Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.1.1.41 (isocitrate dehydrogenase)
 3,101 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
isocitrate dehydrogenase 2945
NADP 554
NADPH 402
malate dehydrogenase 385
NAD 367
IDH1 274
glucose-6-phosphate dehydrogenase 262
lactate dehydrogenase 242
citrate synthase 223
IDH2 199
ATP 196
IDH 190
NADH 189
Sep 185
isocitric dehydrogenase 164
Mol 158
NADP+ 158
aconitase 149
glutamate dehydrogenase 136
6-phosphogluconate dehydrogenase 124
ADP 113
NAD+ 110
aspartate aminotransferase 105
pyruvate kinase 94
alpha-ketoglutarate dehydrogenase 92
superoxide dismutase 89
NADP-dependent isocitrate dehydrogenase 87
catalase 82
pyruvate dehydrogenase 81
glutathione reductase 79
fumarase 77
hexokinase 73
alkaline phosphatase 71
TCA 70
phosphofructokinase 66
alanine aminotransferase 65
GSH 63
p53 63
ATPase 60
AMP 59
glutathione peroxidase 58
acid phosphatase 56
cytochrome c oxidase 49
phosphatase 47
pyruvate carboxylase 47
alcohol dehydrogenase 47
decarboxylating 46
histone 44
CO2 42
fumarate hydratase 41
insulin 41
Pseudomonas 40
glutamine synthetase 39
cytochrome 38
creatine kinase 37
methylguanine-DNA methyltransferase 37
reductase 36
dimeric 36
ACL 35
esterase 34
2-oxoglutarate dehydrogenase 34
glyceraldehyde-3-phosphate dehydrogenase 33
NADH dehydrogenase 33
NMR 30
oxidoreductase 30
Isocitrate dehydrogenase 29
enolase 29
phosphoenolpyruvate carboxylase 29
phosphoenolpyruvate carboxykinase 29
fatty acid synthase 28
isocitrate dehydrogenase 1 28
MRI 28
microsomal 26
phosphoglucose isomerase 26
BRAF 26
ATP synthase 25
Gen 25
glucose-6-phosphatase 24
SDS 24
cytochrome c 23
polypeptide 23
LDH 23
epidermal growth factor receptor 23
albumin 23
peroxidase 22
aconitate hydratase 22
adenylate kinase 21
ATRX 21
pyruvate dehydrogenase complex 21
SOD 20
acetylcholinesterase 20
sorbitol dehydrogenase 20
hemoglobin 20
TOF 19
methyltransferase 19
telomerase reverse transcriptase 19
triosephosphate isomerase 18
glutamate pyruvate transaminase 16
PHI 16
antioxidant enzyme 16
TERT 16
Citrate synthase 15
collagen 15
DNA methyltransferase 15
endoplasmic reticulum 15
NADP+-dependent isocitrate dehydrogenase 15
MDH 14
NAD-IDH 14
myosin heavy chain 14
lipoamide dehydrogenase 14
beta-glucuronidase 14
oxoglutarate 14
NADP+-specific isocitrate dehydrogenase 13
ROS 13
cytochrome P-450 13
aldehyde dehydrogenase 13
TPN 13
FLT3 12
lipase 12
TET2 12
mitochondrial malate dehydrogenase 12
diaphorase 12
Glucose-6-phosphate dehydrogenase 12
glycerol-3-phosphate dehydrogenase 12
NPM1 12
ICD 12
carbonic anhydrase 12
acetyl-CoA carboxylase 12
spermatozoa 11
phosphorylating 11
adenosine triphosphatase 11
lipoprotein lipase 11
vascular endothelial growth factor 11
acetyl-CoA synthetase 11
serum albumin 11
FAD 11
prohibitin 11
NADP-malic enzyme 11
epididymal 11
BDB 11
crystallin 10
amylase 10
glucokinase 10
PDH 10
caspase-3 10
5'-nucleotidase 10
H3F3A 10
G6PDH 10
ferredoxin 10
Aconitase 10
leucine aminopeptidase 9
SIRT3 9
Bcl-2 9
Bot 9
X-linked 9
thioredoxin 9
HSP70 9
transferrin 9
PTEN 9
tropomyosin 9
more...
