Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.10.3.1 (
tyrosinase
)
9,065
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The production of melanin increases skin pigmentation and reduces the risk of skin cancer. Melanin production depends on the pH of melanosomes, which are more acidic in lighter-skinned than in darker-skinned people. We showed that inhibition of
soluble adenylyl cyclase
(
sAC
) controlled pigmentation by increasing the pH of melanosomes both in cells and in vivo. Distinct from the canonical melanocortin 1 receptor (MC1R)-dependent cAMP pathway that controls pigmentation by altering gene expression, we found that inhibition of
sAC
increased pigmentation by increasing the activity of
tyrosinase
, the rate-limiting enzyme in melanin synthesis, which is more active at basic pH. We demonstrated that the effect of
sAC
activity on pH and melanin production in human melanocytes depended on the skin color of the donor. Last, we identified
sAC
inhibitors as a new class of drugs that increase melanosome pH and pigmentation in vivo, suggesting that pharmacologic inhibition of this pathway may affect skin cancer risk or pigmentation conditions.
...
PMID:Mammalian pigmentation is regulated by a distinct cAMP-dependent mechanism that controls melanosome pH. 3040 88
