Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.1.1.41 (isocitrate dehydrogenase)
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Human Gene/Protein
H-IDH gamma 13.3
CDH14 13.3
actin-related protein T2 13.3
6-phosphogluconate dehydrogenase, decarboxylating 13.3
isocitrate dehydrogenase 13.3
isocitric dehydrogenase 13.3
NAD-IDH 12.7
NADP+-specific isocitrate dehydrogenase 12.5
cholinergic receptor, nicotinic, delta polypeptide 12.3
outer dense fiber protein 2 12.3
ME2 protein 12.3
60S ribosomal protein L23 12.3
cadherin 18, type 2 12.3
H3 histone, family 3A 12.3
H-IDH alpha 12.3
ATL-derived PMA-responsive peptide 12.3
flavoprotein-linked monooxygenase 12.3
NADH dehydrogenase flavoprotein 1 12.3
WD repeat and FYVE domain containing 3 12.3
IDH3A 11.9
IDH3B 11.9
NADP-dependent isocitrate dehydrogenase 11.8
Glucose-6-phosphate 1-dehydrogenase 11.7
D-2-hydroxyglutarate dehydrogenase 11.6
tubulin alpha-1 chain 11.5
NAD+-isocitrate dehydrogenase 11.4
IDH3G 11.3
ACTIN-2 11.3
PECI 11.3
ATP synthase gamma chain 11.3
myosin-Ic 11.3
NADP+-dependent isocitrate dehydrogenase 11.2
IDH2 11.2
actin-related protein 6 11.0
translocon-associated protein delta 11.0
aconitate hydratase 10.9
sentrin/SUMO-specific protease 10.9
IDH 10.8
alpha thalassemia/mental retardation syndrome X-linked 10.8
FIL1 10.7
UL16-binding protein 3 10.7
IDH1 10.7
NADK 10.6
alpha-ketoglutarate dehydrogenase 10.5
Nucleoside diphosphokinase 10.5
phosphoglucomutase 2 10.5
POLE1 10.5
PICD 10.5
Isocitrate dehydrogenase 10.5
IDH1 protein 10.5
heterogeneous nuclear ribonucleoprotein A3 10.3
60S acidic ribosomal protein P0 10.3
additional sex combs like 1 10.3
ADHFE1 10.3
aconitase 2 10.2
Adenosylhomocysteinase 10.2
mannose phosphate isomerase 10.1
malate dehydrogenase 10.1
fumarase 10.0
decarboxylating 10.0
Transgelin-2 10.0
OTUD6B 10.0
ATP synthase subunit alpha 9.9
fumarate hydratase 9.9
aconitase 9.9
phosphorylase, glycogen 9.9
6-phosphogluconate dehydrogenase 9.8
NDUFA4L2 9.7
uridine-cytidine kinase 2 9.7
glucose-6-phosphate 1-dehydrogenase 9.7
NADP 9.6
ribosomal protein L36 9.6
TEGT 9.6
PSA2 9.6
ropporin 9.6
Aconitase 9.6
BDB 9.5
peptidase D 9.5
NAD(+) kinase 9.5
gCap39 9.5
more...
Disease
adult brainstem glioma 12.3
Oligoastrocytoma 11.7
Oligoastrocytoma 11.7
adult pilocytic astrocytoma 10.5
ovarian mixed germ cell tumor 10.2
partial trisomy 2q 10.0
BDB 10.0
Diffuse astrocytoma 9.4
Anaplastic oligodendroglioma 9.4
Tanycytic ependymoma 9.4
Oligodendroglioma 9.3
Periosteal chondroma 9.2
Coxiella infection 9.0
Gliosarcoma 8.9
Waldenstrom's disease 8.9
ATRX 8.4
Withdrawal bleeding 8.2
adult brain tumor 7.8
Herpetosoma 7.7
Maffucci's syndrome 7.7
oligodendroglioma 7.6
RAEB-2 7.6
mixed gliomas 7.4
CPX 7.3
giant cell glioblastoma 7.3
refractory cytopenia with multilineage dysplasia 7.0
FAB M1 6.9
anaplastic astrocytoma 6.9
angioimmunoblastic T-cell lymphoma 6.7
enchondromatosis 6.7
gliosarcoma 6.6
AT/RT 6.5
AML progression 6.5
glioma 6.3
Hepatocarcinogenesis 6.3
glioblastoma 6.3
enchondroma 6.3
embryonal tumor 6.2
Glioblastoma 6.1
syndrome X 6.1
Chondrosarcoma 6.1
Chondrosarcoma 6.1
DIA 6.0
Cholangiocarcinoma 6.0
Cholangiocarcinoma 5.9
adult AML 5.8
chondromatosis 5.8
Sertoli-Leydig cell tumor 5.8
Sertoli-Leydig cell tumor 5.8
Crabs 5.8
astrocytoma 5.7
GS2 5.7
Middle cerebral artery occlusion 5.6
brain tumor 5.6
glioblastoma multiforme 5.5
Endometrium 5.5
vitamin B6 deficiency 5.5
Endometrium 5.5
MPE 5.5
drug-induced hepatitis 5.3
chondrosarcoma 5.3
RSI 5.3
HBD 5.3
hypoglycemic coma 5.3
acute myeloid leukemia 5.3
GS1 5.2
brain cancer 5.1
Chimera 5.1
KNO 5.0
chondrolysis 5.0
Copper deficiency 5.0
biliary tract cancer 4.9
glutaric aciduria 4.9
cancer relapse 4.9
caruncle 4.8
cerebral thrombosis 4.8
PMS 4.7
PDC 4.7
kwashiorkor 4.6
FDH 4.6
more...
