Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.1.1.37 (malate dehydrogenase)
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Human Gene/Protein
TYSND1 12.8
leucine-rich PPR motif-containing protein 12.8
malate dehydrogenase 12.8
MDH 12.8
Cytosolic malate dehydrogenase 11.9
mitochondrial malate dehydrogenase 11.9
flavoprotein-linked monooxygenase 11.8
G protein beta subunit-like protein 11.8
Lon protease-like protein 11.8
isochorismatase domain containing 1 11.8
HSPA9 protein 11.8
Malic dehydrogenase 11.7
cytosolic malate dehydrogenase 11.5
Malate dehydrogenase 11.4
MDH2 11.4
hydroxysteroid dehydrogenase like 2 11.2
ACON 11.2
MDH1 11.0
ACTIN-2 10.8
T-complex protein 1 subunit beta 10.8
pyruvate carboxylase, mitochondrial 10.8
MTATP8 10.8
archain 10.8
mannose phosphate isomerase 10.5
RBP50 10.4
fumarase 10.4
NADP-dependent malic enzyme 10.3
isocitric dehydrogenase 10.2
TINP1 10.2
Myokinase 10.2
NADP-malic enzyme 10.1
decarboxylating 10.1
alpha-ketoglutarate dehydrogenase 10.0
6PGD 10.0
elongation factor 1-gamma 10.0
LDHL 10.0
transposase-like protein 10.0
phosphoglucomutase 2 10.0
isocitrate dehydrogenase 9.9
aconitate hydratase 9.9
Malic enzyme 9.9
succinyl coenzyme A synthetase 9.8
hClp1 9.8
MTCO3 9.8
PGM 9.7
L-alpha-glycerophosphate dehydrogenase 9.7
G3PD 9.7
fructose-bisphosphatase 9.7
nidogen 2 9.6
NADP+-dependent malic enzyme 9.6
RPL39 9.6
NADP-dependent isocitrate dehydrogenase 9.5
glycogen phosphorylase B 9.4
ribosomal protein L35 9.4
Formiminotransferase-cyclodeaminase 9.4
6-phosphogluconate dehydrogenase 9.4
phosphoenolpyruvate carboxylase 9.4
NAD-IDH 9.4
PEPD 9.4
G6PDH 9.4
NADP-ME 9.3
14-3-3 epsilon protein 9.3
ATP synthase subunit alpha 9.3
AK2B 9.3
AEP1 9.3
Telethonin 9.3
MTND5 9.3
ENPP3 9.3
MTCYB 9.3
NAD-malic enzyme 9.3
hydroxypyruvate reductase 9.2
NAD-dependent glyceraldehyde-3-phosphate dehydrogenase 9.2
PGDH 9.2
NADPH2 9.2
MTND3 9.2
SRPR 9.2
3-hydroxybutyrate dehydrogenase 9.2
citrate synthase 9.2
fructose-1,6-bisphosphatase 9.1
E2k 9.1
more...
Disease
Serum carnosinase deficiency 10.0
LDHL 9.3
SPG13 9.2
Equine recurrent uveitis 8.9
DIA 8.3
Aspergillus flavus infection 8.1
Klebs 8.0
porcine stress syndrome 7.9
ASAT 7.9
Zoonotic cutaneous leishmaniasis 7.6
LAP 7.6
Richner-Hanhart syndrome 7.6
FDH 7.5
X-linked hypogammaglobulinemia 7.4
Brill 7.4
KAR 7.4
AAT2 7.4
Rhodesian sleeping sickness 7.3
Hyperamylasemia 7.2
Herpetosoma 7.1
SMA II 7.1
ADH 7.0
cardiac aneurysm 7.0
HHG 6.7
Bladder outlet obstruction 6.6
SAMS 6.6
Batten 6.6
PNP deficiency 6.5
NHD 6.5
MNS 6.4
alcoholic cardiomyopathy 6.4
Acute decompensated heart failure 6.2
hereditary fructose intolerance 6.1
Lederer 6.1
Benson 6.1
MDK 6.0
AAT1 6.0
diphyllobothriasis 6.0
Buchanan 6.0
Dressler 5.9
ACP 5.8
viral carcinogenesis 5.8
HBD 5.7
primary amebic meningoencephalitis 5.7
PFD 5.5
PMS 5.5
ALD 5.5
anthracosis 5.4
hereditary ataxia 5.4
L. infantum 5.3
trisomy 9 5.2
American cutaneous leishmaniasis 5.2
Globus 5.1
GS2 5.1
chlorosis 5.1
nagana 5.1
tyrosinemia 5.1
Dicrocoelium dendriticum 5.0
VPI 5.0
PER 4.9
AD1 4.9
Crohn's colitis 4.9
olivopontocerebellar atrophy 4.8
SM1 4.8
Enzyme inhibition 4.8
AHL 4.7
placentitis 4.7
APOA1 4.7
hypoglycemic coma 4.7
Rust 4.7
GS1 4.6
testicular atrophy 4.5
AIP 4.5
Chimera 4.5
serous otitis media 4.5
Brucella abortus 4.5
AIP 4.4
sprue 4.4
Franklin 4.3
Chronic infection 4.2
more...