Disease
cancer 339
tumor 302
glioma 242
glioblastoma 139
acute myeloid leukemia 131
GSH 63
brain tumor 56
tumorigenesis 49
glioblastoma multiforme 41
astrocytoma 37
leukemia 34
oligodendroglioma 33
carcinogenesis 31
cold 31
diabetes 27
carcinoma 26
SDS 24
tumor progression 22
ATRX 21
Glioblastoma 20
obesity 20
melanoma 18
ischemia 18
chondrosarcoma 17
tumor growth 17
breast cancer 16
Mycobacterium 15
myelodysplastic syndrome 15
anaplastic astrocytoma 14
depression 14
myocardial infarction 14
hepatocellular carcinoma 13
mole 12
thalassemia 12
ICD 12
pheochromocytoma 12
metastases 12
fatty liver 11
BDB 11
mole 11
tuberculosis 11
sarcoma 10
mental retardation 10
type 2 diabetes 10
mental retardation 10
Parkinson's disease 9
lymphoma 9
leukemogenesis 9
hyperglycemia 9
hematologic malignancies 9
PCC 9
primary tumor 9
ATM 9
lung cancer 9
heart failure 8
colon cancer 8
adenocarcinoma 8
Leukemia 8
malnutrition 8
prostate cancer 8
epilepsy 8
brain cancer 7
gliosarcoma 7
hepatitis 7
aggressiveness 7
colorectal cancer 7
B-cell lymphoma 6
hyperlipidemia 6
MRS 6
hyperbilirubinemia 6
renal cell carcinoma 6
iron deficiency 6
metabolic syndrome 6
Cholangiocarcinoma 6
cerebral ischemia 5
angioimmunoblastic T-cell lymphoma 5
stroke 5
syndrome X 5
acute promyelocytic leukemia 5
uterus 5
PGA 5
minimal residual disease 5
rash 5
hypothyroidism 5
malaria 5
Klebsiella 5
SEM 5
cardiomyopathy 5
Cholangiocarcinoma 5
ependymoma 5
hepatitis A 4
Alzheimer's disease 4
Gliosarcoma 4
Oligodendroglioma 4
CPX 4
T-cell lymphoma 4
dementia 4
hypoglycemia 4
fibrosarcoma 4
hypertension 4
metabolic disorder 4
Brown 4
paraganglioma 4
Hodgkin's disease 4
squamous cell carcinoma 4
encephalopathy 4
Maffucci's syndrome 4
leishmaniasis 4
anemia 4
cirrhosis 3
liver disease 3
inflammatory bowel disease 3
diabetic nephropathy 3
alcoholic fatty liver 3
residual disease 3
worms 3
cholestasis 3
endometrial cancer 3
enchondromatosis 3
chronic obstructive pulmonary disease 3
gallstones 3
osteosarcoma 3
enchondroma 3
tumor initiation 3
liver cancer 3
MCF 3
hyperthyroidism 3
thrombocytopenia 3
atherosclerosis 3
acute leukemia 3
cardiovascular disease 3
renal disease 3
Q fever 3
multiple myeloma 3
chronic myeloid leukemia 3
craniopharyngioma 3
chondromatosis 3
thyroid cancer 3
rickets 3
wasting 3
ICP 3
Chondrosarcoma 3
fits 3
developmental delay 3
Chondrosarcoma 3
epididymis 3
ADH 3
multiple endocrine neoplasia 3
infectious diseases 3
coma 3
adult AML 3
hydrocephalus 3
retinoblastoma 3
stromal tumors 3
tularemia 3
cleft palate 2
alcoholic hepatitis 2
leprosy 2
bladder cancer 2
chronic hepatitis 2
more...
Symptom
starvation 21
exhaustion 11
seizures 11
weakness 6
headache 5
nausea 5
anesthesia 4
dyspnea 3
vomiting 3
fatigue 3
hypothermia 3
collapse 3
pain 3
diarrhea 2
agitation 2
cough 2
Spots 2
acidity 2
functional recovery 2
flushing 2
nausea and vomiting 2
numbness 1
asthenia 1
constipation 1
Decreased activity 1
Central post-stroke pain 1
hyperoxia 1
Gasping 1
oliguria 1
hunger 1
tremor 1
dystonia 1
twitching 1
blurred vision 1
ataxia 1
thinning 1
shortness of breath 1
eds 1
nasal discharge 1
hypercapnia 1
Anoxia 1
lethargy 1
syncope 1
hypocapnia 1
decreased appetite 1
neurological disability 1
arthralgia 1
hypotonia 1