Symptom
Central post-stroke pain 8.5
Gasping 7.4
Spots 5.5
Decreased activity 4.3
Anoxia 4.2
neurological disability 3.5
eds 3.3
decreased appetite 3.1
starvation 3.1
exhaustion 3.0
nasal discharge 2.9
hypocapnia 2.6
oliguria 2.5
twitching 2.3
blurred vision 2.3
asthenia 2.0
flushing 1.7
nausea 1.1
nausea and vomiting 1.1
numbness 1.0
shortness of breath 1.0
hyperoxia 1.0
hunger 0.9
lethargy 0.9
hypothermia 0.8
hypotonia 0.8
agitation 0.8
weakness 0.7
myalgia 0.6
functional recovery 0.6
arthralgia 0.5
seizures 0.5
acidity 0.4
hypercapnia 0.4
dystonia 0.3
syncope 0.2
dyspnea 0.1
collapse 0.1
constipation 0.0
vomiting -0.0
headache -0.1
thinning -0.1
cough -0.2
ataxia -0.6
fatigue -0.7
tremor -0.8
anesthesia -1.4
diarrhea -1.5
pain -3.1
Drug
Lysine hydrochloride 11.7
Carboxyatractyloside 8.5
Midostaurin 7.3
Fennel 7.3
citric acid 7.0
1,8-Cineole 6.9
Tween 40 6.7
NADH 6.5
Rasburicase 6.3
Florfenicol 6.1
Lead acetate 6.0
C3H8 5.5
Kaolin 5.4
Citric acid 5.3
Clofibrate 5.2
Lactase 5.2
ID2 5.2
Palmitoyl 5.1
Premarin 5.1
Copaxone 5.0
Depo-Provera 5.0
Guanidine 4.9
anti-CD33 4.9
Guanidine 4.9
Artesunate 4.9
SMP 4.7
CTT 4.6
Liraglutide 4.6
MEA 4.5
Maltose 4.5
Glycerol 4.5
Emodin 4.4
CSI 4.4
FAD 4.4
Emodin 4.2
Fructose 4.0
Kainic acid 4.0
ascorbate 3.8
Capsicum 3.8
MgSO4 3.7
Adriamycin 3.7
L-tyrosine 3.7
Acacia 3.7
Xanthium 3.6
Nitric Oxide 3.6
Bevacizumab 3.5
Adenosine triphosphate 3.5
Sodium nitroprusside 3.4
ADR 3.3
Frontal 3.3
CTC 3.3
MDS 3.2
lysine 3.2
Gel 3.1
Arsenic trioxide 3.0
CTC 3.0
ETS 3.0
Honey 3.0
Glutathione 2.9
ROS 2.8
GEO 2.7
Coral 2.7
Kenyan 2.6
Parkin 2.5
Parkin 2.5
EE2 2.4
vitamin E 2.4
EPI 2.3
DHT 2.2
DHT 2.2
CDP 2.1
NH3 2.1
pyridoxal phosphate 2.0
Angiotensin II 2.0
Alliance 1.9
ETA 1.9
Alanine 1.9
Asn 1.8
ABC 1.8
Growth hormone 1.8
more...
