Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.10.3.1 (
tyrosinase
)
9,065
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Undesirable hyperpigmentation that can arise from increased melanocyte activity may be alleviated by targeting active melanocytes for apoptosis. The role of
Stathmin 1
as an important regulator of microtubule dynamics is well documented. The current study examined the potential of
Stathmin 1
-targeting strategies in eliminating active melanocytes. A vector to overexpress
Stathmin 1
and vectors to express three distinct small hairpin RNAs to knockdown
Stathmin 1
expression in normal melanocytes were produced and in cell cultures acted accordingly. Both overexpression and knockdown of
Stathmin 1
led to a marked increase in melanocyte apoptosis, as indicated by the accumulation of apoptotic cells and increased levels of cleaved caspase-3. Both up- and down-regulation of
Stathmin 1
expression inhibited the activity of differentiated melanocytes, as indicated by decreases in both melanin production and
tyrosinase
activity. Taken together, these results indicate that hyperactive melanocytes can be inhibited by altering
Stathmin 1
expression.
...
PMID:Regulation of melanocyte apoptosis by Stathmin 1 expression. 1901 87