myalgia 1
Drug
NADH 194
citric acid 119
lysine 52
ascorbate 32
ROS 13
Gel 12
FAD 11
vitamin E 9
Adriamycin 6
Glycerol 5
Leaf 5
Glutathione 4
Asn 4
MAP 4
Cardiovasc 4
EE2 4
L-tyrosine 3
Dermatol 3
Ethanol 3
NH3 3
ABC 3
lactose 3
Capsicum 3
Fructose 3
Nitric Oxide 3
Clofibrate 2
Frontal 2
Citric acid 2
Bevacizumab 2
ADR 2
ROC 2
Depo-Provera 2
Angiotensin II 2
Rasburicase 2
Acacia 2
Kenyan 2
Tween 40 2
MgSO4 2
MDS 2
ETS 2
ID2 1
DHT 1
Kaolin 1
Parkin 1
CSI 1
MEA 1
Sodium nitroprusside 1
ETA 1
CTX 1
Guanidine 1
Xanthium 1
Lactase 1
Indomethacin 1
Nephron 1
ZnO 1
Florfenicol 1
EPI 1
Guanidine 1
Palmitoyl 1
CTC 1
CaCl2 1
CaCl2 1
CSF 1
Growth hormone 1
ICI 1
p75 1
SMP 1
Lysine hydrochloride 1
Arsenic trioxide 1
Premarin 1
Coral 1
DNase I 1
DHT 1
Parkin 1
CDP 1
Liraglutide 1
Alanine 1
Lead acetate 1
CTT 1
Emodin 1
1,8-Cineole 1
CTC 1
Carboxyatractyloside 1
C3H8 1
GEO 1
MRC 1
TiO2 1
anti-CD33 1
CaCl2 1
Artesunate 1
Emodin 1
Midostaurin 1
G-CSF 1
Kainic acid 1
niacin 1
Maltose 1
Mutagen 1
Honey 1
Copaxone 1
Adenosine triphosphate 1
Fennel 1
Growth hormone 1
Alliance 1
pyridoxal phosphate 1
Enzyme
isocitrate dehydrogenase 3101
isocitrate dehydrogenase 2960
malate dehydrogenase 432
glucose-6-phosphate dehydrogenase 323
succinate dehydrogenase 272
lactate dehydrogenase 270
citrate synthase 233
aconitase 172
alpha-ketoglutarate dehydrogenase 151
glutamate dehydrogenase 141
glutamate dehydrogenase 140
glutamate dehydrogenase 138
6-phosphogluconate dehydrogenase 127
6-phosphogluconate dehydrogenase 127
aspartate aminotransferase 120
fumarase 116
pyruvate dehydrogenase 107
superoxide dismutase 102
isocitrate lyase 95
pyruvate kinase 94
alanine aminotransferase 90
catalase 87
pyruvate dehydrogenase 82
pyruvate dehydrogenase 81
glutathione reductase 81
hexokinase 73
alkaline phosphatase 72
ATPase 71
phosphofructokinase 70
diaphorase 60
glutathione peroxidase 59
phosphoenolpyruvate carboxykinase 59
phosphoenolpyruvate carboxykinase 58
acid phosphatase 57
phosphoenolpyruvate carboxykinase 57
cytochrome oxidase 52
alcohol dehydrogenase 50
phosphoglucose isomerase 50
aldolase 49
creatine kinase 48
pyruvate carboxylase 48
phosphoglucomutase 47
complex I 46
ERK 46
glyceraldehyde-3-phosphate dehydrogenase 42
glycerol-3-phosphate dehydrogenase 42
malate synthase 39
glutamine synthetase 39
glycerol-3-phosphate dehydrogenase 39
succinic dehydrogenase 38
glyceraldehyde-3-phosphate dehydrogenase 36
glyceraldehyde-3-phosphate dehydrogenase 36
NADH dehydrogenase 35
glyceraldehyde-3-phosphate dehydrogenase 34
glyceraldehyde-3-phosphate dehydrogenase 33
phosphoenolpyruvate carboxylase 33
enolase 31
STK3 31
acetylcholinesterase 29
ATP synthase 28
diaphorase 26
glucose-6-phosphatase 25
peroxidase 25
transhydrogenase 24
beta-hydroxybutyrate dehydrogenase 22
glutamate synthase 22
adenylate kinase 22
CPR 21
EC 1.1.1.40 20
oxoglutarate dehydrogenase 20
glutamate synthase 20
phosphorylase 20
sorbitol dehydrogenase 20
SCS 19
glutamate synthase 18
aldehyde dehydrogenase 17
DNA methyltransferase 17
glutathione S-transferase 16
ACS 16
NADPH-diaphorase 16
succinyl-CoA synthetase 16
protein kinase 16
aldehyde dehydrogenase 15
trypsin 15
NQO1 14
MDH 14
MDH 14
gamma-glutamyl transpeptidase 13
lipase 13
