Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:1.1.1.3 (HSD)
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Human Gene/Protein
SDR9C4 13.2
HSD11B1L protein 13.2
HSD 13.1
HSD11B1L 12.2
phosphoinositide-3-kinase, catalytic, beta polypeptide 12.2
HSD8 12.0
HSD-1 11.8
17-beta-HSD 11.8
17 beta-hydroxysteroid dehydrogenase 11.7
PHA I 11.6
FAM89A 11.6
chlordecone reductase 11.4
HSD3 11.4
20 alpha-hydroxysteroid dehydrogenase 11.4
17beta-hydroxysteroid dehydrogenase type 3 11.4
HSD13 11.2
HSD5 11.0
HSD1 10.9
3 beta-HSD type II 10.8
hydroxysteroid dehydrogenase-like protein 10.8
RB3 protein 10.8
CKLFSF2 10.8
StAR 10.8
3alpha-HSD 10.7
3 beta-HSD 10.6
3-beta-hydroxysteroid dehydrogenase 10.6
RODH 10.6
3 beta-hydroxysteroid dehydrogenase 10.5
HSD4 10.5
MT1R 10.5
P450C17 10.4
HSD2 10.4
RDHL 10.4
P450scc 10.3
alpha-kinase 1 10.2
HSD17B6 10.2
Retinol dehydrogenase 10.2
dihydrodipicolinate synthase 10.1
P450c17 10.1
20alpha-hydroxysteroid dehydrogenase 10.0
more...
Disease
Benign meningioma 12.6
Sex cord-stromal tumor 11.6
Alcohol-induced pseudo-Cushing's syndrome 11.6
PHA I 11.6
Late onset congenital adrenal hyperplasia 10.6
Chronic inflammatory disease 9.8
Male pseudohermaphroditism 9.8
PHA1 9.2
WNS 9.2
PHA2 9.2
3 beta-HSD deficiency 9.1
MGA3 9.0
Androgen excess 8.4
ADSA 8.4
adrenal hypertension 8.3
testicular dysfunction 8.3
NSD 7.8
Leydig cell hyperplasia 7.6
mumps orchitis 7.6
Testes 7.5
Leydig cell hypoplasia 7.4
Gordon's syndrome 7.4
cystic ovary 7.4
Allergic fungal sinusitis 7.3
adrenal neoplasm 7.2
Hypoxic-ischemic brain injury 7.2
IPS 7.2
Liddle's syndrome 7.1
hypokalemic alkalosis 6.8
Male hypogonadism 6.7
11 beta-hydroxylase deficiency 6.6
Pseudopregnancy 6.6
congenital adrenal hyperplasia 6.5
Testis 6.5
Testis 6.5
Steroids 6.4
Ondine's curse 6.4
Ondine's curse 6.4
BCD 6.4
ovarian dysfunction 6.4
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Symptom
Balding 8.1
Tissue sensitivity 8.0
masculinization 6.5
Cushingoid 6.4
Cushingoid 6.4
voice change 5.9
male subfertility 5.1
Decreased activity 5.1
loss of balance 4.3
CSR 3.7
dry skin 3.2
hypersomnia 3.1
polydipsia 3.1
muscle stiffness 2.9
polyuria 2.6
physical appearance 2.6
sciatica 2.6
rhinorrhea 2.0
acute stress 2.0
pallor 1.9
knee pain 1.7
snoring 1.7
HSA 1.6
flushing 1.5
dysarthria 1.3
acidity 1.3
agitation 1.2
dystonia 1.1
hepatosplenomegaly 1.1
fatigue 1.0
ENT 0.8
hunger 0.7
lethargy 0.7
hypothermia 0.7
hepatomegaly 0.7
hypotonia 0.6
starvation 0.6
overweight 0.5
exhaustion 0.4
distraction -0.0
more...
