Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.10.3.1 (tyrosinase)
 9,065 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Metallothionein from Aspergillus niger was found to be an inhibitor, in a model system, for the enzymic activity of a commercially purified mushroom tyrosinase. The inhibitory effect of metallothionein was higher on catechin oxidation compared with that on chlorogenic acid. The degree of inhibition of enzymic colour formation by metallothionein, using catechin as substrate, was lower than that of oxygen uptake; however, a reverse pattern was observed with chlorogenic acid as substrate. The demetallization of metallothionein did not increase its inhibitory effect on polyphenol oxidase whereas pre-incubation of the enzyme and metallothionein increased this inhibitory effect.
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PMID:Inhibition of polyphenol oxidase by copper-metallothionein from Aspergillus niger. 868 93

Pakistan holds the position of top chilies producers. So Capsicum annuum L. production in Pakistan should be promoted by combating against diseases. The only solution is to cultivate resistant varieties. Presently six chili varieties were treated with Fusarium oxysporum Schlecht. and screened for the most resistant and the most susceptible varieties. Representative varieties were evaluated for their biochemical and transcriptional profiles to discover the bases of antifungal-resistance. Results concluded that the most resistant variety was "Dandicut" and the most susceptible was "Ghotki". Tannins, coumarins, flavonoids, phenolics, Riboflavins and saponins were observed in higher quantities in Dandicut as compared to Ghotki. Defense related enzymes i.e. polyphenol oxidase, phenyl ammonia lyase and peroxidase were found in elevated amounts in Dandicut than in Ghotki. Transcriptional results showed that defense related genes i.e. PR2a, acidic glucanase; Chitinase 3, acidic; Osmotin-like PR5 and Metallothionein 2b-like had higher expressional rates in Dandicut. Pearson's correlation coefficient revealed stronger direct interaction in signal transduction and salicylic acid pathway. Resistance of chili varieties is salicylic acid based. Results obtained from this study not only help to improve chili production in Pakistan but also facilitate variety development operations. Moreover, it also constructed a scale to evaluate innate resistance among varieties.
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PMID:Biochemical and Molecular Screening of Varieties of Chili Plants that are Resistant against Fusarium Wilt Infection. 2976 Sep 60