aldehyde dehydrogenase 13
monoamine oxidase 13
acetyl-CoA carboxylase 13
aldehyde dehydrogenase 13
aldehyde dehydrogenase 13
cholinesterase 13
beta-galactosidase 13
beta-glucuronidase 12
acetate kinase 12
PGM 12
carbonic anhydrase 12
acetyl-CoA synthetase 11
lipoprotein lipase 11
fumarate reductase 11
fructose 1,6-bisphosphatase 11
3-isopropylmalate dehydrogenase 10
phosphomannose isomerase 10
glucokinase 10
citrate lyase 10
CPT 10
ACE 10
5'-nucleotidase 10
leucine aminopeptidase 9
glycerol 3-phosphate dehydrogenase 9
glutamic dehydrogenase 9
phosphoglycerate kinase 9
PDH 9
pyruvate decarboxylase 9
caspase-3 8
RNA polymerase 8
NADPH oxidase 8
3-hydroxyacyl-CoA dehydrogenase 8
xanthine oxidase 8
thioredoxin reductase 8
peroxiredoxin 8
AMP-activated protein kinase 8
PTA 8
glutaminase 7
glycolate oxidase 7
3-hydroxyacyl-CoA dehydrogenase 7
transketolase 7
invertase 7
mitogen-activated protein kinase 7
demethylase 7
shikimate dehydrogenase 6
tripeptidase 6
formate dehydrogenase 6
prolinase 6
glycine decarboxylase 6
condensing enzyme 6
GABA transaminase 6
acyl-CoA dehydrogenase 6
PARP 6
NADPH oxidase 6
formate dehydrogenase 6
arginase 6
gluconate dehydrogenase 6
formate dehydrogenase 6
uricase 6
PDK1 6
ascorbate peroxidase 6
alpha-glucosidase 6
carboxylesterase 6
nitrate reductase 5
lactic acid dehydrogenase 5
nitrate reductase 5
nitrate reductase 5
nitrate reductase 5
hexosaminidase 5
homoisocitrate dehydrogenase 5
alanine dehydrogenase 5
more...
Compound
NADP 714
NAD 476
isocitrate 446
NADPH 410
NADPH 402
NAD 367
glucose 364
2-oxoglutarate 331
DNA 268
phosphate 262
oxygen 247
Dec 203
ATP 196
NADH 194
acetate 175
glutamate 175
hydroxyglutarate 167
ADP 116
ADP 113
ADP 113
nitrogen 110
nicotinamide 106
Clin 93
pentose 89
pentose 89
pentose 89
pentose 89
calcium 83
glutamine 75
TCA 72
glycerol 71
water 69
GSH 68
GSH 68
alanine 65
sodium 65
lysine 61
AMP 60
CO2 59
acetyl-CoA 57
manganese 54
hydrogen 52
ammonium 52
arginine 51
alcohol dehydrogenase 47
CoA 47
iron 46
Mg2+ 46
sulfate 43
ethanol 35
tyrosine 35
urea 34
salt 34
glucose-6-phosphate 32
zinc 30
His 30
ammonia 30
cysteine 30
hexose 29
hexose 29
hexose 29
serine 29
hexose 29
pyridine 27
succinic acid 27
SDS 26
CIT 26
oxalacetate 24
leucine 24
copper 23
nitric oxide 23
Asp 22
methionine 22
glutamic acid 20
Glutamate 20
H2O2 20
nitrate 19
galactose 19
TOF 19
proline 17
cadmium 17
phosphorus 17
acetic acid 17
potassium 16
cAMP 16
6-phosphogluconate 16
cyanide 16
threonine 16
Phe 15
ornithine 15
ornithine 15
ornithine 15
ornithine 15
NH2 15
Gly 15
ornithine 15
aluminum 14
EDTA 14
EDTA 14
malic acid 14
Lactate 14
creatinine 13
DPN 12
adenylate 12
GSSG 12
FAD 11
DEAE 11
pyrene 10
acrylamide 10
Ile 10
GABA 9
bromide 9
TEM 9
tryptophan 9
asparagine 9
tryptophan 9
PEG 9
GABA 9
PDH 9
Malate 9
tryptophan 9
tryptophan 9
CCl4 9
noradrenaline 8
aldehyde 8
TET 8
succinic acid 8
TET 8
carbonate 8
alloxan 8
PEP 8
succinic acid 8
succinic acid 8
succinic acid 8
Flux 8
2-Hydroxyglutarate 8
aspartic acid 8
methanol 7
CAT 7
L-carnitine 7
CAT 7
IDP 7
xylose 7
ACS 7
CAT 7
ACS 7
valine 7
2-Oxoglutarate 6
acetone 6
dicarboxylic acid 6
Sucrose 6
Triton X-100 6
selenium 6
oxalate 6
GPT 6
GTP 6
superoxide radical 6
uridine 6
Cytochrome c 6
Pac 6
more...