Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.10.3.1 (
tyrosinase
)
9,065
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Antigen processing for direct presentation on MHC class I molecules is a multistep process requiring the concerted activity of several cellular complexes. The essential steps at the beginning of this pathway, namely protein synthesis at the ribosome and degradation via the proteasome, have been known for years. Nevertheless, there is a considerable lack of factors identified to function between protein synthesis and degradation during antigen processing. Here, we analyzed the impact of the chaperone
BAG6
on MHC class I cell surface expression and presentation of virus-derived peptides. Although an essential role of
BAG6
in antigen processing has been proposed previously, we found
BAG6
to be dispensable in this pathway. Still, interaction of
BAG6
and the model antigen
tyrosinase
was enhanced during proteasome inhibition pointing towards a role of
BAG6
in antigen degradation. Redundant chaperone pathways potentially mask the contribution of
BAG6
to antigen processing and presentation.
...
PMID:Chaperone BAG6 is dispensable for MHC class I antigen processing and presentation. 2659 75