Enzyme
isocitrate dehydrogenase 13.3
trihydroxypterocarpan dimethylallyltransferase 13.3
EC 1.1.1.98 13.3
isocitrate dehydrogenase 13.1
PH1722 12.3
gamma-lactonase 12.3
STK3 11.9
PEP phosphatase 11.5
homoisocitrate dehydrogenase 11.1
formyltetrahydrofolate deformylase 11.0
tartrate dehydrogenase 11.0
EC 2.7.7.42 10.5
glycerophosphate phosphatase 10.5
oxoglutarate dehydrogenase 10.3
alpha-ketoglutarate dehydrogenase 10.2
malate oxidase 10.1
fumarase 10.0
aconitase 10.0
EC 1.1.1.40 10.0
isocitrate lyase 9.9
malate dehydrogenase 9.9
6-phosphogluconate dehydrogenase 9.8
6-phosphogluconate dehydrogenase 9.8
PdxA 9.6
malate synthase 9.6
EC 1.1.1.39 9.6
gluconate dehydrogenase 9.5
3-isopropylmalate dehydrogenase 9.2
beta-hydroxybutyrate dehydrogenase 9.2
sortase B 9.1
citrate synthase 9.1
glyoxylate reductase 9.0
glyoxylate reductase 9.0
EC 1.1.1.82 9.0
creatinine iminohydrolase 8.9
tripeptidase 8.9
phosphoenolpyruvate synthase 8.9
EC 1.1.1.38 8.9
glycerol 3-phosphate dehydrogenase 8.8
BCKDH 8.8
prolinase 8.8
glucose-6-phosphate dehydrogenase 8.7
penicillopepsin 8.7
shikimate dehydrogenase 8.7
glutamic dehydrogenase 8.7
succinyl-CoA synthetase 8.6
glycine dehydrogenase 8.6
glycine dehydrogenase 8.6
citrate cleavage enzyme 8.6
citrate lyase 8.5
phytanoyl-CoA hydroxylase 8.5
glycolate dehydrogenase 8.5
phosphoglucomutase 8.5
transhydrogenase 8.4
phenylpyruvate decarboxylase 8.4
2-oxoglutarate decarboxylase 8.4
succinate dehydrogenase 8.4
methylmalonate-semialdehyde dehydrogenase 8.4
glutamate dehydrogenase 8.4
glutamate dehydrogenase 8.4
pyruvate carboxylase 8.3
aryl-alcohol dehydrogenase 8.3
glutamate dehydrogenase 8.3
3-oxoacid CoA-transferase 8.3
2-hydroxyglutarate dehydrogenase 8.2
phosphoglucose isomerase 8.2
glutamate synthase 8.2
phosphomannose isomerase 8.2
L-amino-acid oxidase 8.2
octanol dehydrogenase 8.2
nicotinic acid phosphoribosyltransferase 8.1
N-acetylglucosamine kinase 8.1
glutamate synthase 8.1
octopine dehydrogenase 8.1
3-hydroxyisobutyrate dehydrogenase 8.0
acetate kinase 8.0
NADH kinase 8.0
IMP cyclohydrolase 8.0
glycine dehydrogenase 8.0
acetyl-CoA synthetase 8.0
more...
Compound
Asparagusate 12.3
2-naphthyl laurate 12.3
2-Hydroxyglutarate 12.0
isocitrate 11.4
hydroxyglutarate 10.8
C6H6O7 10.3
Sinulariolide 10.2
K-38 10.0
A 153 10.0
Butylmalonate 10.0
C4H6O6 9.9
L-Lysine monohydrochloride 9.9
1-butanesulfonic acid 9.6
Palmitoyl-L-carnitine 9.5
Meldola's Blue 9.4
PDAP 9.4
DEPA 9.4
NADP 9.3
2-keto-4-hydroxyglutarate 9.2
Canaline 9.2
DEPA 9.0
Meldola's Blue 8.9
2-oxoglutarate 8.8
Sakuranetin 8.7
2-Oxoglutarate 8.7
p-Nitroanisole 8.7
2-oxoadipate 8.6
C6H8O7 8.5
KI3 8.5
oxalacetate 8.4
6-phosphogluconate 8.3
DPN 8.0
Phenylpyruvate 7.9
Glyoxylate 7.9
IDP 7.9
Coumaphos 7.8
OH-M 7.8
Xanthurenic acid 7.8
4-oxobutanoic acid 7.7
dihydroxyacetone-phosphate 7.7
alpha-isopropylmalate 7.6
NAD 7.6
NAD 7.5
Methionine sulfoximine 7.5
NADPH 7.4
NADPH 7.4
Malate 7.4
1-naphthyl acetate 7.3
sedoheptulose 7-phosphate 7.3
Trenimon 7.2
Metaproterenol 7.2
Dydrogesterone 7.2
pentose 7.2
pentose 7.2
Potassium dichromate 7.2
pentose 7.1
pentose 7.1
Malonate 7.1
Glycolate 7.1
TET 7.0
TET 7.0
Phytanic acid 7.0
D-Glyceraldehyde 7.0
Phenylglyoxal 7.0
Azoxymethane 6.9
Bromophenol Blue 6.9
Pyruvate kinase 6.9
Azaserine 6.9
MTU 6.8
acetyl-CoA 6.8
itaconic acid 6.7
Sodium deoxycholate 6.7
erythrose-4-phosphate 6.7
Ethionine 6.6
CIT 6.6
2-keto-3-deoxygluconate 6.5
glucose-6-phosphate 6.5
Piperine 6.5
Potassium chloride 6.5
PDH 6.5
more...