Symptom
Deafferentation 5.4
Decreased activity 5.3
ACHE 4.9
Tenderness 4.2
eds 3.7
CSR 3.3
starvation 3.1
DNA marker 2.9
acidity 2.9
twitching 2.8
exhaustion 2.2
collapse 1.5
pallor 1.5
fatigue 0.7
stigma 0.6
splenomegaly 0.5
hyperoxia 0.4
hunger 0.3
lethargy 0.3
hepatomegaly 0.3
hypotonia 0.2
agitation 0.2
flushing 0.1
tinnitus 0.1
anorexia 0.0
vertigo -0.0
spasm -0.1
dystonia -0.3
hypothermia -0.3
syncope -0.4
dizziness -0.5
seizures -0.5
discomfort -0.7
discomfort -0.8
functional recovery -1.0
ataxia -1.2
chest pain -1.3
anesthesia -1.4
tremor -1.4
angina -1.6
nausea -1.8
vomiting -2.2
weakness -2.5
pain -2.7
diarrhea -3.1
Drug
Sulfopyruvate 10.4
Parbendazole 9.4
Arava 7.8
Fennel 7.7
Naftidrofuryl 7.5
NADH 7.3
Activase 7.2
AKM 7.0
Atabrine 6.9
C4H10 6.6
Sterile water 6.6
TMX 6.5
Propentofylline 6.4
1,8-Cineole 6.3
Malonaldehyde 6.1
citric acid 6.1
Mazindol 5.9
Cibacron Blue 5.9
Pepstatin 5.8
RBT 5.6
Human Serum Albumin 5.5
Soybean oil 5.5
3-Methyladenine 5.4
Pentostam 5.4
Guar gum 5.2
Lipidex 5.2
PE2 4.9
Maltose 4.9
Cytidine 4.9
OTC 4.8
Rasburicase 4.8
Photofrin II 4.7
FAD 4.7
Cellulose acetate 4.7
CER 4.7
Clofibrate 4.6
Sodium valproate 4.4
Ergosterol 4.4
Guanidine 4.4
Guanidine 4.4
Piracetam 4.3
OTC 4.3
Flunitrazepam 4.3
Fructose 4.2
Alanine 4.1
Adenosine triphosphate 3.9
Capsicum 3.9
Emodin 3.9
CSI 3.9
PFT 3.8
pyridoxal phosphate 3.8
Citric acid 3.8
Cellulase 3.8
ACT 3.7
Emodin 3.6
Cremophor EL 3.5
NBT 3.4
ascorbate 3.4
Adenosine deaminase 3.3
Carotenoid 3.3
L-tyrosine 3.1
Triclosan 3.1
TAC 3.1
Diurnal 3.0
PTC 3.0
Photofrin 2.9
Gel 2.9
Isoniazid 2.8
CAM 2.8
Sodium nitroprusside 2.8
Diphenhydramine 2.7
Galactose 2.7
Ketoconazole 2.7
CTC 2.7
FLP 2.7
DHT 2.7
Hypaque 2.6
DHT 2.6
Kenyan 2.6
Adriamycin 2.6
more...
