Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.10.3.1 (
tyrosinase
)
9,065
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
3-Hydroxypyridine
-4-ones have potential as orally active chelators of iron(III) and therefore may find application in the treatment of thalassaemia. An undesirable feature of these molecules is that they inhibit
tyrosinase
. We have established that alkyl substitution at position 2 in the aromatic ring minimizes interaction with
tyrosinase
and does so without appreciably influencing the affinity for iron(III).
...
PMID:The inhibition of tyrosinase by pyridinones. 249 43
