Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:1.1.1.37 (
malate dehydrogenase
)
4,591
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Airborne fine particles, generating from human activities, have drawn increasing attention due to their potential lung health hazards. The currently available toxicological data on fine particles is still not sufficient to explain their cause-and-effect. Based on well reported critical role of ATP on maintaining lung structure and function, the alterations of ATP production and energy metabolism in lungs of rats exposed to different dosages of seasonal PM
2.5
were investigated. Haze dosage PM
2.5
exposure was demonstrated to reduce the ATP production. Activity of critical enzymes in TCA cycle, such as
malate dehydrogenase
(
MDH
) and citrate synthase (CS), and expression of mitochondrial respiration chain genes were attenuated in groups exposed to haze dosage PM
2.5
. In contrast, there was prominent augment of glycolytic markers at haze dosage PM
2.5
, including metabolite contents (pyruvate and lactic acid), enzyme activities (hexokinase (HK) and pyruvate kinase (PKM)), along with mRNA levels of PKM and LDH. Consequently, sub-chronic exposure to seasonal haze PM
2.5
caused reduction in ATP generation and metabolic rewiring from TCA cycle to glycolysis. Our findings can help better understand the toxicological mechanism of
lung disease
caused by particulate air pollution.
...
PMID:Exposure to ambient fine particles causes abnormal energy metabolism and ATP decrease in lung tissues. 3080 11