Drug
Aicar 12.2
Saccharin sodium 11.2
Trilostane 10.4
Gadofosveset trisodium 10.2
Bear bile 9.7
Factrel 9.7
Adosterol 9.6
Carbenoxolone 9.5
Almora 9.0
Ganaxolone 8.8
Phosphagen 8.2
Gestrinone 8.2
Vitamin-E 7.9
CEG 7.7
Benzofuran 7.6
Pregnenolone 7.6
CEG 7.5
Lead acetate 7.4
Alarin 7.3
Cortrosyn 7.2
Fosmidomycin 7.1
Dihydrotestosterone 7.1
DHT 7.0
Calcium silicate 7.0
Cortrosyn 7.0
DHT 6.9
Ciprofibrate 6.9
Ethibond 6.5
Ketorolac tromethamine 6.4
Dutasteride 6.3
Digitalis 6.2
Tenoxicam 6.2
FSH-beta 6.2
FSH-beta 6.1
Furan 6.1
Arimidex 6.0
Sulphasalazine 5.9
FSH-beta 5.9
SrCl2 5.8
SrCl2 5.6
more...
Enzyme
HSD 13.2
EC 1.1.1.201 13.2
3-KSR 12.6
3alpha(17beta)-HSD 12.2
12alpha-hydroxysteroid dehydrogenase 11.8
aspartokinase 11.6
3beta-HSDH 11.4
homoserine kinase 11.3
11beta-hydroxysteroid dehydrogenase 11.3
17beta-HSD 11.3
3beta-hydroxysteroid dehydrogenase 11.3
threonine synthase 11.2
7alpha-hydroxysteroid dehydrogenase 11.1
17beta-HSD 10.9
20alpha-hydroxysteroid dehydrogenase 10.6
dihydrodipicolinate synthase 10.3
prostaglandin F synthase 10.1
hydroxyprostaglandin dehydrogenase 10.0
cytochrome P-450scc 9.8
diaminopimelate dehydrogenase 9.7
aspartate semialdehyde dehydrogenase 9.7
3alpha-hydroxysteroid dehydrogenase 9.3
17-ketoreductase 9.2
dihydrodipicolinate reductase 9.2
homoserine transacetylase 9.1
carbonyl reductase 9.0
5beta-reductase 9.0
saccharopine dehydrogenase 8.9
EC 5.3.3.2 8.8
tropinone reductase 8.8
threonine deaminase 8.7
ecdysone 20-monooxygenase 8.7
dihydrodiol dehydrogenase 8.7
3-hydroxyisobutyryl-CoA hydrolase 8.6
NAD+ synthetase 8.6
25-hydroxyvitamin D3 1alpha-hydroxylase 8.5
20beta-hydroxysteroid dehydrogenase 8.5
steroid sulfotransferase 8.1
SsuD 8.0
diaminopimelate decarboxylase 8.0
more...
Compound
3-(4-methoxyphenyl)-2-thioxo-1,3-thiazolidin-4-one 13.2
1-(4-methoxyphenyl)-2-methyl-1-propanone 12.2
alpha-THF 11.5
undecanamide 10.9
7alpha-Methyl-19-nortestosterone 10.8
Lactucin 10.6
6-Hydroxyflavone 10.4
alpha-cortol 10.4
7-Ketolithocholic acid 10.4
11-Dehydrocorticosterone 10.2
Pyridoxal hydrochloride 10.2
pregn-5-ene-3,20-dione 10.2
Remin 10.2
GDMA 10.0
2-methylcyclopentanone 9.6
Pyridoxine hydrochloride 9.5
C3H7NO2 9.4
Miroestrol 9.3
7H-benzo[c]fluorene 9.0
HPTE 8.8
22R-hydroxycholesterol 8.7
Glycyrrhetinic acid 8.7
androstan-17-one 8.7
dimethyl isophthalate 8.7
androstan-17-one 8.7
diphenyl phthalate 8.7
Promegestone 8.7
diphenyl phthalate 8.6
androstane-3,17-dione 8.6
Glycyrrhetinic acid 8.6
Dicyclohexyl 8.6
Androstenedione 8.4
4-tert-Octylphenol 8.3
17alpha-hydroxypregnenolone 8.3
Quinalphos 8.2
Hydroxyflutamide 8.2
4-tert-Octylphenol 8.2
Coumestrol 8.1
2-propyn-1-ol 8.1
2-methylcyclohexanone 8.1
more...