Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.10.3.1 (
tyrosinase
)
9,065
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Kojic acid-phenylalanine amide (KA-F-NH(2)), which showed an excellent
tyrosinase
inhibitory activity, did not inhibit melanogenesis in melanocyte due to its low cell permeability. To enhance its cell permeability by increasing lipophilicity, we prepared metal coordination compounds of KA-F-NH(2) and characterized them by FT-IR and
ICP
analysis. The metal complex of KA-F-NH(2) inhibited mushroom
tyrosinase
activity as much as KA-F-NH(2) and reduced melanin contents in melanocyte efficiently.
...
PMID:Enhanced cell permeability of kojic acid-phenylalanine amide with metal complex. 1996 89
