Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.10.3.1 (
tyrosinase
)
9,065
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The aim of this study was to investigate the effect of emodin derived from
Polygonum multiflorum
on melanin production in B16F1 cells. In this study, emodin did not show antioxidant activity in DPPH radical and reducing power assays. However, it was found that emodin scavenged intracellular H
2
O
2
.
Emodin
increased not only
tyrosinase
activity but also melanin synthesis in vitro. Moreover, emodin enhanced melanin synthesis by increasing the expression level of
tyrosinase
(
TYR
), tyrosine related protein (TRP)-1, TRP-2, MITF and SIRT1 proteins in live cells treated with H
2
O
2
compared with H
2
O
2
treatment group in the analyses of western blot and immunofluorescence. Moreover, emodin suppressed ERK activation by SIRT1 and FOXO1. Thus, emodin promoted melanin synthesis by increasing the expression of TRP-1, TRP-2,
tyrosinase
through the activation of MITF transcription factor. These findings suggest that emodin could promote melanin production related to anti-hair graying.
...
PMID:The effect of emodin on melanogenesis through the modulation of ERK and MITF signaling pathway. 3320 68
