.3
Tannic acid 4.2
Camphor 4.2
Camphor 4.1
Estriol 4.0
Trifluoperazine 4.0
Epigallocatechin 4.0
Hyaluronidase 4.0
Viagra 3.9
Ammonium chloride 3.9
ISP 3.9
citric acid 3.9
Loratadine 3.9
ascorbate 3.8
Crystal Violet 3.8
Hyaluronidase 3.8
Rasburicase 3.8
Asparaginase 3.8
Propidium 3.8
Cobalamin 3.7
Sinemet 3.7
Areca 3.7
Papain 3.7
Retinoic acid 3.6
Zein 3.6
more...
Enzyme
tyrosinase 11.8
catechol oxidase 11.8
aureusidin synthase 11.2
phenol oxidase 10.9
GriF 10.8
2-methylisocitrate dehydratase 10.8
quercetin 3-O-methyltransferase 10.2
DCF 9.8
dihydrobenzophenanthridine oxidase 9.5
pterin-4alpha-carbinolamine dehydratase 9.2
aryl-alcohol oxidase 9.1
geraniol dehydrogenase 9.0
shikimate dehydrogenase 8.0
hexose oxidase 7.9
p-hydroxyphenylacetate 3-hydroxylase 7.7
PAL 7.5
glutathione oxidase 7.5
azoreductase 7.4
laccase 7.3
ascorbate oxidase 7.0
pectin methylesterase 7.0
lignin peroxidase 6.9
AAE 6.9
clavaminate synthase 6.8
cyanide hydratase 6.7
12-oxophytodienoate reductase 6.6
ascorbate peroxidase 6.6
histidase 6.5
beta-agarase 6.4
caffeoyl-CoA O-methyltransferase 6.4
NAD+ kinase 6.4
endomannosidase 6.4
ent-kaurene oxidase 6.4
polysaccharide deacetylase 6.3
oxalate oxidase 6.2
salicylate hydroxylase 6.1
N-acetylglucosaminyltransferase V 6.1
neopullulanase 6.0
FTR 6.0
CPA2 5.9
homogentisate 1,2-dioxygenase 5.8
tyrosine decarboxylase 5.8
chitin deacetylase 5.7
chitinase 5.7
retinal dehydrogenase 5.7
phenylalanine hydroxylase 5.6
EC 4.4.1.5 5.5
isoflavone reductase 5.5
NADPH:quinone oxidoreductase 5.5
anthocyanidin reductase 5.5
bilirubin oxidase 5.4
tyrosine phenol-lyase 5.3
tannase 5.3
PAL 5.3
isovaleryl-CoA dehydrogenase 5.2
peroxidase 5.2
chalcone isomerase 5.2
prephenate dehydrogenase 5.2
Lod 5.2
leucine dehydrogenase 5.1
cinnamate 4-hydroxylase 5.1
glucose dehydrogenase 5.1
uracil phosphoribosyltransferase 5.1
sucrose phosphorylase 5.1
stilbene synthase 5.1
porphobilinogen deaminase 5.0
urease 5.0
cytokinin oxidase/dehydrogenase 5.0
4CL 5.0
cholinesterase 5.0
amylosucrase 5.0
gamma-glutamyl kinase 5.0
urease 5.0
manganese peroxidase 5.0
invertase 5.0
glutamic dehydrogenase 5.0
beta-1,3-glucanase 4.9
chitosanase 4.9
stilbene synthase 4.9
prephenate dehydrogenase 4.9
more...
Compound
phenyl 4-methylbenzenesulfonate 11.8
4-chlorobenzaldehyde thiosemicarbazone 11.8
C17H24O4 11.8
C17H24O4 11.8
Tokoronin 11.8
C17H24O4 11.8
Swertiajaponin 11.8
C17H24O4 11.8
Blue RX 11.8
C17H24O4 11.8
C17H24O4 11.8
C17H24O4 11.8
C17H24O4 11.8
4,4-dimethylchromane 11.8
C9H9NO7 11.8
Aureusidin 11.4
C15H12O2 10.8
C18H26O4 10.8
C19H17NO4 10.8
C15H12O2 10.8
C19H17NO4 10.8
C10H10ClNO2 10.8
C19H17NO4 10.8
C10H10ClNO2 10.8
C18H26O4 10.8
C19H17NO4 10.8
C10H10ClNO2 10.8
C15H12O2 10.8
Ethyl p-methoxycinnamate 10.8
C19H17NO4 10.8
C15H12O2 10.8
N-hydroxy-N'-phenylthiourea 10.8
C19H17NO4 10.8
C19H17NO4 10.8
C18H26O4 10.8
C19H17NO4 10.8
C18H26O4 10.8
gamma-Fagarine 10.8
C10H10ClNO2 10.8
C19H17NO4 10.8
C18H26O4 10.8
methyl 2-amino-3-phenylpropanoate 10.8
C19H17NO4 10.8
C16H12O4 10.8
C10H10ClNO2 10.8
C10H10ClNO2 10.8
C18H26O4 10.8
C10H10ClNO2 10.8
C19H17NO4 10.8
C10H10ClNO2 10.8
C19H17NO4 10.8
C10H10ClNO2 10.8
C10H8N2O 10.8
C19H17NO4 10.8
C10H10ClNO2 10.8
methyl 2-amino-3-phenylpropanoate 10.8
C10H10ClNO2 10.8
2,4-dihydroxy-N-(2-hydroxyethyl)benzamide 10.8
C19H14O 10.8
C19H17NO4 10.8
C19H17NO4 10.8
C19H17NO4 10.8
C19H17NO4 10.8
Haginin A 10.8
C19H17NO4 10.8
DHICA 10.7
L-dopachrome 10.6
cyclodopa 10.5
1-bromoheptane 10.4
Kojic acid 10.3
Aloesin 10.3
C8H9NO3 10.2
C8H9NO3 10.2
C8H9NO3 10.2
C8H9NO3 10.2
C18H26O4 10.2
C8H9NO3 10.2
C8H9NO3 10.2
C8H9NO3 10.2
C8H9NO3 10.2
more...