Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.10.3.1 (
tyrosinase
)
9,065
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Melanoma is the most serious type of skin cancer, with a highly metastatic phenotype. In this report, we show that
signal transducing adaptor
protein 2 (STAP-2) is involved in cell migration, proliferation, and melanogenesis as well as chemokine receptor expression and tumorigenesis in B16F10 melanoma cells. This was evident in mice injected with STAP-2 shRNA (shSTAP-2)-expressing B16F10 cells, which infiltrated organs in a completely different pattern from the original cells, showing massive colonization in the liver, kidney, and neck but not in the lung. The most important finding was that STAP-2 expression determined
tyrosinase
protein content. STAP-2 colocalized with
tyrosinase
in lysosomes and protected
tyrosinase
from protein degradation. It is noteworthy that B16F10 cells with knocked down
tyrosinase
showed similar cell characteristics as shSTAP-2 cells. These results indicated that
tyrosinase
contributed to some cellular events beyond melanogenesis. Taken together, one possibility is that STAP-2 positively regulates the protein levels of
tyrosinase
, which determines tumor invasion via controlling chemokine receptor expression.
...
PMID:STAP-2 Protein Expression in B16F10 Melanoma Cells Positively Regulates Protein Levels of Tyrosinase, Which Determines Organs to Infiltrate in the Body. 2602 34