Enzyme
glycerin-3-phosphate dehydrogenase 12.8
malate-lactate transhydrogenase 12.8
glucose phosphomutase 12.8
EC 1.1.1.98 12.8
malate dehydrogenase 12.8
MDH 12.7
MDH 12.6
EC 1.1.99.16 12.6
EC 1.1.1.82 12.4
EC 6.2.1.26 11.8
allyl-alcohol dehydrogenase 11.8
EC 1.1.1.15 11.8
EC 1.1.1.38 11.8
pyrroline-2-carboxylate reductase 11.4
malate oxidase 11.3
quercetin 3-O-methyltransferase 11.2
EC 1.3.1.37 11.2
EC 1.1.1.39 11.1
EC 1.1.1.40 11.0
oxaloacetate tautomerase 11.0
strombine dehydrogenase 10.8
malease 10.8
dulcitol dehydrogenase 10.8
octanol dehydrogenase 10.6
D-malate dehydrogenase 10.6
coniferin beta-glucosidase 10.4
EC 5.3.1.16 10.4
EC 1.1.1.56 10.2
PPDK 10.1
fumarase 10.1
NAD+ oxidoreductase 10.0
glycerophosphate phosphatase 10.0
ribonuclease alpha 10.0
tartronate semialdehyde reductase 10.0
PEP phosphatase 10.0
isocitrate dehydrogenase 9.9
isocitrate dehydrogenase 9.7
hydroxypyruvate reductase 9.6
L-fuculose 1-phosphate aldolase 9.6
L-fuculokinase 9.6
hydroxypyruvate reductase 9.6
alpha-ketoglutarate dehydrogenase 9.5
2-oxoisovalerate dehydrogenase 9.4
OSBS 9.4
citrate cleavage enzyme 9.4
6-phosphogluconate dehydrogenase 9.4
6-phosphogluconate dehydrogenase 9.4
phosphoenolpyruvate carboxylase 9.4
SBPase 9.3
citryl-CoA lyase 9.3
octopine dehydrogenase 9.3
2-hydroxyglutarate dehydrogenase 9.3
shikimate dehydrogenase 9.2
BCKDH 9.2
phosphoglucomutase 9.2
citrate synthase 9.2
glutamic dehydrogenase 9.1
gluconate dehydrogenase 9.1
beta-hydroxybutyrate dehydrogenase 9.1
citrate lyase 9.1
PGM 9.1
oxaloacetate decarboxylase 9.1
UDP-N-acetylglucosamine 4-epimerase 9.1
isocitrate lyase 9.0
malate synthase 9.0
oxoglutarate dehydrogenase 9.0
phosphoglucose isomerase 9.0
fructose 1,6-bisphosphatase 8.9
glycolate dehydrogenase 8.9
tartrate dehydrogenase 8.9
D-glucitol-6-phosphate dehydrogenase 8.9
aconitase 8.8
PDH 8.8
fumarate reductase 8.8
4-hydroxybutyrate dehydrogenase 8.8
opine dehydrogenase 8.8
succinyl-CoA synthetase 8.7
phosphoenolpyruvate carboxykinase 8.7
succinic dehydrogenase 8.6
mannitol dehydrogenase 8.6
more...
Compound
Papyriferic acid 12.8
Papyriferic acid 11.8
Agaricic acid 11.8
1,3-difluoroacetone 11.8
(S)-Mandelate 11.2
1,3-difluoro-2-propanol 11.2
Chlorothricin 10.8
Potassium sulfate 10.4
Potassium sulfate 10.4
2-hydroxyethyl carbamate 10.4
arginine succinate 10.2
Succinic acid monomethyl ester 10.2
Piromidic acid 10.2
2-Hydroxyglutarate 10.0
C4H2O4 10.0
oxalacetate 9.9
d-lactoylglutathione 9.6
3-sulfopyruvate 9.6
Naphthol AS-D 9.6
Fluoropyruvate 9.6
Malate 9.5
Butylmalonate 9.4
K-38 9.4
C4H6O6 9.3
GAH 9.2
1-butanesulfonic acid 9.1
4-Methylcatechol 9.0
Ribose 5-phosphate 9.0
Cambendazole 9.0
dimethyl succinate 8.9
3-iodopyridine 8.9
Naphthol AS-D 8.8
Oxamate 8.7
Maleylacetate 8.6
Prunetin 8.6
NADP 8.5
Thiamine triphosphate 8.4
1-Anilinonaphthalene 8.4
Thiamine triphosphate 8.4
Methylcitric acid 8.3
SQ 20009 8.3
PDH 8.2
3-HP 8.2
malic acid 8.2
Mono-n-butyl phthalate 8.1
isocitrate 8.1
Oxythiamine 8.1
Methyl linoleate 8.0
propionyl-coenzyme A 7.9
Streptolydigin 7.8
Pinitol 7.8
Arachidic acid 7.7
malic acid 7.6
AAT 7.5
Brusatol 7.5
malic acid 7.5
malic acid 7.5
Melarsoprol 7.4
Phenylpyruvate 7.4
Gramicidin S 7.4
Fumarate 7.4
6-phosphogluconate 7.4
Withanolide 7.3
Hycanthone 7.3
NADH 7.3
Hydroxypyruvate 7.2
L-methylmalonyl-CoA 7.2
Pantethine 7.2
MAK 7.2
2-oxoglutarate 7.2
2-Oxoglutarate 7.2
NAD 7.2
Galacturonic acid 7.1
NAD 7.1
L-Lactate 7.1
Nandrolone decanoate 7.1
DCVC 7.1
Ribulose 7.0
Pinitol 7.0
2,4-DB 7.0
more...