Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.10.3.1 (
tyrosinase
)
9,065
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
As a part of an ongoing project searching for new skin-lightening agents, the inhibitory property of 6-(3-Hydroxyphenyl)-2-naphthol (
HPN
) on melanogenesis was investigated. The inhibitory action of
HPN
(IC(50)=15.2 muM) on mushroom
tyrosinase
was revealed. To further explore the action of
HPN
on melanogenesis, the inhibition of
tyrosinase
and melanin levels were measured in B16 melanoma cells (B16 cells). Results show that
HPN
inhibited
tyrosinase
activity and reduced melanin in B16 cells. Therefore, our data indicate
HPN
as a new candidate for depigmentation reagents.
...
PMID:Inhibitory effects of 6-(3-hydroxyphenyl)-2-naphthol on tyrosinase activity and melanin synthesis. 1928 Jan 61
